View in EDS

Virtual spectral histopathology of colon cancer - biomedical applications of Raman spectroscopy and imaging.

Saved in:
Bibliographic Details
Title: Virtual spectral histopathology of colon cancer - biomedical applications of Raman spectroscopy and imaging.
Authors: Brozek-Pluska, Beata1 (AUTHOR) beata.brozek-pluska@p.lodz.pl, Dziki, Adam2 (AUTHOR), Abramczyk, Halina1 (AUTHOR)
Source: Journal of Molecular Liquids. Apr2020, Vol. 303, pN.PAG-N.PAG. 1p.
Subjects: Colon cancer, Cancer histopathology, Sigmoid colon, Protein conformation, Colon (Anatomy), Molecular spectroscopy, Raman spectroscopy
Geographic Terms: Poland
Abstract: Colon cancer is one of the most commonly detected pathology and is the third worldwide cause of death in the US and Europe and ranks second with regard to the incidence of malignant tumors in population. Raman spectroscopy and imaging can be used for colon cancer detection and bioanalytical characterization of noncancerous and pathologically changed tissues. These studies included Raman spectroscopy measurement of not fixed and not stained tissues samples. Presented study included patients from Poland, who were ≥18 years of age and underwent colon cancer surgery. Outcomes were measured using confocal Raman microscope, spectroscopy results were compared with traditional histopathology analysis outcomes. DNA, lipids, proteins and carotenoids can be treated as biomarkers of cancerogenesis. Ratios: 751/1156 (DNA/Carotenoids), 1228/1332 (β-sheet/α-helix proteins conformation), 1586/1004 (Phosphorylated proteins/Proteins), 2854/2935 (Lipids/Proteins) can be used to differentiate noncancerous and cancerous human sigmoid colon mucosa based on Raman spectroscopy and imaging. We have proved that Raman spectroscopy and imaging are a powerful technique to distinguish between noncancerous and cancerous human sigmoid colon mucosa and to characterize biochemical composition of multilayer sigmoid colon tissues samples. • Colon cancer changes can be detected by Raman spectroscopy and imaging. • DNA, lipids, proteins and carotenoids are treated as biomarkers of carcinogenesis. • Different biomarkers can be simultaneously analyzed by Raman spectroscopy. • Human colon tissues can be characterized without external staining. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Molecular Liquids is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 142250444
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Virtual spectral histopathology of colon cancer - biomedical applications of Raman spectroscopy and imaging.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Brozek-Pluska%2C+Beata%22">Brozek-Pluska, Beata</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> beata.brozek-pluska@p.lodz.pl</i><br /><searchLink fieldCode="AR" term="%22Dziki%2C+Adam%22">Dziki, Adam</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abramczyk%2C+Halina%22">Abramczyk, Halina</searchLink><relatesTo>1</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Molecular+Liquids%22">Journal of Molecular Liquids</searchLink>. Apr2020, Vol. 303, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Colon+cancer%22">Colon cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+histopathology%22">Cancer histopathology</searchLink><br /><searchLink fieldCode="DE" term="%22Sigmoid+colon%22">Sigmoid colon</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+conformation%22">Protein conformation</searchLink><br /><searchLink fieldCode="DE" term="%22Colon+%28Anatomy%29%22">Colon (Anatomy)</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+spectroscopy%22">Molecular spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Raman+spectroscopy%22">Raman spectroscopy</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Poland%22">Poland</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Colon cancer is one of the most commonly detected pathology and is the third worldwide cause of death in the US and Europe and ranks second with regard to the incidence of malignant tumors in population. Raman spectroscopy and imaging can be used for colon cancer detection and bioanalytical characterization of noncancerous and pathologically changed tissues. These studies included Raman spectroscopy measurement of not fixed and not stained tissues samples. Presented study included patients from Poland, who were ≥18 years of age and underwent colon cancer surgery. Outcomes were measured using confocal Raman microscope, spectroscopy results were compared with traditional histopathology analysis outcomes. DNA, lipids, proteins and carotenoids can be treated as biomarkers of cancerogenesis. Ratios: 751/1156 (DNA/Carotenoids), 1228/1332 (β-sheet/α-helix proteins conformation), 1586/1004 (Phosphorylated proteins/Proteins), 2854/2935 (Lipids/Proteins) can be used to differentiate noncancerous and cancerous human sigmoid colon mucosa based on Raman spectroscopy and imaging. We have proved that Raman spectroscopy and imaging are a powerful technique to distinguish between noncancerous and cancerous human sigmoid colon mucosa and to characterize biochemical composition of multilayer sigmoid colon tissues samples. • Colon cancer changes can be detected by Raman spectroscopy and imaging. • DNA, lipids, proteins and carotenoids are treated as biomarkers of carcinogenesis. • Different biomarkers can be simultaneously analyzed by Raman spectroscopy. • Human colon tissues can be characterized without external staining. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Molecular Liquids is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=142250444
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.molliq.2020.112676
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Colon cancer
        Type: general
      – SubjectFull: Cancer histopathology
        Type: general
      – SubjectFull: Sigmoid colon
        Type: general
      – SubjectFull: Protein conformation
        Type: general
      – SubjectFull: Colon (Anatomy)
        Type: general
      – SubjectFull: Molecular spectroscopy
        Type: general
      – SubjectFull: Raman spectroscopy
        Type: general
      – SubjectFull: Poland
        Type: general
    Titles:
      – TitleFull: Virtual spectral histopathology of colon cancer - biomedical applications of Raman spectroscopy and imaging.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Brozek-Pluska, Beata
      – PersonEntity:
          Name:
            NameFull: Dziki, Adam
      – PersonEntity:
          Name:
            NameFull: Abramczyk, Halina
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 01677322
          Numbering:
            – Type: volume
              Value: 303
          Titles:
            – TitleFull: Journal of Molecular Liquids
              Type: main
ResultId 1