Pathology and Host Immune Evasion During Human Leptospirosis: a Review.
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| Title: | Pathology and Host Immune Evasion During Human Leptospirosis: a Review. |
|---|---|
| Authors: | Chin, Voon Kin1,2 (AUTHOR) VoonKin.Chin@taylors.edu.my, Basir, R.3 (AUTHOR), Nordin, S. A.2 (AUTHOR), Abdullah, M.4 (AUTHOR), Sekawi, Z.2 (AUTHOR) |
| Source: | International Microbiology. May2020, Vol. 23 Issue 2, p127-136. 10p. |
| Subjects: | Leptospirosis, Zoonoses, Pathology, Molecular pathology, Leptospira, Natural immunity |
| Abstract: | Human leptospirosis is considered as one of the most widespread and potentially fatal zoonotic diseases that causes high mortality and morbidity in the endemic regions of tropical and subtropical countries. The infection can arise from direct or indirect exposure of human through contaminated environment that contains leptospires or animal reservoirs that carry leptospires. The clinical manifestations during human leptospirosis ranges from asymptomatic, mild infections to severe and life-threatening complications involving multi-organ failures with kidneys, lungs and liver severely affected. Despite much efforts have been put in to unravel the pathogenesis during human leptospirosis, it remains obscure to which extent the host factors or the pathogen itself contribute towards the pathogenesis. Host innate immunity, especially, polymorphonuclear neutrophils and complement system are involved in the first line of defense during human leptospirosis. However, pathogenic Leptospira has acquired diverse evasion strategies to evade from host immunity and establish infection in infected hosts. Hence, in this review, we focus on organs pathology during human leptospiral infection and host evasion strategies employed by Leptospira. A profound understanding on leptospiral immunity and how Leptospira subvert the immune system may provide new insights on the development of therapeutic regimens against this species in future. [ABSTRACT FROM AUTHOR] |
| Copyright of International Microbiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 143245531 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Pathology and Host Immune Evasion During Human Leptospirosis: a Review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chin%2C+Voon+Kin%22">Chin, Voon Kin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> VoonKin.Chin@taylors.edu.my</i><br /><searchLink fieldCode="AR" term="%22Basir%2C+R%2E%22">Basir, R.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nordin%2C+S%2E+A%2E%22">Nordin, S. A.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abdullah%2C+M%2E%22">Abdullah, M.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sekawi%2C+Z%2E%22">Sekawi, Z.</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Microbiology%22">International Microbiology</searchLink>. May2020, Vol. 23 Issue 2, p127-136. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Leptospirosis%22">Leptospirosis</searchLink><br /><searchLink fieldCode="DE" term="%22Zoonoses%22">Zoonoses</searchLink><br /><searchLink fieldCode="DE" term="%22Pathology%22">Pathology</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+pathology%22">Molecular pathology</searchLink><br /><searchLink fieldCode="DE" term="%22Leptospira%22">Leptospira</searchLink><br /><searchLink fieldCode="DE" term="%22Natural+immunity%22">Natural immunity</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Human leptospirosis is considered as one of the most widespread and potentially fatal zoonotic diseases that causes high mortality and morbidity in the endemic regions of tropical and subtropical countries. The infection can arise from direct or indirect exposure of human through contaminated environment that contains leptospires or animal reservoirs that carry leptospires. The clinical manifestations during human leptospirosis ranges from asymptomatic, mild infections to severe and life-threatening complications involving multi-organ failures with kidneys, lungs and liver severely affected. Despite much efforts have been put in to unravel the pathogenesis during human leptospirosis, it remains obscure to which extent the host factors or the pathogen itself contribute towards the pathogenesis. Host innate immunity, especially, polymorphonuclear neutrophils and complement system are involved in the first line of defense during human leptospirosis. However, pathogenic Leptospira has acquired diverse evasion strategies to evade from host immunity and establish infection in infected hosts. Hence, in this review, we focus on organs pathology during human leptospiral infection and host evasion strategies employed by Leptospira. A profound understanding on leptospiral immunity and how Leptospira subvert the immune system may provide new insights on the development of therapeutic regimens against this species in future. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Microbiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10123-019-00067-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 127 Subjects: – SubjectFull: Leptospirosis Type: general – SubjectFull: Zoonoses Type: general – SubjectFull: Pathology Type: general – SubjectFull: Molecular pathology Type: general – SubjectFull: Leptospira Type: general – SubjectFull: Natural immunity Type: general Titles: – TitleFull: Pathology and Host Immune Evasion During Human Leptospirosis: a Review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chin, Voon Kin – PersonEntity: Name: NameFull: Basir, R. – PersonEntity: Name: NameFull: Nordin, S. A. – PersonEntity: Name: NameFull: Abdullah, M. – PersonEntity: Name: NameFull: Sekawi, Z. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 11396709 Numbering: – Type: volume Value: 23 – Type: issue Value: 2 Titles: – TitleFull: International Microbiology Type: main |
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