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Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics.

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Title: Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics.
Authors: Burton, Alex1, Obaid, Sofian N.2, Vázquez-Guardado, Abraham3, Schmit, Matthew B.4,5, Stuart, Tucker1, Le Cai1, Zhiyuan Chen2, Kandela, Irawati6, Haney, Chad R.7, Waters, Emily A.7, Haijiang Cai4,8,9, Rogers, John A.3,10,11,12,13,14,15 jrogers@northwestern.edu, Luyao Lu2 luyaolu@gwu.edu, Gutruf, Philipp1,8,9,16 pgutruf@email.arizona.edu
Source: Proceedings of the National Academy of Sciences of the United States of America. 2/11/2020, Vol. 117 Issue 6, p2835-2845. 11p.
Subjects: Photometry, Optical fibers, Household electronics, Power resources
Abstract: Recording cell-specific neuronal activity while monitoring behaviors of freely moving subjects can provide some of the most significant insights into brain function. Current means for monitoring calcium dynamics in genetically targeted populations of neurons rely on delivery of light and recording of fluorescent signals through optical fibers that can reduce subject mobility, induce motion artifacts, and limit experimental paradigms to isolated subjects in open, two-dimensional (2D) spaces. Wireless alternatives eliminate constraints associated with optical fibers, but their use of head stages with batteries adds bulk and weight that can affect behaviors, with limited operational lifetimes. The systems introduced here avoid drawbacks of both types of technologies, by combining highly miniaturized electronics and energy harvesters with injectable photometric modules in a class of fully wireless, battery-free photometer that is fully implantable subdermally to allow for the interrogation of neural dynamics in freely behaving subjects, without limitations set by fiber optic tethers or operational lifetimes constrained by traditional power supplies. The unique capabilities of these systems, their compatibility with magnetic resonant imaging and computed tomography and the ability to manufacture them with techniques in widespread use for consumer electronics, suggest a potential for broad adoption in neuroscience research. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics.
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  Data: <searchLink fieldCode="AR" term="%22Burton%2C+Alex%22">Burton, Alex</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Obaid%2C+Sofian+N%2E%22">Obaid, Sofian N.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Vázquez-Guardado%2C+Abraham%22">Vázquez-Guardado, Abraham</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Schmit%2C+Matthew+B%2E%22">Schmit, Matthew B.</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Stuart%2C+Tucker%22">Stuart, Tucker</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Le+Cai%22">Le Cai</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhiyuan+Chen%22">Zhiyuan Chen</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kandela%2C+Irawati%22">Kandela, Irawati</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Haney%2C+Chad+R%2E%22">Haney, Chad R.</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Waters%2C+Emily+A%2E%22">Waters, Emily A.</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Haijiang+Cai%22">Haijiang Cai</searchLink><relatesTo>4,8,9</relatesTo><br /><searchLink fieldCode="AR" term="%22Rogers%2C+John+A%2E%22">Rogers, John A.</searchLink><relatesTo>3,10,11,12,13,14,15</relatesTo><i> jrogers@northwestern.edu</i><br /><searchLink fieldCode="AR" term="%22Luyao+Lu%22">Luyao Lu</searchLink><relatesTo>2</relatesTo><i> luyaolu@gwu.edu</i><br /><searchLink fieldCode="AR" term="%22Gutruf%2C+Philipp%22">Gutruf, Philipp</searchLink><relatesTo>1,8,9,16</relatesTo><i> pgutruf@email.arizona.edu</i>
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  Data: Recording cell-specific neuronal activity while monitoring behaviors of freely moving subjects can provide some of the most significant insights into brain function. Current means for monitoring calcium dynamics in genetically targeted populations of neurons rely on delivery of light and recording of fluorescent signals through optical fibers that can reduce subject mobility, induce motion artifacts, and limit experimental paradigms to isolated subjects in open, two-dimensional (2D) spaces. Wireless alternatives eliminate constraints associated with optical fibers, but their use of head stages with batteries adds bulk and weight that can affect behaviors, with limited operational lifetimes. The systems introduced here avoid drawbacks of both types of technologies, by combining highly miniaturized electronics and energy harvesters with injectable photometric modules in a class of fully wireless, battery-free photometer that is fully implantable subdermally to allow for the interrogation of neural dynamics in freely behaving subjects, without limitations set by fiber optic tethers or operational lifetimes constrained by traditional power supplies. The unique capabilities of these systems, their compatibility with magnetic resonant imaging and computed tomography and the ability to manufacture them with techniques in widespread use for consumer electronics, suggest a potential for broad adoption in neuroscience research. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1073/pnas.1920073117
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      – SubjectFull: Household electronics
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