Polycaprolactone vascular graft with epigallocatechin gallate embedded sandwiched layer-by-layer functionalization for enhanced antithrombogenicity and anti-inflammation.
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| Title: | Polycaprolactone vascular graft with epigallocatechin gallate embedded sandwiched layer-by-layer functionalization for enhanced antithrombogenicity and anti-inflammation. |
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| Authors: | Wang, Yanan1 (AUTHOR), Ma, Boxuan1 (AUTHOR), Yin, Anlin1 (AUTHOR), Zhang, Bo1 (AUTHOR), Luo, Rifang1 (AUTHOR) lrifang@scu.edu.cn, Pan, Junqiang1,2 (AUTHOR) pjq1980214@163.com, Wang, Yunbing1 (AUTHOR) yunbing.wang@scu.edu.cn |
| Source: | Journal of Controlled Release. Apr2020, Vol. 320, p226-238. 13p. |
| Subjects: | Vascular grafts, Epigallocatechin gallate, Polycaprolactone, Surface chemistry, Polyethyleneimine, Intermolecular interactions, Macrophage activation |
| Abstract: | Small-diameter artificial vascular grafts modified with layer-by-layer (LBL) coating show promise in reducing the failure caused by thrombosis and inflammation, but undesirable stability and bioactivity issues of the coating and payload usually limits their long-term efficacy. Herein, inspired by catechol/gallol surface chemistry, a sandwiched layer-by-layer coating constructed by polyethyleneimine (PEI) and heparin with the embedding of epigallocatechin gallate (EGCG)-dexamethasone combination was used to modify the electrospun polycaprolactone (PCL) vascular grafts. Polyphenol embedding endowed the coating with abundant intermolecular interactions between each coating components, mainly contributed by the π-π stacking, weak intermolecular cross-linking and enriched hydrogen bonding, which further enhanced the coating stability and also supported the sustained release of the payloads, like polyelectrolytes and drugs. Compared with the conventional LBL coating, the loading amounts of heparin and dexamethasone in the EGCG embedded LBL coatings doubled and the drug release could be significantly prolonged without serious initial burst. The in vitro and ex vivo assays indicated that the modified PCL vascular grafts would address impressive prolonged anti-platelet adhesion/activation and anti-fibrinogen denaturation ability. Meanwhile, the dexamethasone loading entrusted the sandwiched LBL coating with mild tissue response, in terms of inhibiting the macrophage activation. These results strongly demonstrated that the sandwiched LBL coating with EGCG embedding was an effective method to improve the patency rates of PCL small artificial vascular grafts, which could also be extended to other blood-contacting materials. Unlabelled Image • Sandwiched LBL coating was sequentially assembled by PEI, EGCG-DEX and heparin. • EGCG enriched intermolecular interactions to enhance the coating stability. • Sandwiched LBL coating performed sustained payloads release behavior. • Modified vascular grafts with anti-inflammation and prolonged anticoagulant. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 142518819 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Polycaprolactone vascular graft with epigallocatechin gallate embedded sandwiched layer-by-layer functionalization for enhanced antithrombogenicity and anti-inflammation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Yanan%22">Wang, Yanan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Boxuan%22">Ma, Boxuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yin%2C+Anlin%22">Yin, Anlin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Bo%22">Zhang, Bo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luo%2C+Rifang%22">Luo, Rifang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lrifang@scu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Pan%2C+Junqiang%22">Pan, Junqiang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> pjq1980214@163.com</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Yunbing%22">Wang, Yunbing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yunbing.wang@scu.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Apr2020, Vol. 320, p226-238. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Vascular+grafts%22">Vascular grafts</searchLink><br /><searchLink fieldCode="DE" term="%22Epigallocatechin+gallate%22">Epigallocatechin gallate</searchLink><br /><searchLink fieldCode="DE" term="%22Polycaprolactone%22">Polycaprolactone</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+chemistry%22">Surface chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethyleneimine%22">Polyethyleneimine</searchLink><br /><searchLink fieldCode="DE" term="%22Intermolecular+interactions%22">Intermolecular interactions</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophage+activation%22">Macrophage activation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Small-diameter artificial vascular grafts modified with layer-by-layer (LBL) coating show promise in reducing the failure caused by thrombosis and inflammation, but undesirable stability and bioactivity issues of the coating and payload usually limits their long-term efficacy. Herein, inspired by catechol/gallol surface chemistry, a sandwiched layer-by-layer coating constructed by polyethyleneimine (PEI) and heparin with the embedding of epigallocatechin gallate (EGCG)-dexamethasone combination was used to modify the electrospun polycaprolactone (PCL) vascular grafts. Polyphenol embedding endowed the coating with abundant intermolecular interactions between each coating components, mainly contributed by the π-π stacking, weak intermolecular cross-linking and enriched hydrogen bonding, which further enhanced the coating stability and also supported the sustained release of the payloads, like polyelectrolytes and drugs. Compared with the conventional LBL coating, the loading amounts of heparin and dexamethasone in the EGCG embedded LBL coatings doubled and the drug release could be significantly prolonged without serious initial burst. The in vitro and ex vivo assays indicated that the modified PCL vascular grafts would address impressive prolonged anti-platelet adhesion/activation and anti-fibrinogen denaturation ability. Meanwhile, the dexamethasone loading entrusted the sandwiched LBL coating with mild tissue response, in terms of inhibiting the macrophage activation. These results strongly demonstrated that the sandwiched LBL coating with EGCG embedding was an effective method to improve the patency rates of PCL small artificial vascular grafts, which could also be extended to other blood-contacting materials. Unlabelled Image • Sandwiched LBL coating was sequentially assembled by PEI, EGCG-DEX and heparin. • EGCG enriched intermolecular interactions to enhance the coating stability. • Sandwiched LBL coating performed sustained payloads release behavior. • Modified vascular grafts with anti-inflammation and prolonged anticoagulant. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jconrel.2020.01.043 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 226 Subjects: – SubjectFull: Vascular grafts Type: general – SubjectFull: Epigallocatechin gallate Type: general – SubjectFull: Polycaprolactone Type: general – SubjectFull: Surface chemistry Type: general – SubjectFull: Polyethyleneimine Type: general – SubjectFull: Intermolecular interactions Type: general – SubjectFull: Macrophage activation Type: general Titles: – TitleFull: Polycaprolactone vascular graft with epigallocatechin gallate embedded sandwiched layer-by-layer functionalization for enhanced antithrombogenicity and anti-inflammation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Yanan – PersonEntity: Name: NameFull: Ma, Boxuan – PersonEntity: Name: NameFull: Yin, Anlin – PersonEntity: Name: NameFull: Zhang, Bo – PersonEntity: Name: NameFull: Luo, Rifang – PersonEntity: Name: NameFull: Pan, Junqiang – PersonEntity: Name: NameFull: Wang, Yunbing IsPartOfRelationships: – BibEntity: Dates: – D: 10 M: 04 Text: Apr2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 01683659 Numbering: – Type: volume Value: 320 Titles: – TitleFull: Journal of Controlled Release Type: main |
| ResultId | 1 |
