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Effects of low-level laser therapy on the organization of articular cartilage in an experimental microcrystalline arthritis model.

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Title: Effects of low-level laser therapy on the organization of articular cartilage in an experimental microcrystalline arthritis model.
Authors: Felizatti, Airton Luiz1, do Bomfim, Fernando Russo Costa1, Bovo, Julia Leme1, de Aro, Andrea Aparecida1, do Amaral, Maria Esméria Corezzola1, Esquisatto, Marcelo Augusto Marretto1 marcelosquisatto@fho.edu.br
Source: Lasers in Medical Science. Sep2019, Vol. 34 Issue 7, p1401-1412. 12p.
Subjects: Articular cartilage, Glycosaminoglycans, Cartilage cells, Hydroxyproline, Knee, Animal experimentation, Apoptosis, Arthritis, Biological models, Bone morphogenetic proteins, Femur, Growth factors, Proteolytic enzymes, Rats, Research funding, Tibia, Physiological effects of radiation
Abstract: The aim of this study was to evaluate the effects of low-level laser therapy using the gallium arsenide laser (λ = 830 nm) on the articular cartilage (AC) organization from knee joint in an experimental model of microcrystalline arthritis in adult male Wistar rats. Seventy-two animals were divided into three groups: A (control), B (induced arthritis), and C (induced arthritis + laser therapy). The arthritis was induced in the right knee using 2 mg of Na4P2O7 in 0.5 mL of saline solution. The treatments were daily applied in the patellar region of the right knee after 48 h of induction. On the 7th, 14th, and 21st days of treatment, the animals were euthanized and their right knees were removed and processed for structural and biochemical analysis of the AC. The chondrocytes positively labeled for the TUNEL reaction were lower in C than in B on the 14th and 21st days. The content of glycosaminoglycans and hydroxyproline in A and C was higher than B on the 21st day. The amount of tibial TNF-α in B and C was lower than in A. The amount of tibial BMP-7 in B and C was higher than in A. The femoral MMP-13 was lower in B and C than for A. The tibial TGF-β for C was higher than the others. The femoral ADAMT-S4 content of A and C presented similar and inferior data to B on the 21st day. The AsGa-830 nm therapy preserved the content of glycosaminoglycans, reduced the cellular changes and the inflammatory process compared to the untreated group. [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Effects of low-level laser therapy on the organization of articular cartilage in an experimental microcrystalline arthritis model.
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  Data: <searchLink fieldCode="AR" term="%22Felizatti%2C+Airton+Luiz%22">Felizatti, Airton Luiz</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22do+Bomfim%2C+Fernando+Russo+Costa%22">do Bomfim, Fernando Russo Costa</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bovo%2C+Julia+Leme%22">Bovo, Julia Leme</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22de+Aro%2C+Andrea+Aparecida%22">de Aro, Andrea Aparecida</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22do+Amaral%2C+Maria+Esméria+Corezzola%22">do Amaral, Maria Esméria Corezzola</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Esquisatto%2C+Marcelo+Augusto+Marretto%22">Esquisatto, Marcelo Augusto Marretto</searchLink><relatesTo>1</relatesTo><i> marcelosquisatto@fho.edu.br</i>
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  Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. Sep2019, Vol. 34 Issue 7, p1401-1412. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Articular+cartilage%22">Articular cartilage</searchLink><br /><searchLink fieldCode="DE" term="%22Glycosaminoglycans%22">Glycosaminoglycans</searchLink><br /><searchLink fieldCode="DE" term="%22Cartilage+cells%22">Cartilage cells</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxyproline%22">Hydroxyproline</searchLink><br /><searchLink fieldCode="DE" term="%22Knee%22">Knee</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+experimentation%22">Animal experimentation</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Arthritis%22">Arthritis</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+models%22">Biological models</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+morphogenetic+proteins%22">Bone morphogenetic proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Femur%22">Femur</searchLink><br /><searchLink fieldCode="DE" term="%22Growth+factors%22">Growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22Proteolytic+enzymes%22">Proteolytic enzymes</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Tibia%22">Tibia</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+effects+of+radiation%22">Physiological effects of radiation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The aim of this study was to evaluate the effects of low-level laser therapy using the gallium arsenide laser (λ = 830 nm) on the articular cartilage (AC) organization from knee joint in an experimental model of microcrystalline arthritis in adult male Wistar rats. Seventy-two animals were divided into three groups: A (control), B (induced arthritis), and C (induced arthritis + laser therapy). The arthritis was induced in the right knee using 2 mg of Na4P2O7 in 0.5 mL of saline solution. The treatments were daily applied in the patellar region of the right knee after 48 h of induction. On the 7th, 14th, and 21st days of treatment, the animals were euthanized and their right knees were removed and processed for structural and biochemical analysis of the AC. The chondrocytes positively labeled for the TUNEL reaction were lower in C than in B on the 14th and 21st days. The content of glycosaminoglycans and hydroxyproline in A and C was higher than B on the 21st day. The amount of tibial TNF-α in B and C was lower than in A. The amount of tibial BMP-7 in B and C was higher than in A. The femoral MMP-13 was lower in B and C than for A. The tibial TGF-β for C was higher than the others. The femoral ADAMT-S4 content of A and C presented similar and inferior data to B on the 21st day. The AsGa-830 nm therapy preserved the content of glycosaminoglycans, reduced the cellular changes and the inflammatory process compared to the untreated group. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1007/s10103-019-02740-5
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 12
        StartPage: 1401
    Subjects:
      – SubjectFull: Articular cartilage
        Type: general
      – SubjectFull: Glycosaminoglycans
        Type: general
      – SubjectFull: Cartilage cells
        Type: general
      – SubjectFull: Hydroxyproline
        Type: general
      – SubjectFull: Knee
        Type: general
      – SubjectFull: Animal experimentation
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      – SubjectFull: Apoptosis
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      – SubjectFull: Arthritis
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      – SubjectFull: Biological models
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      – SubjectFull: Bone morphogenetic proteins
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      – SubjectFull: Femur
        Type: general
      – SubjectFull: Growth factors
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      – SubjectFull: Proteolytic enzymes
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      – SubjectFull: Physiological effects of radiation
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    Titles:
      – TitleFull: Effects of low-level laser therapy on the organization of articular cartilage in an experimental microcrystalline arthritis model.
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              M: 09
              Text: Sep2019
              Type: published
              Y: 2019
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