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Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics.

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Title: Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics.
Authors: Watras, Adam1 (AUTHOR) a.watras@intibs.pl, Wujczyk, Marta1 (AUTHOR) r.wiglusz@intibs.pl, Roecken, Michael2 (AUTHOR) Michael.Roecken@vetmed.uni-giessen.de, Kucharczyk, Katarzyna3,4 (AUTHOR) kucharczyk.katarzyna@o2.pl, Marycz, Krzysztof3,4,5 (AUTHOR) krzysztof.marycz@upwr.edu.pl, Wiglusz, Rafal J.1 (AUTHOR)
Source: Nanomaterials (2079-4991). Nov2019, Vol. 9 Issue 11, p1597-1597. 1p.
Subjects: Erbium compounds, Pyrophosphates, Erbium, Companion diagnostics, Self-propagating high-temperature synthesis, Fracture healing, Ions, Scanning electron microscopy
Abstract: Diphosphate compounds (KYP2O7) co-doped with Yb3+ and Er3+ ions were obtained by one step urea assisted combustion synthesis. The experimental parameters of synthesis were optimized using an experimental design approach related to co-dopants concentration and heattreatment as well as annealing time. The obtained materials were studied with theinitial requirements showing appropriate morphological (X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM)) and spectroscopic properties (emission, luminescence kinetics). Moreover, the effect of Er3+ and Yb3+ ions doped KYP2O7 on morphology, proliferative and metabolic activity and apoptosis in MC3T3-E1 osteoblast cell line and 4B12osteoclasts cell line was investigated. Furthermore, the expression of the common pro-osteogenic markers in MC3T3-E1 osteoblast as well as osteoclastogenesis related markers in 4B12 osteoclasts was evaluated. The extensive in vitro studies showed that KYP2O7 doped with 1 mol% Er3+ and 20 mol% Yb3+ ions positively affected the MC3T3-E1 and 4B12 cells activity without triggering their apoptosis. Moreover, it was shown that an activation of mTOR and Pi3k signaling pathways with 1 mol% Er3+, 20 mol% Yb3+: KYP2O7 can promote the MC3T3-E1 cells expression of late osteogenic markers including RUNX and BMP-2. The obtained data shed a promising light for KYP2O7 doped with Er3+ and Yb3+ ions as a potential factors improving bone fracture healing as well as in bioimaging (so-called in theranostics). [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics.
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  Data: <searchLink fieldCode="AR" term="%22Watras%2C+Adam%22">Watras, Adam</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> a.watras@intibs.pl</i><br /><searchLink fieldCode="AR" term="%22Wujczyk%2C+Marta%22">Wujczyk, Marta</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> r.wiglusz@intibs.pl</i><br /><searchLink fieldCode="AR" term="%22Roecken%2C+Michael%22">Roecken, Michael</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> Michael.Roecken@vetmed.uni-giessen.de</i><br /><searchLink fieldCode="AR" term="%22Kucharczyk%2C+Katarzyna%22">Kucharczyk, Katarzyna</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<i> kucharczyk.katarzyna@o2.pl</i><br /><searchLink fieldCode="AR" term="%22Marycz%2C+Krzysztof%22">Marycz, Krzysztof</searchLink><relatesTo>3,4,5</relatesTo> (AUTHOR)<i> krzysztof.marycz@upwr.edu.pl</i><br /><searchLink fieldCode="AR" term="%22Wiglusz%2C+Rafal+J%2E%22">Wiglusz, Rafal J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Nov2019, Vol. 9 Issue 11, p1597-1597. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Erbium+compounds%22">Erbium compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Pyrophosphates%22">Pyrophosphates</searchLink><br /><searchLink fieldCode="DE" term="%22Erbium%22">Erbium</searchLink><br /><searchLink fieldCode="DE" term="%22Companion+diagnostics%22">Companion diagnostics</searchLink><br /><searchLink fieldCode="DE" term="%22Self-propagating+high-temperature+synthesis%22">Self-propagating high-temperature synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Fracture+healing%22">Fracture healing</searchLink><br /><searchLink fieldCode="DE" term="%22Ions%22">Ions</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+electron+microscopy%22">Scanning electron microscopy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Diphosphate compounds (KYP2O7) co-doped with Yb3+ and Er3+ ions were obtained by one step urea assisted combustion synthesis. The experimental parameters of synthesis were optimized using an experimental design approach related to co-dopants concentration and heattreatment as well as annealing time. The obtained materials were studied with theinitial requirements showing appropriate morphological (X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM)) and spectroscopic properties (emission, luminescence kinetics). Moreover, the effect of Er3+ and Yb3+ ions doped KYP2O7 on morphology, proliferative and metabolic activity and apoptosis in MC3T3-E1 osteoblast cell line and 4B12osteoclasts cell line was investigated. Furthermore, the expression of the common pro-osteogenic markers in MC3T3-E1 osteoblast as well as osteoclastogenesis related markers in 4B12 osteoclasts was evaluated. The extensive in vitro studies showed that KYP2O7 doped with 1 mol% Er3+ and 20 mol% Yb3+ ions positively affected the MC3T3-E1 and 4B12 cells activity without triggering their apoptosis. Moreover, it was shown that an activation of mTOR and Pi3k signaling pathways with 1 mol% Er3+, 20 mol% Yb3+: KYP2O7 can promote the MC3T3-E1 cells expression of late osteogenic markers including RUNX and BMP-2. The obtained data shed a promising light for KYP2O7 doped with Er3+ and Yb3+ ions as a potential factors improving bone fracture healing as well as in bioimaging (so-called in theranostics). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano9111597
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: 1597
    Subjects:
      – SubjectFull: Erbium compounds
        Type: general
      – SubjectFull: Pyrophosphates
        Type: general
      – SubjectFull: Erbium
        Type: general
      – SubjectFull: Companion diagnostics
        Type: general
      – SubjectFull: Self-propagating high-temperature synthesis
        Type: general
      – SubjectFull: Fracture healing
        Type: general
      – SubjectFull: Ions
        Type: general
      – SubjectFull: Scanning electron microscopy
        Type: general
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      – TitleFull: Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics.
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              M: 11
              Text: Nov2019
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