Quantification of whole‐brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2‐based oxygenation calibrations.
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| Title: | Quantification of whole‐brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T |
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| Authors: | Li, Wenbo1,2 (AUTHOR) wli47@jhmi.edu, Xu, Xiang1,2 (AUTHOR), Liu, Peiying1 (AUTHOR), Strouse, John J.3,4 (AUTHOR), Casella, James F.3 (AUTHOR), Lu, Hanzhang1 (AUTHOR), Zijl, Peter C.M.1,2 (AUTHOR), Qin, Qin1,2 (AUTHOR) |
| Source: | Magnetic Resonance in Medicine. Mar2020, Vol. 83 Issue 3, p1066-1080. 15p. |
| Subjects: | Sickle cell anemia, Oxygen consumption, Calibration, Jugular vein, Blood sampling |
| Abstract: | Purpose: To evaluate different T2‐oxygenation calibrations for estimating venous oxygenation in people with sickle cell anemia (SCA). Methods: Blood T2 values were measured at 3 T in the internal jugular veins of 12 healthy volunteers and 11 SCA participants with no history of stroke, recent transfusion, or renal impairment. T2‐oxygenation relationships of both sickled and normal blood samples were calibrated individually and compared with values generated from published models. After converting venous T2 values to venous oxygenation, whole‐brain oxygen extraction fraction and cerebral metabolic rate of oxygen were calculated. Results: Sickle blood samples' oxygenation values calculated from our individual calibrations agreed well with measurements using a blood analyzer, whereas previous T2 calibrations based on normal blood samples showed 13%‐19% underestimation. Meanwhile, oxygenation values calculated from previous grouped T2 calibration for sickle blood agreed well with experimental measurement on averaged values, but showed up to 20% variation for several individual samples. Using individual T2 calibrations, the whole‐brain oxygen extraction fraction and cerebral metabolic rate of oxygen of SCA participants were 0.38 ± 0.08 and 172 ± 42 µmol/min/100 g, respectively, which were comparable to those values measured on healthy volunteers. Conclusion: Our results confirm that sickle blood T2 values not only depend on the hematocrit and oxygenation values, but also on other hematological factors. The individual T2 calibrations minimized the effect of heterogeneity of sickle blood between different SCA populations and improved the accuracy of T2‐based oximetry. The measured oxygen extraction fraction and cerebral metabolic rate of oxygen of this group of SCA participants were found to not differ significantly from those of healthy individuals. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 139862684 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Quantification of whole‐brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T<subscript>2</subscript>‐based oxygenation calibrations. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Li%2C+Wenbo%22">Li, Wenbo</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> wli47@jhmi.edu</i><br /><searchLink fieldCode="AR" term="%22Xu%2C+Xiang%22">Xu, Xiang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Peiying%22">Liu, Peiying</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Strouse%2C+John+J%2E%22">Strouse, John J.</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Casella%2C+James+F%2E%22">Casella, James F.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Hanzhang%22">Lu, Hanzhang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zijl%2C+Peter+C%2EM%2E%22">Zijl, Peter C.M.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qin%2C+Qin%22">Qin, Qin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Mar2020, Vol. 83 Issue 3, p1066-1080. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Sickle+cell+anemia%22">Sickle cell anemia</searchLink><br /><searchLink fieldCode="DE" term="%22Oxygen+consumption%22">Oxygen consumption</searchLink><br /><searchLink fieldCode="DE" term="%22Calibration%22">Calibration</searchLink><br /><searchLink fieldCode="DE" term="%22Jugular+vein%22">Jugular vein</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sampling%22">Blood sampling</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To evaluate different T2‐oxygenation calibrations for estimating venous oxygenation in people with sickle cell anemia (SCA). Methods: Blood T2 values were measured at 3 T in the internal jugular veins of 12 healthy volunteers and 11 SCA participants with no history of stroke, recent transfusion, or renal impairment. T2‐oxygenation relationships of both sickled and normal blood samples were calibrated individually and compared with values generated from published models. After converting venous T2 values to venous oxygenation, whole‐brain oxygen extraction fraction and cerebral metabolic rate of oxygen were calculated. Results: Sickle blood samples' oxygenation values calculated from our individual calibrations agreed well with measurements using a blood analyzer, whereas previous T2 calibrations based on normal blood samples showed 13%‐19% underestimation. Meanwhile, oxygenation values calculated from previous grouped T2 calibration for sickle blood agreed well with experimental measurement on averaged values, but showed up to 20% variation for several individual samples. Using individual T2 calibrations, the whole‐brain oxygen extraction fraction and cerebral metabolic rate of oxygen of SCA participants were 0.38 ± 0.08 and 172 ± 42 µmol/min/100 g, respectively, which were comparable to those values measured on healthy volunteers. Conclusion: Our results confirm that sickle blood T2 values not only depend on the hematocrit and oxygenation values, but also on other hematological factors. The individual T2 calibrations minimized the effect of heterogeneity of sickle blood between different SCA populations and improved the accuracy of T2‐based oximetry. The measured oxygen extraction fraction and cerebral metabolic rate of oxygen of this group of SCA participants were found to not differ significantly from those of healthy individuals. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.27972 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1066 Subjects: – SubjectFull: Sickle cell anemia Type: general – SubjectFull: Oxygen consumption Type: general – SubjectFull: Calibration Type: general – SubjectFull: Jugular vein Type: general – SubjectFull: Blood sampling Type: general Titles: – TitleFull: Quantification of whole‐brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2‐based oxygenation calibrations. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li, Wenbo – PersonEntity: Name: NameFull: Xu, Xiang – PersonEntity: Name: NameFull: Liu, Peiying – PersonEntity: Name: NameFull: Strouse, John J. – PersonEntity: Name: NameFull: Casella, James F. – PersonEntity: Name: NameFull: Lu, Hanzhang – PersonEntity: Name: NameFull: Zijl, Peter C.M. – PersonEntity: Name: NameFull: Qin, Qin IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 83 – Type: issue Value: 3 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
