View in EDS

NFATc1+CD31+CD45− circulating multipotent stem cells derived from human endocardium and their therapeutic potential.

Saved in:
Bibliographic Details
Title: NFATc1+CD31+CD45− circulating multipotent stem cells derived from human endocardium and their therapeutic potential.
Authors: Yang, Han-Mo1,2,3 (AUTHOR), Kim, Ju-Young1,2,3 (AUTHOR), Cho, Hyun-Jai1,2,3 (AUTHOR), Lee, Joo-Eun2,3 (AUTHOR), Jin, Sooryeonhwa2,3 (AUTHOR), Hur, Jin2,3 (AUTHOR), Kwon, Yoo-Wook2,3 (AUTHOR), Seong, Moon-Woo4 (AUTHOR), Choi, Eue-Keun1,3 (AUTHOR), Lee, Hae-Young1,3 (AUTHOR), Lee, Hyun-Seob5 (AUTHOR), Jeon, Mika2,3 (AUTHOR), Kim, Joonoh2,3 (AUTHOR), Yang, Jaeseok6 (AUTHOR), Oh, Seil1,3 (AUTHOR), Suh, Kyung-Suk7 (AUTHOR), Yoon, Sung-Soo1 (AUTHOR), Kim, Ki-Bong8 (AUTHOR), Oh, Byung-Hee1,3 (AUTHOR), Park, Young-Bae1,3 (AUTHOR)
Source: Biomaterials. Feb2020, Vol. 232, pN.PAG-N.PAG. 1p.
Subjects: Multipotent stem cells, Endocardium, Microsatellite repeats, Heart cells, Progenitor cells, Myocardial infarction, Atrial arrhythmias
Abstract: Many studies have shown the existence of cardiac stem cells in the myocardium and epicardial progenitor cells in the epicardium. However, the characteristics of stem cells in the endocardium has not been fully elucidated. In this study, we investigated the origin of newly identified cells in the blood and their therapeutic potential. The new population of cells, identified from human peripheral blood, was quite different from previously reported stem cells. These newly identified cells, which we named Circulating Multipotent Stem (CiMS) cells, were multipotent, and therefore differentiated into multiple lineages in vitro and in vivo. In order to determine the origin of these cells, we collected peripheral blood from a group of patients who underwent bone marrow, liver, heart, or kidney transplantation. We identified the endocardium as the origin of these cells because the Short Tandem Repeat profile of CiMS cells from the recipient had changed from the recipient's profile to the donor's profile after heart transplantation. CiMS cells significantly increased after stimuli to the endocardium, such as catheter ablation for arrhythmia or acute myocardial infarction. CiMS cells circulate in human peripheral blood and are easily obtainable, suggesting that these cells could be a promising tool for cell therapy. [ABSTRACT FROM AUTHOR]
Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 141778379
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: NFATc1+CD31+CD45− circulating multipotent stem cells derived from human endocardium and their therapeutic potential.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Yang%2C+Han-Mo%22">Yang, Han-Mo</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Ju-Young%22">Kim, Ju-Young</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cho%2C+Hyun-Jai%22">Cho, Hyun-Jai</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Joo-Eun%22">Lee, Joo-Eun</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jin%2C+Sooryeonhwa%22">Jin, Sooryeonhwa</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hur%2C+Jin%22">Hur, Jin</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kwon%2C+Yoo-Wook%22">Kwon, Yoo-Wook</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seong%2C+Moon-Woo%22">Seong, Moon-Woo</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choi%2C+Eue-Keun%22">Choi, Eue-Keun</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Hae-Young%22">Lee, Hae-Young</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Hyun-Seob%22">Lee, Hyun-Seob</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jeon%2C+Mika%22">Jeon, Mika</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Joonoh%22">Kim, Joonoh</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Jaeseok%22">Yang, Jaeseok</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oh%2C+Seil%22">Oh, Seil</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Suh%2C+Kyung-Suk%22">Suh, Kyung-Suk</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yoon%2C+Sung-Soo%22">Yoon, Sung-Soo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Ki-Bong%22">Kim, Ki-Bong</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oh%2C+Byung-Hee%22">Oh, Byung-Hee</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Young-Bae%22">Park, Young-Bae</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Biomaterials%22">Biomaterials</searchLink>. Feb2020, Vol. 232, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Multipotent+stem+cells%22">Multipotent stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Endocardium%22">Endocardium</searchLink><br /><searchLink fieldCode="DE" term="%22Microsatellite+repeats%22">Microsatellite repeats</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+cells%22">Heart cells</searchLink><br /><searchLink fieldCode="DE" term="%22Progenitor+cells%22">Progenitor cells</searchLink><br /><searchLink fieldCode="DE" term="%22Myocardial+infarction%22">Myocardial infarction</searchLink><br /><searchLink fieldCode="DE" term="%22Atrial+arrhythmias%22">Atrial arrhythmias</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Many studies have shown the existence of cardiac stem cells in the myocardium and epicardial progenitor cells in the epicardium. However, the characteristics of stem cells in the endocardium has not been fully elucidated. In this study, we investigated the origin of newly identified cells in the blood and their therapeutic potential. The new population of cells, identified from human peripheral blood, was quite different from previously reported stem cells. These newly identified cells, which we named Circulating Multipotent Stem (CiMS) cells, were multipotent, and therefore differentiated into multiple lineages in vitro and in vivo. In order to determine the origin of these cells, we collected peripheral blood from a group of patients who underwent bone marrow, liver, heart, or kidney transplantation. We identified the endocardium as the origin of these cells because the Short Tandem Repeat profile of CiMS cells from the recipient had changed from the recipient's profile to the donor's profile after heart transplantation. CiMS cells significantly increased after stimuli to the endocardium, such as catheter ablation for arrhythmia or acute myocardial infarction. CiMS cells circulate in human peripheral blood and are easily obtainable, suggesting that these cells could be a promising tool for cell therapy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=141778379
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.biomaterials.2019.119674
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Multipotent stem cells
        Type: general
      – SubjectFull: Endocardium
        Type: general
      – SubjectFull: Microsatellite repeats
        Type: general
      – SubjectFull: Heart cells
        Type: general
      – SubjectFull: Progenitor cells
        Type: general
      – SubjectFull: Myocardial infarction
        Type: general
      – SubjectFull: Atrial arrhythmias
        Type: general
    Titles:
      – TitleFull: NFATc1+CD31+CD45− circulating multipotent stem cells derived from human endocardium and their therapeutic potential.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yang, Han-Mo
      – PersonEntity:
          Name:
            NameFull: Kim, Ju-Young
      – PersonEntity:
          Name:
            NameFull: Cho, Hyun-Jai
      – PersonEntity:
          Name:
            NameFull: Lee, Joo-Eun
      – PersonEntity:
          Name:
            NameFull: Jin, Sooryeonhwa
      – PersonEntity:
          Name:
            NameFull: Hur, Jin
      – PersonEntity:
          Name:
            NameFull: Kwon, Yoo-Wook
      – PersonEntity:
          Name:
            NameFull: Seong, Moon-Woo
      – PersonEntity:
          Name:
            NameFull: Choi, Eue-Keun
      – PersonEntity:
          Name:
            NameFull: Lee, Hae-Young
      – PersonEntity:
          Name:
            NameFull: Lee, Hyun-Seob
      – PersonEntity:
          Name:
            NameFull: Jeon, Mika
      – PersonEntity:
          Name:
            NameFull: Kim, Joonoh
      – PersonEntity:
          Name:
            NameFull: Yang, Jaeseok
      – PersonEntity:
          Name:
            NameFull: Oh, Seil
      – PersonEntity:
          Name:
            NameFull: Suh, Kyung-Suk
      – PersonEntity:
          Name:
            NameFull: Yoon, Sung-Soo
      – PersonEntity:
          Name:
            NameFull: Kim, Ki-Bong
      – PersonEntity:
          Name:
            NameFull: Oh, Byung-Hee
      – PersonEntity:
          Name:
            NameFull: Park, Young-Bae
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 20
              M: 02
              Text: Feb2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 01429612
          Numbering:
            – Type: volume
              Value: 232
          Titles:
            – TitleFull: Biomaterials
              Type: main
ResultId 1