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Fabrication and properties of zirconia/hydroxyapatite composite scaffold based on digital light processing.

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Title: Fabrication and properties of zirconia/hydroxyapatite composite scaffold based on digital light processing.
Authors: Cao, Ying1 (AUTHOR), Shi, Tianshu1,2 (AUTHOR), Jiao, Chen1 (AUTHOR), Liang, Huixin1 (AUTHOR), Chen, Ruoyu1 (AUTHOR), Tian, Zongjun1,3 (AUTHOR) tianzj@nuaa.edu.cn, Zou, Anchao1 (AUTHOR), Yang, Youwen4 (AUTHOR), Wei, Zhen5 (AUTHOR), Wang, Changjiang6 (AUTHOR), Shen, Lida1 (AUTHOR) ldshen@nuaa.edu.cn
Source: Ceramics International. Feb2020, Vol. 46 Issue 2, p2300-2308. 9p.
Subjects: Zirconium oxide, Cancellous bone, Fracture healing, Calcium phosphate, Compressive strength, Performance technology
Abstract: Zirconia and hydroxyapatite(HA) are two typical implant materials, which have the advantages of excellent mechanical strength and good biological activity respectively. It was found that composite material had good biocompatibility and mechanical strength compared to the single material. In this paper, the porous scaffolds of ZrO 2 /HA composite were formed by digital light processing (DLP) technology and their performance were evaluated. Cell experiments showed that the addition of HA had a positive effect on cell proliferation and differentiation. Mechanical tests showed that the composite scaffold with 10 wt% HA had the best compressive capacity due to the pinning and bridging effect of a small amount of HA grains. When scaffolds were immersed in the simulated body fluid (SBF), the compressive strengths of the composite scaffolds decreased within the first 14 days and gradually increased after 14 days. The reason for this phenomenon was the degradation of calcium phosphate components and the deposition of apatite. By the 28th day, the compressive strengths of all the composite scaffolds increased to over 20 MPa, close to that of the zirconia scaffolds during the same period (25 MPa). The compressive strengths of all scaffolds met the requirement of cancellous bone during the entire soaking period, and the composite scaffolds have potential application value in bone repair. [ABSTRACT FROM AUTHOR]
Copyright of Ceramics International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 139783396
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PubTypeId: academicJournal
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  Data: Fabrication and properties of zirconia/hydroxyapatite composite scaffold based on digital light processing.
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  Data: <searchLink fieldCode="AR" term="%22Cao%2C+Ying%22">Cao, Ying</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Tianshu%22">Shi, Tianshu</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiao%2C+Chen%22">Jiao, Chen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liang%2C+Huixin%22">Liang, Huixin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Ruoyu%22">Chen, Ruoyu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tian%2C+Zongjun%22">Tian, Zongjun</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> tianzj@nuaa.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zou%2C+Anchao%22">Zou, Anchao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Youwen%22">Yang, Youwen</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wei%2C+Zhen%22">Wei, Zhen</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Changjiang%22">Wang, Changjiang</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Lida%22">Shen, Lida</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ldshen@nuaa.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Ceramics+International%22">Ceramics International</searchLink>. Feb2020, Vol. 46 Issue 2, p2300-2308. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Zirconium+oxide%22">Zirconium oxide</searchLink><br /><searchLink fieldCode="DE" term="%22Cancellous+bone%22">Cancellous bone</searchLink><br /><searchLink fieldCode="DE" term="%22Fracture+healing%22">Fracture healing</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+phosphate%22">Calcium phosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Compressive+strength%22">Compressive strength</searchLink><br /><searchLink fieldCode="DE" term="%22Performance+technology%22">Performance technology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Zirconia and hydroxyapatite(HA) are two typical implant materials, which have the advantages of excellent mechanical strength and good biological activity respectively. It was found that composite material had good biocompatibility and mechanical strength compared to the single material. In this paper, the porous scaffolds of ZrO 2 /HA composite were formed by digital light processing (DLP) technology and their performance were evaluated. Cell experiments showed that the addition of HA had a positive effect on cell proliferation and differentiation. Mechanical tests showed that the composite scaffold with 10 wt% HA had the best compressive capacity due to the pinning and bridging effect of a small amount of HA grains. When scaffolds were immersed in the simulated body fluid (SBF), the compressive strengths of the composite scaffolds decreased within the first 14 days and gradually increased after 14 days. The reason for this phenomenon was the degradation of calcium phosphate components and the deposition of apatite. By the 28th day, the compressive strengths of all the composite scaffolds increased to over 20 MPa, close to that of the zirconia scaffolds during the same period (25 MPa). The compressive strengths of all scaffolds met the requirement of cancellous bone during the entire soaking period, and the composite scaffolds have potential application value in bone repair. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Ceramics International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.ceramint.2019.09.219
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 2300
    Subjects:
      – SubjectFull: Zirconium oxide
        Type: general
      – SubjectFull: Cancellous bone
        Type: general
      – SubjectFull: Fracture healing
        Type: general
      – SubjectFull: Calcium phosphate
        Type: general
      – SubjectFull: Compressive strength
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      – SubjectFull: Performance technology
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      – TitleFull: Fabrication and properties of zirconia/hydroxyapatite composite scaffold based on digital light processing.
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              Text: Feb2020
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              Y: 2020
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