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Signal amplification strategies for paper-based analytical devices.

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Title: Signal amplification strategies for paper-based analytical devices.
Authors: Liu, Linyang1,2 (AUTHOR), Yang, Danting1,2,3 (AUTHOR), Liu, Guozhen1,2,4 (AUTHOR) guozhen.liu@unsw.edu.au
Source: Biosensors & Bioelectronics. Jul2019, Vol. 136, p60-75. 16p.
Subjects: Microfluidic devices, Life sciences, Nucleic acids, Molecular spectra, Point-of-care testing, Engineering design
Abstract: Paper-based analytical devices (PADs) are very popular for point-of-care diagnostics, which provide a fast, cost-effective and possible multiplexed detection of a spectrum of molecules. They have been matching forward proudly to contribute to the modern analytical science and life science. Accompanying with their advantages and huge potentials, low detection sensitivity is continuing to challenge the application of PADs from bench to bedside. In order to improve the sensitivity and enhance the signal readout, variable signal amplification strategies have been investigated and applied for PADs. In this review, we have firstly classified formats of PADs according to the engineering design. Advances for improving sensitivity of PADs in recent five years are then summarised according to three popular types of signal amplification strategies (nanomaterial based, nucleic acid based, and engineering of PADs based). Pros and cons of each signal amplification approach have been discussed accordingly. Finally, the future perspectives of PADs are proposed. • Advances on signal amplification strategies to enhance sensitivity of paper based analytical devices (PADs) are outlined. • Three signal amplification strategies (nanomaterial, nucleic acid, and engineering of PADs based) are discussed. • The pros and cons of different signal amplification strategies are compared. • Future perspectives for signal amplification on PADs are proposed. [ABSTRACT FROM AUTHOR]
Copyright of Biosensors & Bioelectronics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Signal amplification strategies for paper-based analytical devices.
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  Data: <searchLink fieldCode="AR" term="%22Liu%2C+Linyang%22">Liu, Linyang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Danting%22">Yang, Danting</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Guozhen%22">Liu, Guozhen</searchLink><relatesTo>1,2,4</relatesTo> (AUTHOR)<i> guozhen.liu@unsw.edu.au</i>
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  Data: <searchLink fieldCode="JN" term="%22Biosensors+%26+Bioelectronics%22">Biosensors & Bioelectronics</searchLink>. Jul2019, Vol. 136, p60-75. 16p.
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  Data: <searchLink fieldCode="DE" term="%22Microfluidic+devices%22">Microfluidic devices</searchLink><br /><searchLink fieldCode="DE" term="%22Life+sciences%22">Life sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Nucleic+acids%22">Nucleic acids</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+spectra%22">Molecular spectra</searchLink><br /><searchLink fieldCode="DE" term="%22Point-of-care+testing%22">Point-of-care testing</searchLink><br /><searchLink fieldCode="DE" term="%22Engineering+design%22">Engineering design</searchLink>
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  Label: Abstract
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  Data: Paper-based analytical devices (PADs) are very popular for point-of-care diagnostics, which provide a fast, cost-effective and possible multiplexed detection of a spectrum of molecules. They have been matching forward proudly to contribute to the modern analytical science and life science. Accompanying with their advantages and huge potentials, low detection sensitivity is continuing to challenge the application of PADs from bench to bedside. In order to improve the sensitivity and enhance the signal readout, variable signal amplification strategies have been investigated and applied for PADs. In this review, we have firstly classified formats of PADs according to the engineering design. Advances for improving sensitivity of PADs in recent five years are then summarised according to three popular types of signal amplification strategies (nanomaterial based, nucleic acid based, and engineering of PADs based). Pros and cons of each signal amplification approach have been discussed accordingly. Finally, the future perspectives of PADs are proposed. • Advances on signal amplification strategies to enhance sensitivity of paper based analytical devices (PADs) are outlined. • Three signal amplification strategies (nanomaterial, nucleic acid, and engineering of PADs based) are discussed. • The pros and cons of different signal amplification strategies are compared. • Future perspectives for signal amplification on PADs are proposed. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biosensors & Bioelectronics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.bios.2019.04.043
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      – Code: eng
        Text: English
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        PageCount: 16
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        Type: general
      – SubjectFull: Life sciences
        Type: general
      – SubjectFull: Nucleic acids
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      – SubjectFull: Molecular spectra
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      – SubjectFull: Point-of-care testing
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      – SubjectFull: Engineering design
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      – TitleFull: Signal amplification strategies for paper-based analytical devices.
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            NameFull: Liu, Linyang
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            NameFull: Yang, Danting
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            NameFull: Liu, Guozhen
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            – D: 01
              M: 07
              Text: Jul2019
              Type: published
              Y: 2019
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