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Artemilavanolides A and B, two sesquiterpenoids with a 6-oxabicyclo[3.2.1]octane scaffold from Artemisia lavandulaefolia.

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Title: Artemilavanolides A and B, two sesquiterpenoids with a 6-oxabicyclo[3.2.1]octane scaffold from Artemisia lavandulaefolia.
Authors: Ding, Lin-Fen1,2 (AUTHOR), Peng, Li-Yan1 (AUTHOR), Zhou, Hao-Feng1 (AUTHOR), Song, Liu-Dong2 (AUTHOR), Wu, Xing-De1 (AUTHOR) wuxingde@mail.kib.ac.cn, Zhao, Qin-Shi1 (AUTHOR) qinshizhao@mail.kib.ac.cn
Source: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. May2020, Vol. 61 Issue 21, pN.PAG-N.PAG. 1p.
Subjects: Sesquiterpenes, Artemisia, Single crystals, Circular dichroism
Abstract: • Two unprecedented sesquiterpenoids were obtained from Artemisia lavandulaefolia. • The structures of 1 and 2 possessed 6-oxabicyclo[3.2.1]octane scaffold. • The absolute configurations of 1 and 2 were established by analysis of ECD data. • Compound 1 exhibit moderate neurotrophic activity. Artemilavanolides A (1) and B (2), two unprecedented sesquiterpenoids with 6-oxabicyclo[3.2.1]octane scaffold, as well as one known biogenetically related sesquiterpenoid, 11 β ,13-dihydrosantamarin (3), were isolated from the aerial parts of Artemisia lavandulaefolia. The structures and absolute configurations of 1 and 2 were characterized by analysis of HRESIMS, NMR spectroscopic, single crystal X-ray diffraction, and electronic circular dichroism (ECD) data. The plausible biogenetic pathway for 1 and 2 was also proposed. Compound 1 was found to enhance the neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 μM. [ABSTRACT FROM AUTHOR]
Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 143100380
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Artemilavanolides A and B, two sesquiterpenoids with a 6-oxabicyclo[3.2.1]octane scaffold from Artemisia lavandulaefolia.
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  Data: • Two unprecedented sesquiterpenoids were obtained from Artemisia lavandulaefolia. • The structures of 1 and 2 possessed 6-oxabicyclo[3.2.1]octane scaffold. • The absolute configurations of 1 and 2 were established by analysis of ECD data. • Compound 1 exhibit moderate neurotrophic activity. Artemilavanolides A (1) and B (2), two unprecedented sesquiterpenoids with 6-oxabicyclo[3.2.1]octane scaffold, as well as one known biogenetically related sesquiterpenoid, 11 β ,13-dihydrosantamarin (3), were isolated from the aerial parts of Artemisia lavandulaefolia. The structures and absolute configurations of 1 and 2 were characterized by analysis of HRESIMS, NMR spectroscopic, single crystal X-ray diffraction, and electronic circular dichroism (ECD) data. The plausible biogenetic pathway for 1 and 2 was also proposed. Compound 1 was found to enhance the neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 μM. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.tetlet.2020.151872
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              Text: May2020
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