Standardized assessment of the signal intensity increase on unenhanced T1-weighted images in the brain: the European Gadolinium Retention Evaluation Consortium (GREC) Task Force position statement.
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| Title: | Standardized assessment of the signal intensity increase on unenhanced T1-weighted images in the brain: the European Gadolinium Retention Evaluation Consortium (GREC) Task Force position statement. |
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| Authors: | Quattrocchi, Carlo C.1 (AUTHOR) c.quattrocchi@unicampus.it, Ramalho, Joana2 (AUTHOR), van der Molen, Aart J.3 (AUTHOR), Rovira, Àlex4 (AUTHOR), Radbruch, Alexander5 (AUTHOR), GREC, European Gadolinium Retention Evaluation Consortium and the ESNR, European Society of Neuroradiology (CORPORATE AUTHOR) |
| Source: | European Radiology. Aug2019, Vol. 29 Issue 8, p3959-3967. 9p. 2 Charts, 1 Graph. |
| Subjects: | Task forces, Gadolinium, Brain imaging, Dentate nucleus, Magnetic resonance imaging, Brain, Medical societies, Ferrans & Powers Quality of Life Index, Contrast media |
| Geographic Terms: | Europe |
| Abstract: | After the initial report in 2014 on T1-weighted (T1w) hyperintensity of deep brain nuclei following serial injections of linear gadolinium-based contrast agents (GBCAs), a multitude of studies on the potential of the marketed GBCAs to cause T1w hyperintensity in the brain have been published. The vast majority of these studies found a signal intensity (SI) increase for linear GBCAs in the brain-first and foremost in the dentate nucleus-while no SI increase was found for macrocyclic GBCAs. However, the scientific debate about this finding is kept alive by the fact that SI differences do not unequivocally represent the amount of gadolinium retained. Since the study design of the SI measurement in various brain structures is relatively simple, MRI studies investigating gadolinium-dependent T1w hyperintensity are currently conducted at multiple institutions worldwide. However, methodological mistakes may result in flawed conclusions. In this position statement, we assess the methodological basis of the published retrospective studies and define quality standards for future studies to give guidance to the scientific community and to help identify studies with potentially flawed methodology and misleading results. KEY POINTS: • A multitude of studies has been published on the potential of the marketed GBCAs to cause T1w hyperintensity in the brain. • The gadolinium-dependent T1w hyperintensity in the brain depends on patient's history, types of GBCAs used (i.e., linear vs. macrocyclic GBCAs) and MR imaging setup and protocols. • Quality standards for the design of future studies are needed to standardize methodology and avoid potentially misleading results from retrospective studies. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 137304082 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Standardized assessment of the signal intensity increase on unenhanced T1-weighted images in the brain: the European Gadolinium Retention Evaluation Consortium (GREC) Task Force position statement. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Quattrocchi%2C+Carlo+C%2E%22">Quattrocchi, Carlo C.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> c.quattrocchi@unicampus.it</i><br /><searchLink fieldCode="AR" term="%22Ramalho%2C+Joana%22">Ramalho, Joana</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+der+Molen%2C+Aart+J%2E%22">van der Molen, Aart J.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rovira%2C+Àlex%22">Rovira, Àlex</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Radbruch%2C+Alexander%22">Radbruch, Alexander</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22GREC%2C+European+Gadolinium+Retention+Evaluation+Consortium+and+the+ESNR%2C+European+Society+of+Neuroradiology%22">GREC, European Gadolinium Retention Evaluation Consortium and the ESNR, European Society of Neuroradiology</searchLink> (CORPORATE AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Aug2019, Vol. 29 Issue 8, p3959-3967. 9p. 2 Charts, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Task+forces%22">Task forces</searchLink><br /><searchLink fieldCode="DE" term="%22Gadolinium%22">Gadolinium</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Dentate+nucleus%22">Dentate nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+societies%22">Medical societies</searchLink><br /><searchLink fieldCode="DE" term="%22Ferrans+%26+Powers+Quality+of+Life+Index%22">Ferrans & Powers Quality of Life Index</searchLink><br /><searchLink fieldCode="DE" term="%22Contrast+media%22">Contrast media</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Europe%22">Europe</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: After the initial report in 2014 on T1-weighted (T1w) hyperintensity of deep brain nuclei following serial injections of linear gadolinium-based contrast agents (GBCAs), a multitude of studies on the potential of the marketed GBCAs to cause T1w hyperintensity in the brain have been published. The vast majority of these studies found a signal intensity (SI) increase for linear GBCAs in the brain-first and foremost in the dentate nucleus-while no SI increase was found for macrocyclic GBCAs. However, the scientific debate about this finding is kept alive by the fact that SI differences do not unequivocally represent the amount of gadolinium retained. Since the study design of the SI measurement in various brain structures is relatively simple, MRI studies investigating gadolinium-dependent T1w hyperintensity are currently conducted at multiple institutions worldwide. However, methodological mistakes may result in flawed conclusions. In this position statement, we assess the methodological basis of the published retrospective studies and define quality standards for future studies to give guidance to the scientific community and to help identify studies with potentially flawed methodology and misleading results. KEY POINTS: • A multitude of studies has been published on the potential of the marketed GBCAs to cause T1w hyperintensity in the brain. • The gadolinium-dependent T1w hyperintensity in the brain depends on patient's history, types of GBCAs used (i.e., linear vs. macrocyclic GBCAs) and MR imaging setup and protocols. • Quality standards for the design of future studies are needed to standardize methodology and avoid potentially misleading results from retrospective studies. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-018-5803-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 3959 Subjects: – SubjectFull: Task forces Type: general – SubjectFull: Gadolinium Type: general – SubjectFull: Brain imaging Type: general – SubjectFull: Dentate nucleus Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Brain Type: general – SubjectFull: Medical societies Type: general – SubjectFull: Ferrans & Powers Quality of Life Index Type: general – SubjectFull: Contrast media Type: general – SubjectFull: Europe Type: general Titles: – TitleFull: Standardized assessment of the signal intensity increase on unenhanced T1-weighted images in the brain: the European Gadolinium Retention Evaluation Consortium (GREC) Task Force position statement. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Quattrocchi, Carlo C. – PersonEntity: Name: NameFull: Ramalho, Joana – PersonEntity: Name: NameFull: van der Molen, Aart J. – PersonEntity: Name: NameFull: Rovira, Àlex – PersonEntity: Name: NameFull: Radbruch, Alexander – PersonEntity: Name: NameFull: GREC, European Gadolinium Retention Evaluation Consortium and the ESNR, European Society of Neuroradiology IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 29 – Type: issue Value: 8 Titles: – TitleFull: European Radiology Type: main |
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