Ameliorating effect of glutathione‐enriched herbal formulation (glothione) on alloxan‐induced experimental diabetic model by modulating oxidative stress and pathogenesis.
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| Title: | Ameliorating effect of glutathione‐enriched herbal formulation (glothione) on alloxan‐induced experimental diabetic model by modulating oxidative stress and pathogenesis. |
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| Authors: | Sreevallabhan, Sheethal1 (AUTHOR), Mohanan, Ratheesh1 (AUTHOR) sivatheertha@gmail.com, Sukumaran, Sandya2 (AUTHOR), Sobha, Anumol Parayil1 (AUTHOR), Jose, Svenia Periyappurathu1 (AUTHOR), Sukumarapillai, Asha1 (AUTHOR), Jagmag, Tariq3 (AUTHOR), Tilwani, Jayesh3 (AUTHOR) |
| Source: | Journal of Food Biochemistry. Apr2020, Vol. 44 Issue 4, p1-9. 9p. |
| Subjects: | Oxidative stress, Pancreatic beta cells, Oxidant status, Food habits, Physiological stress, Streptozotocin, Glutathione, Hepatotoxicology |
| Abstract: | Diabetes Mellitus is a common metabolic or endocrine disorder that occurs as a result of insufficient amounts of insulin secretion or defect in the action of insulin produced from pancreatic beta cells. Antioxidant containing food items are very effective in reducing complications that arise due to diabetes, indicating that it may be beneficial for treating metabolic disorders. In this study, we used some essential nutrients enriched with glutathione, named as Glothione (GN), and evaluated the antidiabetic effect of GN in alloxan‐induced diabetic rats. The treatment with GN showed significant reduction in the blood glucose level, HbA1c level, and liver markers like SGOT, SGPT, and ALP and shows increased antioxidant status and decreased inflammatory markers. Histopathological analysis of pancreas and liver tissue showed that there were no abnormalities in the rat after the administration of GN. Thus, antioxidant‐enriched formulation of GN can be used as a potent hypoglycaemic drug. Practical applications: Glothione is a glutathione‐enriched formulation that contains essential nutrients required for the normal functioning of the body. Recent trends in lifestyle and food habits have been noted to cause health risks and subject the body through physical and physiological stress––hence the importance of antioxidant‐rich foods. Antioxidants are capable of boosting metabolism and other physiological processes. Thus, the consumption of GN can enhance the antioxidant status within the body. GN does not contain any chemical ingredients so it will not cause any side effects. It has a strong antidiabetic effect and is also able to control a number of diseases. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 142620670 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Ameliorating effect of glutathione‐enriched herbal formulation (glothione) on alloxan‐induced experimental diabetic model by modulating oxidative stress and pathogenesis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sreevallabhan%2C+Sheethal%22">Sreevallabhan, Sheethal</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mohanan%2C+Ratheesh%22">Mohanan, Ratheesh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> sivatheertha@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Sukumaran%2C+Sandya%22">Sukumaran, Sandya</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sobha%2C+Anumol+Parayil%22">Sobha, Anumol Parayil</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jose%2C+Svenia+Periyappurathu%22">Jose, Svenia Periyappurathu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sukumarapillai%2C+Asha%22">Sukumarapillai, Asha</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jagmag%2C+Tariq%22">Jagmag, Tariq</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tilwani%2C+Jayesh%22">Tilwani, Jayesh</searchLink><relatesTo>3</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. Apr2020, Vol. 44 Issue 4, p1-9. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreatic+beta+cells%22">Pancreatic beta cells</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidant+status%22">Oxidant status</searchLink><br /><searchLink fieldCode="DE" term="%22Food+habits%22">Food habits</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+stress%22">Physiological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Streptozotocin%22">Streptozotocin</searchLink><br /><searchLink fieldCode="DE" term="%22Glutathione%22">Glutathione</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatotoxicology%22">Hepatotoxicology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Diabetes Mellitus is a common metabolic or endocrine disorder that occurs as a result of insufficient amounts of insulin secretion or defect in the action of insulin produced from pancreatic beta cells. Antioxidant containing food items are very effective in reducing complications that arise due to diabetes, indicating that it may be beneficial for treating metabolic disorders. In this study, we used some essential nutrients enriched with glutathione, named as Glothione (GN), and evaluated the antidiabetic effect of GN in alloxan‐induced diabetic rats. The treatment with GN showed significant reduction in the blood glucose level, HbA1c level, and liver markers like SGOT, SGPT, and ALP and shows increased antioxidant status and decreased inflammatory markers. Histopathological analysis of pancreas and liver tissue showed that there were no abnormalities in the rat after the administration of GN. Thus, antioxidant‐enriched formulation of GN can be used as a potent hypoglycaemic drug. Practical applications: Glothione is a glutathione‐enriched formulation that contains essential nutrients required for the normal functioning of the body. Recent trends in lifestyle and food habits have been noted to cause health risks and subject the body through physical and physiological stress––hence the importance of antioxidant‐rich foods. Antioxidants are capable of boosting metabolism and other physiological processes. Thus, the consumption of GN can enhance the antioxidant status within the body. GN does not contain any chemical ingredients so it will not cause any side effects. It has a strong antidiabetic effect and is also able to control a number of diseases. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/jfbc.13153 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1 Subjects: – SubjectFull: Oxidative stress Type: general – SubjectFull: Pancreatic beta cells Type: general – SubjectFull: Oxidant status Type: general – SubjectFull: Food habits Type: general – SubjectFull: Physiological stress Type: general – SubjectFull: Streptozotocin Type: general – SubjectFull: Glutathione Type: general – SubjectFull: Hepatotoxicology Type: general Titles: – TitleFull: Ameliorating effect of glutathione‐enriched herbal formulation (glothione) on alloxan‐induced experimental diabetic model by modulating oxidative stress and pathogenesis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sreevallabhan, Sheethal – PersonEntity: Name: NameFull: Mohanan, Ratheesh – PersonEntity: Name: NameFull: Sukumaran, Sandya – PersonEntity: Name: NameFull: Sobha, Anumol Parayil – PersonEntity: Name: NameFull: Jose, Svenia Periyappurathu – PersonEntity: Name: NameFull: Sukumarapillai, Asha – PersonEntity: Name: NameFull: Jagmag, Tariq – PersonEntity: Name: NameFull: Tilwani, Jayesh IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 01458884 Numbering: – Type: volume Value: 44 – Type: issue Value: 4 Titles: – TitleFull: Journal of Food Biochemistry Type: main |
| ResultId | 1 |
