FR901483: Synthetic Efficiency Remains a Challenge.
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| Title: | FR901483: Synthetic Efficiency Remains a Challenge. |
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| Authors: | Ruan, Zhuwei1,2 (AUTHOR) rhong@sioc.ac.cn, Li, Cheng3 (AUTHOR), Shen, Defeng1,2 (AUTHOR), Huang, Sha-Hua2,4 (AUTHOR) shahua@sit.edu.cn, Hong, Ran2 (AUTHOR) |
| Source: | Synthesis. 2019, Vol. 51 Issue 11, p2237-2251. 15p. |
| Subjects: | Drug development, Alkaloids, Antimetabolites, Skeleton |
| Abstract: | FR901483 is a unique alkaloid bearing an aza-tricyclic structure, a phosphate group, and a congested tertiary nitrogen center. This alkaloid was reported to be a potent immunosuppressant with antimetabolite ability. The unprecedented architecture has captured imagination of synthetic chemists since its isolation in 1996. To date, ten total or formal syntheses and several synthetic approaches to access the tricyclic core skeleton have been reported. In this review, we highlight the novel synthetic methods and strategies and discuss the synthetic challenge for meeting the criteria of drug development. 1 Introduction 2 Bioinspired Total Synthesis of FR901483 3 Non-bioinspired Approaches toward FR901483 4 Various Tactics for Accessing the Core Skeleton 5 Challenges for Efficiency [ABSTRACT FROM AUTHOR] |
| Copyright of Synthesis is the property of Georg Thieme Verlag Stuttgart and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 136507872 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: FR901483: Synthetic Efficiency Remains a Challenge. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ruan%2C+Zhuwei%22">Ruan, Zhuwei</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> rhong@sioc.ac.cn</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Cheng%22">Li, Cheng</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Defeng%22">Shen, Defeng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Sha-Hua%22">Huang, Sha-Hua</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<i> shahua@sit.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Hong%2C+Ran%22">Hong, Ran</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Synthesis%22">Synthesis</searchLink>. 2019, Vol. 51 Issue 11, p2237-2251. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Drug+development%22">Drug development</searchLink><br /><searchLink fieldCode="DE" term="%22Alkaloids%22">Alkaloids</searchLink><br /><searchLink fieldCode="DE" term="%22Antimetabolites%22">Antimetabolites</searchLink><br /><searchLink fieldCode="DE" term="%22Skeleton%22">Skeleton</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: FR901483 is a unique alkaloid bearing an aza-tricyclic structure, a phosphate group, and a congested tertiary nitrogen center. This alkaloid was reported to be a potent immunosuppressant with antimetabolite ability. The unprecedented architecture has captured imagination of synthetic chemists since its isolation in 1996. To date, ten total or formal syntheses and several synthetic approaches to access the tricyclic core skeleton have been reported. In this review, we highlight the novel synthetic methods and strategies and discuss the synthetic challenge for meeting the criteria of drug development. 1 Introduction 2 Bioinspired Total Synthesis of FR901483 3 Non-bioinspired Approaches toward FR901483 4 Various Tactics for Accessing the Core Skeleton 5 Challenges for Efficiency [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Synthesis is the property of Georg Thieme Verlag Stuttgart and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=136507872 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1055/s-0037-1611779 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 2237 Subjects: – SubjectFull: Drug development Type: general – SubjectFull: Alkaloids Type: general – SubjectFull: Antimetabolites Type: general – SubjectFull: Skeleton Type: general Titles: – TitleFull: FR901483: Synthetic Efficiency Remains a Challenge. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ruan, Zhuwei – PersonEntity: Name: NameFull: Li, Cheng – PersonEntity: Name: NameFull: Shen, Defeng – PersonEntity: Name: NameFull: Huang, Sha-Hua – PersonEntity: Name: NameFull: Hong, Ran IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 00397881 Numbering: – Type: volume Value: 51 – Type: issue Value: 11 Titles: – TitleFull: Synthesis Type: main |
| ResultId | 1 |
