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The performances of serum activins and follistatin in the diagnosis of ectopic pregnancy: A prospective case-control study.

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Title: The performances of serum activins and follistatin in the diagnosis of ectopic pregnancy: A prospective case-control study.
Authors: Refaat, Bassem1 (AUTHOR) bassem.refaat@yahoo.co.uk, Bahathiq, Adil O.2 (AUTHOR)
Source: Clinica Chimica Acta. Jan2020, Vol. 500, p69-74. 6p.
Subjects: Ectopic pregnancy, Follistatin, Activin, Miscarriage, Longitudinal method, Case-control method
Abstract: • Activins and follistatin are pathologically altered during early pregnancy failure. • Activin-AB & activin-A showed higher performances than β-hCG & progesterone for EP. • Progesterone followed by activin-AB were sensitive and specific for abortion. • Combining activin-AB & progesterone could provide a better diagnostic tool for EP. The diagnosis of ectopic pregnancy (EP) is challenging and 40–50% of patients are initially misdiagnosed. This prospective case-control study measured activin-A, activin-B, activin-AB and follistatin for the diagnosis of EP, spontaneous abortion (SAB) and normal intrauterine pregnancy (IUP). Sera were collected from 120 women with symptoms suggesting early pregnancy failure and who were clinically diagnosed as IUP, SAB or EP (n = 40/group). The markers were measured by ELISA and their area under the curve (AUC), cut-off value, sensitivity and specificity were determined by receiver-operating characteristic curve. The results were compared with serum β-human chorionic gonadotropin and progesterone. Activin-A and activin-B decreased significantly, while activin-AB and follistatin increased, in the EP and SAB groups than the IUP group. Activin-AB (AUC = 0.961) and progesterone (AUC = 0.973) were the best markers for EP and SAB, respectively. Activin-AB (≥61.5 pg/mL) showed 92.5% sensitivity, 85% specificity, 75.5% positive predictive value (PPV) and 95.8% negative predictive value (NPV) for EP. Progesterone (≤6.3 ng/mL) had 100% sensitivity, 86.2% specificity, 78.4% PPV and 100% NPV for SAB. Serum activins and follistatin were significantly altered with EP and activin-AB could be a promising marker for the diagnosis of EP. [ABSTRACT FROM AUTHOR]
Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 141108444
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: The performances of serum activins and follistatin in the diagnosis of ectopic pregnancy: A prospective case-control study.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Refaat%2C+Bassem%22">Refaat, Bassem</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> bassem.refaat@yahoo.co.uk</i><br /><searchLink fieldCode="AR" term="%22Bahathiq%2C+Adil+O%2E%22">Bahathiq, Adil O.</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Clinica+Chimica+Acta%22">Clinica Chimica Acta</searchLink>. Jan2020, Vol. 500, p69-74. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Ectopic+pregnancy%22">Ectopic pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Follistatin%22">Follistatin</searchLink><br /><searchLink fieldCode="DE" term="%22Activin%22">Activin</searchLink><br /><searchLink fieldCode="DE" term="%22Miscarriage%22">Miscarriage</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: • Activins and follistatin are pathologically altered during early pregnancy failure. • Activin-AB & activin-A showed higher performances than β-hCG & progesterone for EP. • Progesterone followed by activin-AB were sensitive and specific for abortion. • Combining activin-AB & progesterone could provide a better diagnostic tool for EP. The diagnosis of ectopic pregnancy (EP) is challenging and 40–50% of patients are initially misdiagnosed. This prospective case-control study measured activin-A, activin-B, activin-AB and follistatin for the diagnosis of EP, spontaneous abortion (SAB) and normal intrauterine pregnancy (IUP). Sera were collected from 120 women with symptoms suggesting early pregnancy failure and who were clinically diagnosed as IUP, SAB or EP (n = 40/group). The markers were measured by ELISA and their area under the curve (AUC), cut-off value, sensitivity and specificity were determined by receiver-operating characteristic curve. The results were compared with serum β-human chorionic gonadotropin and progesterone. Activin-A and activin-B decreased significantly, while activin-AB and follistatin increased, in the EP and SAB groups than the IUP group. Activin-AB (AUC = 0.961) and progesterone (AUC = 0.973) were the best markers for EP and SAB, respectively. Activin-AB (≥61.5 pg/mL) showed 92.5% sensitivity, 85% specificity, 75.5% positive predictive value (PPV) and 95.8% negative predictive value (NPV) for EP. Progesterone (≤6.3 ng/mL) had 100% sensitivity, 86.2% specificity, 78.4% PPV and 100% NPV for SAB. Serum activins and follistatin were significantly altered with EP and activin-AB could be a promising marker for the diagnosis of EP. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.cca.2019.09.019
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 69
    Subjects:
      – SubjectFull: Ectopic pregnancy
        Type: general
      – SubjectFull: Follistatin
        Type: general
      – SubjectFull: Activin
        Type: general
      – SubjectFull: Miscarriage
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Case-control method
        Type: general
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      – TitleFull: The performances of serum activins and follistatin in the diagnosis of ectopic pregnancy: A prospective case-control study.
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            NameFull: Refaat, Bassem
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            NameFull: Bahathiq, Adil O.
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              Text: Jan2020
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              Y: 2020
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