View in EDS PDF Full Text

Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]‐layered double hydroxide as an antimicrobial wound dressing.

Saved in:
Bibliographic Details
Title: Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]‐layered double hydroxide as an antimicrobial wound dressing.
Authors: Malafatti, João O. D.1,2 (AUTHOR), Bernardo, Marcela P.1 (AUTHOR), Moreira, Francys K. V.3 (AUTHOR), Ciol, Heloisa4 (AUTHOR), Inada, Natalia M.4 (AUTHOR), Mattoso, Luiz H.C.1 (AUTHOR), Paris, Elaine C.1 (AUTHOR) elaine.paris@embrapa.br
Source: Polymers for Advanced Technologies. Jun2020, Vol. 31 Issue 6, p1377-1387. 11p.
Subjects: Antimicrobial bandages, Lactic acid, Hydroxides, Nanofibers, Silver sulfadiazine, Magnesium ions, Scanning electron microscopy
Abstract: Poly(lactic acid) (PLA) is a versatile, bioabsorbable, and biodegradable polymer with excellent biocompatibility and ability to incorporate a great variety of active agents. Silver sulfadiazine (SDZ) is an antibiotic used to control bacterial infection in external wounds. Aiming to combine the properties of PLA and SDZ, hydrotalcite ([Mg–Al]‐LDH) was used as a host matrix to obtain an antimicrobial system efficient in delivering SDZ from electrospun PLA scaffolds intended for wound skin healing. The structural reconstruction method was successfully applied to intercalate silver sulfadiazine in the [Mg–Al]‐LDH, as evidenced by X‐ray diffraction and thermogravimetric analyses. Observations by scanning electron microscopy revealed a good distribution of SDZ‐[Mg–Al]‐LDH within the PLA scaffold. Kinetics studies revealed a slow release of SDZ from the PLA scaffold due to the intercalation in the [Mg–Al]‐LDH. In vitro antimicrobial tests indicated a significant inhibitory effect of SDZ‐[Mg–Al]‐LDH against Escherichia coli and Staphylococcus aureus. This antibacterial activity was sustained in the 2.5‐wt% SDZ‐[Mg–Al]‐LDH–loaded PLA nanofibers, which also displayed excellent biocompatibility towards human cells. The multifunctionality of the PLA/SDZ‐[Mg–Al]‐LDH scaffold reported here is of great significance for various transdermal applications. [ABSTRACT FROM AUTHOR]
Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 142972578
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]‐layered double hydroxide as an antimicrobial wound dressing.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Malafatti%2C+João+O%2E+D%2E%22">Malafatti, João O. D.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bernardo%2C+Marcela+P%2E%22">Bernardo, Marcela P.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moreira%2C+Francys+K%2E+V%2E%22">Moreira, Francys K. V.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ciol%2C+Heloisa%22">Ciol, Heloisa</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Inada%2C+Natalia+M%2E%22">Inada, Natalia M.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mattoso%2C+Luiz+H%2EC%2E%22">Mattoso, Luiz H.C.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paris%2C+Elaine+C%2E%22">Paris, Elaine C.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> elaine.paris@embrapa.br</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Polymers+for+Advanced+Technologies%22">Polymers for Advanced Technologies</searchLink>. Jun2020, Vol. 31 Issue 6, p1377-1387. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Antimicrobial+bandages%22">Antimicrobial bandages</searchLink><br /><searchLink fieldCode="DE" term="%22Lactic+acid%22">Lactic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxides%22">Hydroxides</searchLink><br /><searchLink fieldCode="DE" term="%22Nanofibers%22">Nanofibers</searchLink><br /><searchLink fieldCode="DE" term="%22Silver+sulfadiazine%22">Silver sulfadiazine</searchLink><br /><searchLink fieldCode="DE" term="%22Magnesium+ions%22">Magnesium ions</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+electron+microscopy%22">Scanning electron microscopy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Poly(lactic acid) (PLA) is a versatile, bioabsorbable, and biodegradable polymer with excellent biocompatibility and ability to incorporate a great variety of active agents. Silver sulfadiazine (SDZ) is an antibiotic used to control bacterial infection in external wounds. Aiming to combine the properties of PLA and SDZ, hydrotalcite ([Mg–Al]‐LDH) was used as a host matrix to obtain an antimicrobial system efficient in delivering SDZ from electrospun PLA scaffolds intended for wound skin healing. The structural reconstruction method was successfully applied to intercalate silver sulfadiazine in the [Mg–Al]‐LDH, as evidenced by X‐ray diffraction and thermogravimetric analyses. Observations by scanning electron microscopy revealed a good distribution of SDZ‐[Mg–Al]‐LDH within the PLA scaffold. Kinetics studies revealed a slow release of SDZ from the PLA scaffold due to the intercalation in the [Mg–Al]‐LDH. In vitro antimicrobial tests indicated a significant inhibitory effect of SDZ‐[Mg–Al]‐LDH against Escherichia coli and Staphylococcus aureus. This antibacterial activity was sustained in the 2.5‐wt% SDZ‐[Mg–Al]‐LDH–loaded PLA nanofibers, which also displayed excellent biocompatibility towards human cells. The multifunctionality of the PLA/SDZ‐[Mg–Al]‐LDH scaffold reported here is of great significance for various transdermal applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=142972578
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/pat.4867
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 1377
    Subjects:
      – SubjectFull: Antimicrobial bandages
        Type: general
      – SubjectFull: Lactic acid
        Type: general
      – SubjectFull: Hydroxides
        Type: general
      – SubjectFull: Nanofibers
        Type: general
      – SubjectFull: Silver sulfadiazine
        Type: general
      – SubjectFull: Magnesium ions
        Type: general
      – SubjectFull: Scanning electron microscopy
        Type: general
    Titles:
      – TitleFull: Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]‐layered double hydroxide as an antimicrobial wound dressing.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Malafatti, João O. D.
      – PersonEntity:
          Name:
            NameFull: Bernardo, Marcela P.
      – PersonEntity:
          Name:
            NameFull: Moreira, Francys K. V.
      – PersonEntity:
          Name:
            NameFull: Ciol, Heloisa
      – PersonEntity:
          Name:
            NameFull: Inada, Natalia M.
      – PersonEntity:
          Name:
            NameFull: Mattoso, Luiz H.C.
      – PersonEntity:
          Name:
            NameFull: Paris, Elaine C.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 10427147
          Numbering:
            – Type: volume
              Value: 31
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Polymers for Advanced Technologies
              Type: main
ResultId 1