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Poly(amino acid)-grafted polymacrolactones. Synthesis, self-assembling and ionic coupling properties.

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Title: Poly(amino acid)-grafted polymacrolactones. Synthesis, self-assembling and ionic coupling properties.
Authors: Tinajero-Díaz, E.1 (AUTHOR), Martínez de Ilarduya, A.1 (AUTHOR), Cavanagh, B.1 (AUTHOR), Heise, A.1 (AUTHOR), Muñoz-Guerra, S.1 (AUTHOR) sebastian.munoz@upc.edu
Source: Reactive & Functional Polymers. Oct2019, Vol. 143, pN.PAG-N.PAG. 1p.
Subjects: Graft copolymers, Amino acids, Synchrotron radiation, Drug delivery systems, Doxorubicin, Anthracyclines, Cationic polymers, Copolymers
Abstract: Polyglobalide (PGl) with number average polymerization degree of ~20 was prepared by enzymatic ROP and then polyfunctionalized at 60% with aminothioethylene groups. The PGl 20 -(NH 2) 12 copolymer was used as macroinitiator for the ROP of NCAs of BLG (γ-benzyl L-glutamate) and ZLL (ε N -carbobenzoxy- l -lysine) protected amino acids to produce neutral polypeptide- graft ed polyglobalides poly[Gl 20 - graft -(AA) z ] with z = 5 and 12, which upon deprotection, afforded anionic and cationic copolymers, respectively. Both protected and deprotected graft copolymers were characterized in full detail by NMR, and their thermal properties were evaluated by TGA and DSC. The structure of these copolymers in the solid-state was examined by FTIR and XRD using synchrotron radiation. All grafted polyglobalides were amorphous but the polypeptide side chains were arranged in either alpha-helix or beta-sheet conformation, and reliable indications on the occurrence of supramolecular structures were frequently found. The capacity of poly[Gl 20 - graft -(AA) z ] copolymers to self-assemble in aqueous medium was evidenced by the preparation of well-shaped spheroidal nanoparticles with a diversity of sizes depending on copolymer composition and charge. Loading and release of doxorubicin (DOX) from nanoparticles made of negatively charged poly[Gl 20 - graft -(LGA) 12 ] as well as DNA complexation with cationic poly[Gl 20 - graft -(LL) 5 ] were explored to appraise the potential of these copolymers for building drug delivery systems. [ABSTRACT FROM AUTHOR]
Copyright of Reactive & Functional Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Poly(amino acid)-grafted polymacrolactones. Synthesis, self-assembling and ionic coupling properties.
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  Data: <searchLink fieldCode="AR" term="%22Tinajero-Díaz%2C+E%2E%22">Tinajero-Díaz, E.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martínez+de+Ilarduya%2C+A%2E%22">Martínez de Ilarduya, A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cavanagh%2C+B%2E%22">Cavanagh, B.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heise%2C+A%2E%22">Heise, A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Muñoz-Guerra%2C+S%2E%22">Muñoz-Guerra, S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> sebastian.munoz@upc.edu</i>
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  Data: <searchLink fieldCode="DE" term="%22Graft+copolymers%22">Graft copolymers</searchLink><br /><searchLink fieldCode="DE" term="%22Amino+acids%22">Amino acids</searchLink><br /><searchLink fieldCode="DE" term="%22Synchrotron+radiation%22">Synchrotron radiation</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Doxorubicin%22">Doxorubicin</searchLink><br /><searchLink fieldCode="DE" term="%22Anthracyclines%22">Anthracyclines</searchLink><br /><searchLink fieldCode="DE" term="%22Cationic+polymers%22">Cationic polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Copolymers%22">Copolymers</searchLink>
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  Label: Abstract
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  Data: Polyglobalide (PGl) with number average polymerization degree of ~20 was prepared by enzymatic ROP and then polyfunctionalized at 60% with aminothioethylene groups. The PGl 20 -(NH 2) 12 copolymer was used as macroinitiator for the ROP of NCAs of BLG (γ-benzyl L-glutamate) and ZLL (ε N -carbobenzoxy- l -lysine) protected amino acids to produce neutral polypeptide- graft ed polyglobalides poly[Gl 20 - graft -(AA) z ] with z = 5 and 12, which upon deprotection, afforded anionic and cationic copolymers, respectively. Both protected and deprotected graft copolymers were characterized in full detail by NMR, and their thermal properties were evaluated by TGA and DSC. The structure of these copolymers in the solid-state was examined by FTIR and XRD using synchrotron radiation. All grafted polyglobalides were amorphous but the polypeptide side chains were arranged in either alpha-helix or beta-sheet conformation, and reliable indications on the occurrence of supramolecular structures were frequently found. The capacity of poly[Gl 20 - graft -(AA) z ] copolymers to self-assemble in aqueous medium was evidenced by the preparation of well-shaped spheroidal nanoparticles with a diversity of sizes depending on copolymer composition and charge. Loading and release of doxorubicin (DOX) from nanoparticles made of negatively charged poly[Gl 20 - graft -(LGA) 12 ] as well as DNA complexation with cationic poly[Gl 20 - graft -(LL) 5 ] were explored to appraise the potential of these copolymers for building drug delivery systems. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Reactive & Functional Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.reactfunctpolym.2019.104316
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Graft copolymers
        Type: general
      – SubjectFull: Amino acids
        Type: general
      – SubjectFull: Synchrotron radiation
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Doxorubicin
        Type: general
      – SubjectFull: Anthracyclines
        Type: general
      – SubjectFull: Cationic polymers
        Type: general
      – SubjectFull: Copolymers
        Type: general
    Titles:
      – TitleFull: Poly(amino acid)-grafted polymacrolactones. Synthesis, self-assembling and ionic coupling properties.
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            NameFull: Tinajero-Díaz, E.
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            – D: 01
              M: 10
              Text: Oct2019
              Type: published
              Y: 2019
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              Value: 143
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            – TitleFull: Reactive & Functional Polymers
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