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Tricuspid valve leaflet strains in the beating ovine heart.

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Title: Tricuspid valve leaflet strains in the beating ovine heart.
Authors: Mathur, M.1 (AUTHOR), Jazwiec, T.2,3 (AUTHOR), Meador, W. D.4 (AUTHOR), Malinowski, M.2,5 (AUTHOR), Goehler, M.2 (AUTHOR), Ferguson, H.2 (AUTHOR), Timek, T. A.2 (AUTHOR), Rausch, M. K.4,6,7 (AUTHOR) manuel.rausch@utexas.edu
Source: Biomechanics & Modeling in Mechanobiology. Oct2019, Vol. 18 Issue 5, p1351-1361. 11p.
Subjects: Tricuspid valve, Mitral valve, Heart beat, Pamphlets, Eigenfunctions, Medical equipment
Abstract: The tricuspid leaflets coapt during systole to facilitate proper valve function and, thus, ensure efficient transport of deoxygenated blood to the lungs. Between their open state and closed state, the leaflets undergo large deformations. Quantification of these deformations is important for our basic scientific understanding of tricuspid valve function and for diagnostic or prognostic purposes. To date, tricuspid valve leaflet strains have never been directly quantified in vivo. To fill this gap in our knowledge, we implanted four sonomicrometry crystals per tricuspid leaflet and six crystals along the tricuspid annulus in a total of five sheep. In the beating ovine hearts, we recorded crystal coordinates alongside hemodynamic data. Once recorded, we used a finite strain kinematic framework to compute the temporal evolutions of area strain, radial strain, and circumferential strain for each leaflet. We found that leaflet strains were larger in the anterior leaflet than the posterior and septal leaflets. Additionally, we found that radial strains were larger than circumferential strains. Area strains were as large as 97% in the anterior leaflet, 31% in the posterior leaflet, and 31% in the septal leaflet. These data suggest that tricuspid valve leaflet strains are significantly larger than those in the mitral valve. Should our findings be confirmed they could suggest either that the mechanobiological equilibrium of tricuspid valve resident cells is different than that of mitral valve resident cells or that the mechanotransductive apparatus between the two varies. Either phenomenon may have important implications for the development of tricuspid valve-specific surgical techniques and medical devices. [ABSTRACT FROM AUTHOR]
Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Tricuspid valve leaflet strains in the beating ovine heart.
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  Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Oct2019, Vol. 18 Issue 5, p1351-1361. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Tricuspid+valve%22">Tricuspid valve</searchLink><br /><searchLink fieldCode="DE" term="%22Mitral+valve%22">Mitral valve</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+beat%22">Heart beat</searchLink><br /><searchLink fieldCode="DE" term="%22Pamphlets%22">Pamphlets</searchLink><br /><searchLink fieldCode="DE" term="%22Eigenfunctions%22">Eigenfunctions</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+equipment%22">Medical equipment</searchLink>
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  Data: The tricuspid leaflets coapt during systole to facilitate proper valve function and, thus, ensure efficient transport of deoxygenated blood to the lungs. Between their open state and closed state, the leaflets undergo large deformations. Quantification of these deformations is important for our basic scientific understanding of tricuspid valve function and for diagnostic or prognostic purposes. To date, tricuspid valve leaflet strains have never been directly quantified in vivo. To fill this gap in our knowledge, we implanted four sonomicrometry crystals per tricuspid leaflet and six crystals along the tricuspid annulus in a total of five sheep. In the beating ovine hearts, we recorded crystal coordinates alongside hemodynamic data. Once recorded, we used a finite strain kinematic framework to compute the temporal evolutions of area strain, radial strain, and circumferential strain for each leaflet. We found that leaflet strains were larger in the anterior leaflet than the posterior and septal leaflets. Additionally, we found that radial strains were larger than circumferential strains. Area strains were as large as 97% in the anterior leaflet, 31% in the posterior leaflet, and 31% in the septal leaflet. These data suggest that tricuspid valve leaflet strains are significantly larger than those in the mitral valve. Should our findings be confirmed they could suggest either that the mechanobiological equilibrium of tricuspid valve resident cells is different than that of mitral valve resident cells or that the mechanotransductive apparatus between the two varies. Either phenomenon may have important implications for the development of tricuspid valve-specific surgical techniques and medical devices. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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