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Novel secoeunicellins produced by an octocoral Cladiella sp.

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Title: Novel secoeunicellins produced by an octocoral Cladiella sp.
Authors: Zhang, Zhi-Jun1,2 (AUTHOR), Wang, Yi-Hsuan1,3 (AUTHOR), Chen, Shu-Rong4 (AUTHOR), Peng, Bo-Rong2 (AUTHOR), Yang, San-Nan5 (AUTHOR), Hu, Chiung-Chih2 (AUTHOR), Fang, Lee-Shing6,7 (AUTHOR), Hwang, Tsong-Long1,3,8,9,10 (AUTHOR) htl@mail.cgu.edu.tw, Sung, Ping-Jyun1,2,4,11,12 (AUTHOR) pjsung@nmmba.gov.tw
Source: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2019, Vol. 60 Issue 49, pN.PAG-N.PAG. 1p.
Subjects: Methoxy group, Superoxides
Abstract: • New 6,7-secoeunicellins, cladieunicellins W (1) and X (2), were obtained from Cladiella sp. • Secoeunicellin 2 displayed significant anti-inflammatory activity. • A methoxy group played an important role in determining the activity. Two novel 6,7-secoeunicellins, cladieunicellins W (1) and X (2), along with a known eunicellin, klymollin Y (3), were isolated from an octocoral identified as Cladiella sp. The structures of secoeunicellins 1 and 2 were elucidated by spectroscopic methods. 1 is the first secoeunicellin possessing a γ-lactone ring and 2 represents the first secoeunicellin possessing two tetrahydrofuran moieties. Secoeunicellin 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase. These results implied that the methoxy group at C-6 in 2 plays an important role in determining the activity of these compounds. [ABSTRACT FROM AUTHOR]
Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 139747016
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  Data: Novel secoeunicellins produced by an octocoral Cladiella sp.
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  Data: • New 6,7-secoeunicellins, cladieunicellins W (1) and X (2), were obtained from Cladiella sp. • Secoeunicellin 2 displayed significant anti-inflammatory activity. • A methoxy group played an important role in determining the activity. Two novel 6,7-secoeunicellins, cladieunicellins W (1) and X (2), along with a known eunicellin, klymollin Y (3), were isolated from an octocoral identified as Cladiella sp. The structures of secoeunicellins 1 and 2 were elucidated by spectroscopic methods. 1 is the first secoeunicellin possessing a γ-lactone ring and 2 represents the first secoeunicellin possessing two tetrahydrofuran moieties. Secoeunicellin 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase. These results implied that the methoxy group at C-6 in 2 plays an important role in determining the activity of these compounds. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.tetlet.2019.151300
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        Text: English
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      – SubjectFull: Methoxy group
        Type: general
      – SubjectFull: Superoxides
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    Titles:
      – TitleFull: Novel secoeunicellins produced by an octocoral Cladiella sp.
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            NameFull: Zhang, Zhi-Jun
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            NameFull: Chen, Shu-Rong
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            NameFull: Peng, Bo-Rong
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            NameFull: Yang, San-Nan
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              M: 12
              Text: Dec2019
              Type: published
              Y: 2019
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              Value: 60
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              Value: 49
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