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Self-coacervation of ampholyte polymer chains as an efficient encapsulation strategy.

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Title: Self-coacervation of ampholyte polymer chains as an efficient encapsulation strategy.
Authors: Perro, Adeline1 (AUTHOR) adeline.perro@enscbp.fr, Giraud, Lauriane1 (AUTHOR), Coudon, Noémie1 (AUTHOR), Shanmugathasan, Sharvina1 (AUTHOR), Lapeyre, Véronique1 (AUTHOR), Goudeau, Bertrand1 (AUTHOR), Douliez, Jean-Paul1 (AUTHOR), Ravaine, Valérie1 (AUTHOR)
Source: Journal of Colloid & Interface Science. Jul2019, Vol. 548, p275-283. 9p.
Subjects: Gelation, Calcium ions, Polymers, Phase separation, Coacervation, Isoelectric point
Abstract: Coacervation is a phase separation process involving two aqueous phases, one solute-phase and one solute-poor phase. It is frequently observed among oppositely-charged polyelectrolyte systems. In this study, we focus on self-coacervation involving a single polymer chain and investigate its potential for encapsulation applications. Negatively charged polyacrylic acid polymer chains were partially cationized using diamine and carbodiimide chemistry affording ampholytes, named PAA-DA, with tunable charge ratio. When dispersed in water, at pH 7, PAA-DA was soluble but a phase separation occurs when decreasing pH close to the isoelectric point. Coacervation is found only for a given amine-to-acid ratio otherwise precipitation is observed. Increasing the pH above 4 yielded progressive destruction of the coacervates droplets via the formation of vacuoles within droplets and subsequent full homogeneous redispersion of PAA-DA in water. However, addition of calcium allowed increasing the coacervate droplet stability upon increasing the pH to 7 as the divalent ion induced gelation within droplets. Moreover, the coacervate droplets present the ability to spontaneously sequestrate a broad panel of entities, from small molecules to macromolecules or colloids, with different charges, size and hydrophobicity. Thanks to the reversible character of the coacervates, triggered-release could be easily achieved, either by varying the pH or by removing calcium ions in the case of calcium-stabilized coacervates. Self-coacervation presents the advantage of pathway-independent preparation, offering a real output interest in pharmacy, water treatment, food science or diagnostics. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 136154376
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Self-coacervation of ampholyte polymer chains as an efficient encapsulation strategy.
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  Data: <searchLink fieldCode="AR" term="%22Perro%2C+Adeline%22">Perro, Adeline</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> adeline.perro@enscbp.fr</i><br /><searchLink fieldCode="AR" term="%22Giraud%2C+Lauriane%22">Giraud, Lauriane</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coudon%2C+Noémie%22">Coudon, Noémie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shanmugathasan%2C+Sharvina%22">Shanmugathasan, Sharvina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lapeyre%2C+Véronique%22">Lapeyre, Véronique</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goudeau%2C+Bertrand%22">Goudeau, Bertrand</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Douliez%2C+Jean-Paul%22">Douliez, Jean-Paul</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ravaine%2C+Valérie%22">Ravaine, Valérie</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Colloid+%26+Interface+Science%22">Journal of Colloid & Interface Science</searchLink>. Jul2019, Vol. 548, p275-283. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Gelation%22">Gelation</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+ions%22">Calcium ions</searchLink><br /><searchLink fieldCode="DE" term="%22Polymers%22">Polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Phase+separation%22">Phase separation</searchLink><br /><searchLink fieldCode="DE" term="%22Coacervation%22">Coacervation</searchLink><br /><searchLink fieldCode="DE" term="%22Isoelectric+point%22">Isoelectric point</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Coacervation is a phase separation process involving two aqueous phases, one solute-phase and one solute-poor phase. It is frequently observed among oppositely-charged polyelectrolyte systems. In this study, we focus on self-coacervation involving a single polymer chain and investigate its potential for encapsulation applications. Negatively charged polyacrylic acid polymer chains were partially cationized using diamine and carbodiimide chemistry affording ampholytes, named PAA-DA, with tunable charge ratio. When dispersed in water, at pH 7, PAA-DA was soluble but a phase separation occurs when decreasing pH close to the isoelectric point. Coacervation is found only for a given amine-to-acid ratio otherwise precipitation is observed. Increasing the pH above 4 yielded progressive destruction of the coacervates droplets via the formation of vacuoles within droplets and subsequent full homogeneous redispersion of PAA-DA in water. However, addition of calcium allowed increasing the coacervate droplet stability upon increasing the pH to 7 as the divalent ion induced gelation within droplets. Moreover, the coacervate droplets present the ability to spontaneously sequestrate a broad panel of entities, from small molecules to macromolecules or colloids, with different charges, size and hydrophobicity. Thanks to the reversible character of the coacervates, triggered-release could be easily achieved, either by varying the pH or by removing calcium ions in the case of calcium-stabilized coacervates. Self-coacervation presents the advantage of pathway-independent preparation, offering a real output interest in pharmacy, water treatment, food science or diagnostics. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jcis.2019.04.033
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 275
    Subjects:
      – SubjectFull: Gelation
        Type: general
      – SubjectFull: Calcium ions
        Type: general
      – SubjectFull: Polymers
        Type: general
      – SubjectFull: Phase separation
        Type: general
      – SubjectFull: Coacervation
        Type: general
      – SubjectFull: Isoelectric point
        Type: general
    Titles:
      – TitleFull: Self-coacervation of ampholyte polymer chains as an efficient encapsulation strategy.
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            NameFull: Perro, Adeline
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            NameFull: Giraud, Lauriane
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            NameFull: Coudon, Noémie
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            NameFull: Shanmugathasan, Sharvina
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            NameFull: Lapeyre, Véronique
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            NameFull: Goudeau, Bertrand
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            – D: 15
              M: 07
              Text: Jul2019
              Type: published
              Y: 2019
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              Value: 548
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            – TitleFull: Journal of Colloid & Interface Science
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