View in EDS HTML Full Text PDF Full Text

Poly(Cyclohexene Phthalate) Nanoparticles for Controlled Dasatinib Delivery in Breast Cancer Therapy.

Saved in:
Bibliographic Details
Title: Poly(Cyclohexene Phthalate) Nanoparticles for Controlled Dasatinib Delivery in Breast Cancer Therapy.
Authors: Niza, Enrique1 (AUTHOR), Nieto-Jiménez, Cristina2 (AUTHOR), Noblejas-López, María del Mar2 (AUTHOR), Bravo, Iván3 (AUTHOR), Castro-Osma, José Antonio1 (AUTHOR), de la Cruz-Martínez, Felipe4 (AUTHOR), Martínez de Sarasa Buchaca, Marc4 (AUTHOR), Posadas, Inmaculada5 (AUTHOR), Canales-Vázquez, Jesús6 (AUTHOR), Lara-Sanchez, Agustín4 (AUTHOR), Hermida-Merino, Daniel7 (AUTHOR), Solano, Eduardo8 (AUTHOR), Ocaña, Alberto9 (AUTHOR) albertocana@yahoo.es, Alonso-Moreno, Carlos1 (AUTHOR) albertocana@yahoo.es
Source: Nanomaterials (2079-4991). Sep2019, Vol. 9 Issue 9, p1208. 1p.
Subjects: United States. Food & Drug Administration, Breast cancer, Cancer treatment, Cyclohexene, Drug delivery systems, Treatment effectiveness, Phthalate esters, Dasatinib, Polyesters
Abstract: The effect on the activity in breast cancer models of the small tyrosine kinase inhibitor dasatinib (DAS), either alone or in combination with other antitumoral agents, has been recently explored. However, DAS is characterized by its low and highly pH-dependent solubility, which could lead to poor uptake of the drug limiting its tumoral efficacy. Thus far, the development of safe and efficient delivery vehicles of DAS to improve the therapeutic efficacy minimizing the toxicity profile is still required. In this work, a biodegradable and biocompatible polyester is assessed, for the first time, as raw material for the generation of polymeric nanoparticles (NPs). NPs of 100 nm with a narrow polydispersity were formulated for the encapsulation of DAS. The enzymatic and cellular degradation of the new drug delivery system has been studied, and the toxicity and blood compatibility evaluated for its potential clinical use. The new material used for the generation of nanoparticles led to encapsulate DAS in an efficient manner with quicker release DAS profile when compared with the FDA-approved biopolymer Polylactide. The new DAS-loaded polymeric nanocarrier gave a superior efficacy when compared to free DAS with no difference in the mechanism of action. The new NPs shown to be a promising DAS delivery system to be further evaluated for breast cancer treatment. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 139037220
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Poly(Cyclohexene Phthalate) Nanoparticles for Controlled Dasatinib Delivery in Breast Cancer Therapy.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Niza%2C+Enrique%22">Niza, Enrique</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nieto-Jiménez%2C+Cristina%22">Nieto-Jiménez, Cristina</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Noblejas-López%2C+María+del+Mar%22">Noblejas-López, María del Mar</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bravo%2C+Iván%22">Bravo, Iván</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Castro-Osma%2C+José+Antonio%22">Castro-Osma, José Antonio</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+la+Cruz-Martínez%2C+Felipe%22">de la Cruz-Martínez, Felipe</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martínez+de+Sarasa+Buchaca%2C+Marc%22">Martínez de Sarasa Buchaca, Marc</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Posadas%2C+Inmaculada%22">Posadas, Inmaculada</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Canales-Vázquez%2C+Jesús%22">Canales-Vázquez, Jesús</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lara-Sanchez%2C+Agustín%22">Lara-Sanchez, Agustín</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hermida-Merino%2C+Daniel%22">Hermida-Merino, Daniel</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solano%2C+Eduardo%22">Solano, Eduardo</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ocaña%2C+Alberto%22">Ocaña, Alberto</searchLink><relatesTo>9</relatesTo> (AUTHOR)<i> albertocana@yahoo.es</i><br /><searchLink fieldCode="AR" term="%22Alonso-Moreno%2C+Carlos%22">Alonso-Moreno, Carlos</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> albertocana@yahoo.es</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Sep2019, Vol. 9 Issue 9, p1208. