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PCSK9: A new participant in lipophagy in regulating atherosclerosis?

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Title: PCSK9: A new participant in lipophagy in regulating atherosclerosis?
Authors: Xiao, Jun1 (AUTHOR), Deng, Yi-Min1 (AUTHOR), Liu, Xiang-Rui1 (AUTHOR), Cao, Jian-Ping1 (AUTHOR), Zhou, Min1 (AUTHOR), Tang, Ya-Ling1 (AUTHOR), Xiong, Wen-Hao1 (AUTHOR), Jiang, Zhi-Sheng1 (AUTHOR), Tang, Zhi-Han1 (AUTHOR) Tangzhihan98@163.com, Liu, Lu-Shan1 (AUTHOR) liuls2000@163.com
Source: Clinica Chimica Acta. Aug2019, Vol. 495, p358-364. 7p.
Subjects: Lipid metabolism, Lysosomes, Low density lipoprotein receptors, Lipoprotein receptors, Atherosclerosis
Abstract: Proprotein convertase subtilisin kexin 9 (PCSK9) regulates lipid metabolism by degrading low-density lipoprotein receptor on the surface of hepatocytes. PCSK9-mediated lipid degradation is associated with lipophagy. Lipophagy is a process by which autophagosomes selectively sequester lipid-droplet-stored lipids and are delivered to lysosomes for degradation. Lipophagy was first discovered in hepatocytes, and its occurrence provides important fundamental insights into how lipid metabolism regulates cellular physiology and pathophysiology. Furthermore, PCSK9 may regulate lipid levels by affecting lipophagy. This review will discuss recent advances by which PCSK9 mediates lipid degradation via the lipophagy pathway and present lipophagy as a potential therapeutic target for atherosclerosis. • Atherosclerosis is a chronic inflammatory disease characterized by lipid accumulation; • Lipophagy plays an important role in the prevention of atherosclerosis by removing excessive lipids; • PCSK9 participates in lipid metabolism through the lipophagy pathway, and thus affects atherosclerosis. [ABSTRACT FROM AUTHOR]
Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
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DbLabel: Engineering Source
An: 137072866
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: PCSK9: A new participant in lipophagy in regulating atherosclerosis?
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  Data: <searchLink fieldCode="AR" term="%22Xiao%2C+Jun%22">Xiao, Jun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deng%2C+Yi-Min%22">Deng, Yi-Min</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Xiang-Rui%22">Liu, Xiang-Rui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cao%2C+Jian-Ping%22">Cao, Jian-Ping</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Min%22">Zhou, Min</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Ya-Ling%22">Tang, Ya-Ling</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xiong%2C+Wen-Hao%22">Xiong, Wen-Hao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Zhi-Sheng%22">Jiang, Zhi-Sheng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Zhi-Han%22">Tang, Zhi-Han</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> Tangzhihan98@163.com</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Lu-Shan%22">Liu, Lu-Shan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> liuls2000@163.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Clinica+Chimica+Acta%22">Clinica Chimica Acta</searchLink>. Aug2019, Vol. 495, p358-364. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Lipid+metabolism%22">Lipid metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Lysosomes%22">Lysosomes</searchLink><br /><searchLink fieldCode="DE" term="%22Low+density+lipoprotein+receptors%22">Low density lipoprotein receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Lipoprotein+receptors%22">Lipoprotein receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Atherosclerosis%22">Atherosclerosis</searchLink>
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  Label: Abstract
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  Data: Proprotein convertase subtilisin kexin 9 (PCSK9) regulates lipid metabolism by degrading low-density lipoprotein receptor on the surface of hepatocytes. PCSK9-mediated lipid degradation is associated with lipophagy. Lipophagy is a process by which autophagosomes selectively sequester lipid-droplet-stored lipids and are delivered to lysosomes for degradation. Lipophagy was first discovered in hepatocytes, and its occurrence provides important fundamental insights into how lipid metabolism regulates cellular physiology and pathophysiology. Furthermore, PCSK9 may regulate lipid levels by affecting lipophagy. This review will discuss recent advances by which PCSK9 mediates lipid degradation via the lipophagy pathway and present lipophagy as a potential therapeutic target for atherosclerosis. • Atherosclerosis is a chronic inflammatory disease characterized by lipid accumulation; • Lipophagy plays an important role in the prevention of atherosclerosis by removing excessive lipids; • PCSK9 participates in lipid metabolism through the lipophagy pathway, and thus affects atherosclerosis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.cca.2019.05.005
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        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 358
    Subjects:
      – SubjectFull: Lipid metabolism
        Type: general
      – SubjectFull: Lysosomes
        Type: general
      – SubjectFull: Low density lipoprotein receptors
        Type: general
      – SubjectFull: Lipoprotein receptors
        Type: general
      – SubjectFull: Atherosclerosis
        Type: general
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      – TitleFull: PCSK9: A new participant in lipophagy in regulating atherosclerosis?
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              M: 08
              Text: Aug2019
              Type: published
              Y: 2019
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