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Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics.

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Title: Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics.
Authors: Zienkiewicz, Jan A.1 (AUTHOR) j.zienkiewicz@intibs.pl, Strzep, Adam1 (AUTHOR) a.strzep@intibs.pl, Jedrzkiewicz, Dawid2 (AUTHOR) dawid.jedrzkiewicz@chem.uni.wroc.pl, Nowak, Nicole1 (AUTHOR) n.nowak@intibs.pl, Rewak-Soroczynska, Justyna1 (AUTHOR) j.rewak@intibs.pl, Watras, Adam1 (AUTHOR) a.watras@intibs.pl, Ejfler, Jolanta2 (AUTHOR) jolanta.ejfler@chem.uni.wroc.pl, Wiglusz, Rafal J.1,3 (AUTHOR) r.wiglusz@intibs.pl
Source: Nanomaterials (2079-4991). Feb2020, Vol. 10 Issue 2, p331. 1p.
Subjects: Bones, Luminescence spectroscopy, Companion diagnostics, Emission spectroscopy, Scanning electron microscopy
Abstract: This work was aimed to obtain and characterize the well-defined biocomposites based on β-tricalcium diphosphate(V) (β-TCP) co-doped with Ce3+ and Pr3+ ions modified by poly(l-lactide) (PLLA) with precise tailored chain length and different phosphate to polymer ratio. The composites as well as β-tricalcium diphosphate(V) were spectroscopically characterized using emission spectroscopy and luminescence kinetics. Morphological and structural properties were studied using X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). The self-assembled poly(l-lactide) in a shape of rose flower has been successfully polymerized on the surface of the β-tricalcium diphosphate(V) nanocrystals. The studied materials were evaluated in vitro including cytotoxicity (MTT assay) and hemolysis tests. The obtained results suggested that the studied materials may find potential application in tissue engineering. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics.
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  Data: <searchLink fieldCode="AR" term="%22Zienkiewicz%2C+Jan+A%2E%22">Zienkiewicz, Jan A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> j.zienkiewicz@intibs.pl</i><br /><searchLink fieldCode="AR" term="%22Strzep%2C+Adam%22">Strzep, Adam</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> a.strzep@intibs.pl</i><br /><searchLink fieldCode="AR" term="%22Jedrzkiewicz%2C+Dawid%22">Jedrzkiewicz, Dawid</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> dawid.jedrzkiewicz@chem.uni.wroc.pl</i><br /><searchLink fieldCode="AR" term="%22Nowak%2C+Nicole%22">Nowak, Nicole</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> n.nowak@intibs.pl</i><br /><searchLink fieldCode="AR" term="%22Rewak-Soroczynska%2C+Justyna%22">Rewak-Soroczynska, Justyna</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> j.rewak@intibs.pl</i><br /><searchLink fieldCode="AR" term="%22Watras%2C+Adam%22">Watras, Adam</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> a.watras@intibs.pl</i><br /><searchLink fieldCode="AR" term="%22Ejfler%2C+Jolanta%22">Ejfler, Jolanta</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> jolanta.ejfler@chem.uni.wroc.pl</i><br /><searchLink fieldCode="AR" term="%22Wiglusz%2C+Rafal+J%2E%22">Wiglusz, Rafal J.</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> r.wiglusz@intibs.pl</i>
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  Data: <searchLink fieldCode="DE" term="%22Bones%22">Bones</searchLink><br /><searchLink fieldCode="DE" term="%22Luminescence+spectroscopy%22">Luminescence spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Companion+diagnostics%22">Companion diagnostics</searchLink><br /><searchLink fieldCode="DE" term="%22Emission+spectroscopy%22">Emission spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+electron+microscopy%22">Scanning electron microscopy</searchLink>
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  Data: This work was aimed to obtain and characterize the well-defined biocomposites based on β-tricalcium diphosphate(V) (β-TCP) co-doped with Ce3+ and Pr3+ ions modified by poly(l-lactide) (PLLA) with precise tailored chain length and different phosphate to polymer ratio. The composites as well as β-tricalcium diphosphate(V) were spectroscopically characterized using emission spectroscopy and luminescence kinetics. Morphological and structural properties were studied using X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). The self-assembled poly(l-lactide) in a shape of rose flower has been successfully polymerized on the surface of the β-tricalcium diphosphate(V) nanocrystals. The studied materials were evaluated in vitro including cytotoxicity (MTT assay) and hemolysis tests. The obtained results suggested that the studied materials may find potential application in tissue engineering. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano10020331
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        Text: English
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      – SubjectFull: Bones
        Type: general
      – SubjectFull: Luminescence spectroscopy
        Type: general
      – SubjectFull: Companion diagnostics
        Type: general
      – SubjectFull: Emission spectroscopy
        Type: general
      – SubjectFull: Scanning electron microscopy
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      – TitleFull: Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics.
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              M: 02
              Text: Feb2020
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