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Quantitative evaluation of lung injury caused by PM2.5 using hyperpolarized gas magnetic resonance.

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Title: Quantitative evaluation of lung injury caused by PM2.5 using hyperpolarized gas magnetic resonance.
Authors: Zhang, Ming1 (AUTHOR), Li, Haidong1,2 (AUTHOR), Li, Hongchuang1,2 (AUTHOR), Zhao, Xiuchao1,2 (AUTHOR), Zhou, Qian1,2 (AUTHOR), Rao, Qiuchen1 (AUTHOR), Han, Yeqing1,2 (AUTHOR), Lan, Yina3 (AUTHOR), Deng, He1,2 (AUTHOR), Sun, Xianping1,2 (AUTHOR), Lou, Xin3 (AUTHOR), Ye, Chaohui1,2 (AUTHOR), Zhou, Xin1,2 (AUTHOR) xinzhou@wipm.ac.cn
Source: Magnetic Resonance in Medicine. Aug2020, Vol. 84 Issue 2, p569-578. 10p.
Subjects: Magnetic resonance, Lung injuries, Pulmonary function tests, Diffusion magnetic resonance imaging, Air pollution
Abstract: Purpose: To demonstrate the feasibility of 129Xe MR in evaluating the pulmonary physiological changes caused by PM2.5 in animal models. Methods: Six rats were treated with PM2.5 solution (16.2 mg/kg) by intratracheal instillation twice a week for 4 weeks, and another six rats treated with normal saline served as the control cohort. Pulmonary function tests, hyperpolarized 129Xe multi‐b diffusion‐weighted imaging, and chemical shift saturation recovery MR spectroscopy were performed on all rats, and the pulmonary structure and functional parameters were obtained from hyperpolarized 129Xe MR data. Additionally, histological analysis was performed on all rats to evaluate alveolar septal thickness. Statistical analysis of all the obtained parameters was performed using unpaired 2‐tailed t tests. Results: Compared with the control group, the measured exchange time constant increased from 11.74 ± 2.39 to 14.00 ± 2.84 ms (P <.05), and the septal wall thickness increased from 6.17 ± 0.48 to 6.74 ± 0.52 μm (P <.05) in the PM2.5 cohort by 129Xe MR spectroscopy, which correlated well with that obtained using quantitative histology (increased from 5.52 ± 0.32 to 6.20 ± 0.36 μm). Additionally, the mean TP/GAS ratio increased from 0.828 ± 0.115 to 1.019 ± 0.140 in the PM2.5 cohort (P =.021). Conclusions: Hyperpolarized 129Xe MR could quantify the changes in gas exchange physiology caused by PM2.5, indicating that the technique has the potential to be a useful tool for evaluation of pulmonary injury caused by air pollution in the future. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Quantitative evaluation of lung injury caused by PM&lt;subscript&gt;2.5&lt;/subscript&gt; using hyperpolarized gas magnetic resonance.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Ming%22&quot;&gt;Zhang, Ming&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Haidong%22&quot;&gt;Li, Haidong&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Hongchuang%22&quot;&gt;Li, Hongchuang&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhao%2C+Xiuchao%22&quot;&gt;Zhao, Xiuchao&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhou%2C+Qian%22&quot;&gt;Zhou, Qian&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rao%2C+Qiuchen%22&quot;&gt;Rao, Qiuchen&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Han%2C+Yeqing%22&quot;&gt;Han, Yeqing&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lan%2C+Yina%22&quot;&gt;Lan, Yina&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Deng%2C+He%22&quot;&gt;Deng, He&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sun%2C+Xianping%22&quot;&gt;Sun, Xianping&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lou%2C+Xin%22&quot;&gt;Lou, Xin&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ye%2C+Chaohui%22&quot;&gt;Ye, Chaohui&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhou%2C+Xin%22&quot;&gt;Zhou, Xin&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; xinzhou@wipm.ac.cn&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Magnetic+Resonance+in+Medicine%22&quot;&gt;Magnetic Resonance in Medicine&lt;/searchLink&gt;. Aug2020, Vol. 84 Issue 2, p569-578. 10p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetic+resonance%22&quot;&gt;Magnetic resonance&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Lung+injuries%22&quot;&gt;Lung injuries&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pulmonary+function+tests%22&quot;&gt;Pulmonary function tests&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Diffusion+magnetic+resonance+imaging%22&quot;&gt;Diffusion magnetic resonance imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Air+pollution%22&quot;&gt;Air pollution&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To demonstrate the feasibility of 129Xe MR in evaluating the pulmonary physiological changes caused by PM2.5 in animal models. Methods: Six rats were treated with PM2.5 solution (16.2 mg/kg) by intratracheal instillation twice a week for 4 weeks, and another six rats treated with normal saline served as the control cohort. Pulmonary function tests, hyperpolarized 129Xe multi‐b diffusion‐weighted imaging, and chemical shift saturation recovery MR spectroscopy were performed on all rats, and the pulmonary structure and functional parameters were obtained from hyperpolarized 129Xe MR data. Additionally, histological analysis was performed on all rats to evaluate alveolar septal thickness. Statistical analysis of all the obtained parameters was performed using unpaired 2‐tailed t tests. Results: Compared with the control group, the measured exchange time constant increased from 11.74 &#177; 2.39 to 14.00 &#177; 2.84 ms (P &lt;.05), and the septal wall thickness increased from 6.17 &#177; 0.48 to 6.74 &#177; 0.52 μm (P &lt;.05) in the PM2.5 cohort by 129Xe MR spectroscopy, which correlated well with that obtained using quantitative histology (increased from 5.52 &#177; 0.32 to 6.20 &#177; 0.36 μm). Additionally, the mean TP/GAS ratio increased from 0.828 &#177; 0.115 to 1.019 &#177; 0.140 in the PM2.5 cohort (P =.021). Conclusions: Hyperpolarized 129Xe MR could quantify the changes in gas exchange physiology caused by PM2.5, indicating that the technique has the potential to be a useful tool for evaluation of pulmonary injury caused by air pollution in the future. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.28145
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        Text: English
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      – SubjectFull: Lung injuries
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              Text: Aug2020
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