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Click functionalized, tissue‐specific hydrogels for osteochondral tissue engineering.

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Title: Click functionalized, tissue‐specific hydrogels for osteochondral tissue engineering.
Authors: Guo, Jason L.1 (AUTHOR), Li, Ang1 (AUTHOR), Kim, Yu Seon1 (AUTHOR), Xie, Virginia Y.1 (AUTHOR), Smith, Brandon T.1 (AUTHOR), Watson, Emma1 (AUTHOR), Bao, Gang1 (AUTHOR), Mikos, Antonios G.1 (AUTHOR) mikos@rice.edu
Source: Journal of Biomedical Materials Research, Part A. Mar2020, Vol. 108 Issue 3, p684-693. 10p.
Abstract: Osteochondral repair requires the induction of both articular cartilage and subchondral bone development, necessitating the presentation of multiple tissue‐specific cues for these highly distinct tissues. To provide a singular hydrogel system for the repair of either tissue type, we have developed biofunctionalized, mesenchymal stem cell‐laden hydrogels that can present in situ biochemical cues for either chondrogenesis or osteogenesis by simple click modification of a crosslinker, poly(glycolic acid)‐poly(ethylene glycol)‐poly(glycolic acid)‐di(but‐2‐yne‐1,4‐dithiol) (PdBT). After modifying PdBT with either cartilage‐specific biomolecules (N‐cadherin peptide, chondroitin sulfate) or bone‐specific biomolecules (bone marrow homing peptide 1, glycine‐histidine‐lysine peptide), the biofunctionalized, PdBT‐crosslinked hydrogels can selectively promote the desired bone‐ or cartilage‐like matrix synthesis and tissue‐specific gene expression, with effects dependent on both biomolecule selection and concentration. Our findings establish the versatility of this click functionalized hydrogel system as well as its ability to promote in vitro development of osteochondral tissue phenotypes. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biomedical Materials Research, Part A is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: Click functionalized, tissue‐specific hydrogels for osteochondral tissue engineering.
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomedical+Materials+Research%2C+Part+A%22">Journal of Biomedical Materials Research, Part A</searchLink>. Mar2020, Vol. 108 Issue 3, p684-693. 10p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Osteochondral repair requires the induction of both articular cartilage and subchondral bone development, necessitating the presentation of multiple tissue‐specific cues for these highly distinct tissues. To provide a singular hydrogel system for the repair of either tissue type, we have developed biofunctionalized, mesenchymal stem cell‐laden hydrogels that can present in situ biochemical cues for either chondrogenesis or osteogenesis by simple click modification of a crosslinker, poly(glycolic acid)‐poly(ethylene glycol)‐poly(glycolic acid)‐di(but‐2‐yne‐1,4‐dithiol) (PdBT). After modifying PdBT with either cartilage‐specific biomolecules (N‐cadherin peptide, chondroitin sulfate) or bone‐specific biomolecules (bone marrow homing peptide 1, glycine‐histidine‐lysine peptide), the biofunctionalized, PdBT‐crosslinked hydrogels can selectively promote the desired bone‐ or cartilage‐like matrix synthesis and tissue‐specific gene expression, with effects dependent on both biomolecule selection and concentration. Our findings establish the versatility of this click functionalized hydrogel system as well as its ability to promote in vitro development of osteochondral tissue phenotypes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Biomedical Materials Research, Part A is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Mar2020
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