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22United+States%2E+Food+%26+Drug+Administration%22">United States. Food & Drug Administration</searchLink><br /><searchLink fieldCode="DE" term="%22Breast+cancer%22">Breast cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Cyclohexene%22">Cyclohexene</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Phthalate+esters%22">Phthalate esters</searchLink><br /><searchLink fieldCode="DE" term="%22Dasatinib%22">Dasatinib</searchLink><br /><searchLink fieldCode="DE" term="%22Polyesters%22">Polyesters</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The effect on the activity in breast cancer models of the small tyrosine kinase inhibitor dasatinib (DAS), either alone or in combination with other antitumoral agents, has been recently explored. However, DAS is characterized by its low and highly pH-dependent solubility, which could lead to poor uptake of the drug limiting its tumoral efficacy. Thus far, the development of safe and efficient delivery vehicles of DAS to improve the therapeutic efficacy minimizing the toxicity profile is still required. In this work, a biodegradable and biocompatible polyester is assessed, for the first time, as raw material for the generation of polymeric nanoparticles (NPs). NPs of 100 nm with a narrow polydispersity were formulated for the encapsulation of DAS. The enzymatic and cellular degradation of the new drug delivery system has been studied, and the toxicity and blood compatibility evaluated for its potential clinical use. The new material used for the generation of nanoparticles led to encapsulate DAS in an efficient manner with quicker release DAS profile when compared with the FDA-approved biopolymer Polylactide. The new DAS-loaded polymeric nanocarrier gave a superior efficacy when compared to free DAS with no difference in the mechanism of action. The new NPs shown to be a promising DAS delivery system to be further evaluated for breast cancer treatment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=139037220
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/nano9091208
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: 1208
    Subjects:
      – SubjectFull: United States. Food & Drug Administration
        Type: general
      – SubjectFull: Breast cancer
        Type: general
      – SubjectFull: Cancer treatment
        Type: general
      – SubjectFull: Cyclohexene
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Phthalate esters
        Type: general
      – SubjectFull: Dasatinib
        Type: general
      – SubjectFull: Polyesters
        Type: general
    Titles:
      – TitleFull: Poly(Cyclohexene Phthalate) Nanoparticles for Controlled Dasatinib Delivery in Breast Cancer Therapy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Niza, Enrique
      – PersonEntity:
          Name:
            NameFull: Nieto-Jiménez, Cristina
      – PersonEntity:
          Name:
            NameFull: Noblejas-López, María del Mar
      – PersonEntity:
          Name:
            NameFull: Bravo, Iván
      – PersonEntity:
          Name:
            NameFull: Castro-Osma, José Antonio
      – PersonEntity:
          Name:
            NameFull: de la Cruz-Martínez, Felipe
      – PersonEntity:
          Name:
            NameFull: Martínez de Sarasa Buchaca, Marc
      – PersonEntity:
          Name:
            NameFull: Posadas, Inmaculada
      – PersonEntity:
          Name:
            NameFull: Canales-Vázquez, Jesús
      – PersonEntity:
          Name:
            NameFull: Lara-Sanchez, Agustín
      – PersonEntity:
          Name:
            NameFull: Hermida-Merino, Daniel
      – PersonEntity:
          Name:
            NameFull: Solano, Eduardo
      – PersonEntity:
          Name:
            NameFull: Ocaña, Alberto
      – PersonEntity:
          Name:
            NameFull: Alonso-Moreno, Carlos
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: Sep2019
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-print
              Value: 20794991
          Numbering:
            – Type: volume
              Value: 9
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: Nanomaterials (2079-4991)
              Type: main
ResultId 1