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Quantitative neuromuscular ultrasound analysis as biomarkers in amyotrophic lateral sclerosis.

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Title: Quantitative neuromuscular ultrasound analysis as biomarkers in amyotrophic lateral sclerosis.
Authors: Ríos-Díaz, José1,2 (AUTHOR), del Baño-Aledo, María Elena3 (AUTHOR) mbano@um.es, Tembl-Ferrairó, José I.4 (AUTHOR), Chumillas, Maria J.4,5,6 (AUTHOR), Vázquez-Costa, Juan F.5,6,7 (AUTHOR), Martínez-Payá, Jacinto J.3 (AUTHOR)
Source: European Radiology. Aug2019, Vol. 29 Issue 8, p4266-4275. 10p. 2 Color Photographs, 4 Charts, 1 Graph.
Subjects: Amyotrophic lateral sclerosis, Muscle strength, Median nerve
Abstract: Objectives: To assess the differences in morphological and texture parameters of median nerve (MN) and abductor pollicis brevis (APB) between amyotrophic lateral sclerosis (ALS) patients and controls.Methods: The cross-sectional area (CSA) of the MN and the muscle thickness (MTh) of APB were measured bilaterally in 59 recently diagnosed ALS patients and 20 matched healthy controls. Echointensity (EI), echovariation (EV) and grey-level co-occurrence matrix (GLCM) texture features of both structures were also analysed. Correlations between these parameters and clinical variables (muscle strength and disability) were analysed.Results: The CSA of MN was significantly lower in ALS patients (MD = - 1.83 mm2 [95% CI = 2.89; - 0.77 mm2]; p = 0.01). ALS patients showed significantly lower MTh (- 2.23 mm [3.16; - 1.30 mm]; p < 0.001) and EV (- 7.40 [11.5; - 3.33]; p = 0.004) and higher EI (21.2 [11.9; 30.6]; p < 0.001) in the APB muscle. No relevant differences were detected in GLCM features for this muscle. The model including all parameters (CSA for MN and MTh, EI and EV for APB) showed an AUC of 82% (sensitivity 87%; specificity 42%). Muscle strength and disability correlated with APB muscle ultrasound parameters but not with those of the MN.Conclusions: APB muscle ultrasound biomarkers (especially MTh and EI) showed better discrimination capacity and correlation with clinical variables than MN biomarkers. However, the combination of both biomarkers increased their ability to detect LMN impairment, suggesting that both biomarkers could be used in a complementary manner for the diagnosis and progression monitoring in ALS.Key Points: • Abductor pollicis brevis muscle and median nerve impairment is detectable by ultrasound in amyotrophic lateral sclerosis patients, even in those without clinical impairment. • Muscle ultrasound biomarkers show better discrimination capacity than nerve biomarkers in amyotrophic lateral sclerosis. • Quantitative neuromuscular ultrasound biomarkers could be useful in a general amyotrophic lateral sclerosis population early on the disease. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Quantitative neuromuscular ultrasound analysis as biomarkers in amyotrophic lateral sclerosis.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22R&#237;os-D&#237;az%2C+Jos&#233;%22&quot;&gt;R&#237;os-D&#237;az, Jos&#233;&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22del+Ba&#241;o-Aledo%2C+Mar&#237;a+Elena%22&quot;&gt;del Ba&#241;o-Aledo, Mar&#237;a Elena&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; mbano@um.es&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tembl-Ferrair&#243;%2C+Jos&#233;+I%2E%22&quot;&gt;Tembl-Ferrair&#243;, Jos&#233; I.&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chumillas%2C+Maria+J%2E%22&quot;&gt;Chumillas, Maria J.&lt;/searchLink&gt;&lt;relatesTo&gt;4,5,6&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22V&#225;zquez-Costa%2C+Juan+F%2E%22&quot;&gt;V&#225;zquez-Costa, Juan F.&lt;/searchLink&gt;&lt;relatesTo&gt;5,6,7&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mart&#237;nez-Pay&#225;%2C+Jacinto+J%2E%22&quot;&gt;Mart&#237;nez-Pay&#225;, Jacinto J.&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Aug2019, Vol. 29 Issue 8, p4266-4275. 10p. 2 Color Photographs, 4 Charts, 1 Graph.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Amyotrophic+lateral+sclerosis%22&quot;&gt;Amyotrophic lateral sclerosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Muscle+strength%22&quot;&gt;Muscle strength&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Median+nerve%22&quot;&gt;Median nerve&lt;/searchLink&gt;
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  Label: Abstract
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  Data: &lt;bold&gt;Objectives: &lt;/bold&gt;To assess the differences in morphological and texture parameters of median nerve (MN) and abductor pollicis brevis (APB) between amyotrophic lateral sclerosis (ALS) patients and controls.&lt;bold&gt;Methods: &lt;/bold&gt;The cross-sectional area (CSA) of the MN and the muscle thickness (MTh) of APB were measured bilaterally in 59 recently diagnosed ALS patients and 20 matched healthy controls. Echointensity (EI), echovariation (EV) and grey-level co-occurrence matrix (GLCM) texture features of both structures were also analysed. Correlations between these parameters and clinical variables (muscle strength and disability) were analysed.&lt;bold&gt;Results: &lt;/bold&gt;The CSA of MN was significantly lower in ALS patients (MD&#160;=&#160;- 1.83&#160;mm2 [95% CI&#160;=&#160;2.89; - 0.77&#160;mm2]; p = 0.01). ALS patients showed significantly lower MTh (- 2.23&#160;mm [3.16; - 1.30&#160;mm]; p &lt; 0.001) and EV (- 7.40 [11.5; - 3.33]; p = 0.004) and higher EI (21.2 [11.9; 30.6]; p &lt; 0.001) in the APB muscle. No relevant differences were detected in GLCM features for this muscle. The model including all parameters (CSA for MN and MTh, EI and EV for APB) showed an AUC of 82% (sensitivity 87%; specificity 42%). Muscle strength and disability correlated with APB muscle ultrasound parameters but not with those of the MN.&lt;bold&gt;Conclusions: &lt;/bold&gt;APB muscle ultrasound biomarkers (especially MTh and EI) showed better discrimination capacity and correlation with clinical variables than MN biomarkers. However, the combination of both biomarkers increased their ability to detect LMN impairment, suggesting that both biomarkers could be used in a complementary manner for the diagnosis and progression monitoring in ALS.&lt;bold&gt;Key Points: &lt;/bold&gt;• Abductor pollicis brevis muscle and median nerve impairment is detectable by ultrasound in amyotrophic lateral sclerosis patients, even in those without clinical impairment. • Muscle ultrasound biomarkers show better discrimination capacity than nerve biomarkers in amyotrophic lateral sclerosis. • Quantitative neuromuscular ultrasound biomarkers could be useful in a general amyotrophic lateral sclerosis population early on the disease. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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