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Effects of the combination of low-level laser therapy and anionic polymer membranes on bone repair.

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Title: Effects of the combination of low-level laser therapy and anionic polymer membranes on bone repair.
Authors: dos Santos, Daniel Alves1, de Guzzi Plepis, Ana Maria2, da Conceição Amaro Martins, Virginia3, Cardoso, Guinea Brasil Camargo4, Santos, Arnaldo Rodrigues5, Iatecola, Amilton1, Andrade, Tiago Neves1, Monteiro, Fabrício Moreira1, Calegari, Amanda Regina Alves1, Chacon, Erivelto Luis1, Cunha, Marcelo Rodrigues1,2 cunhamr@hotmail.com, Santos, Arnaldo Rodrigues Jr5
Source: Lasers in Medical Science. Jun2020, Vol. 35 Issue 4, p813-821. 9p.
Subjects: Tissue engineering, Tissue scaffolds, Bone growth, Osteoarthritis, Randomized controlled trials, Artificial membranes, Bones, Cattle, Animal experimentation, Anthropometry, Swine, Rats, Polymers, Research funding, Bone regeneration, Combined modality therapy, Physiological effects of radiation
Abstract: In view of the limitations of bone reconstruction surgeries using autologous grafts as a gold standard, tissue engineering is emerging as an alternative, which permits the fabrication and improvement of scaffolds to stimulate osteogenesis and angiogenesis, processes that are essential for bone repair. Polymers are used to mimic the extracellular bone matrix and support cell growth. In addition, bone neoformation can be induced by external factors such as laser irradiation, which stimulates bone metabolism. The objective of this study was to evaluate the regeneration of bone defects using collagen and elastin membranes derived from intestinal serosa and bovine auricular cartilage combined with low-level laser application. Thirty-six Wistar rats were operated to create a 3-mm defect in the distal metaphysis of the left femur and divided into six groups: G1 (control, no treatment); G2 (laser); G3 (elastin graft), G4 (elastin+laser); G5 (collagen graft); G6 (collagen+laser). The animals were sacrificed 6 weeks after surgery and the femurs were removed for analysis of bone repair. Macroscopic and radiological results showed the absence of an infectious process in the surgical area. This was confirmed by histological analysis, which revealed no inflammatory infiltrate. Histomorphometry showed that the formation of new bone started from the margins of the bone defect and its volume was greater in elastin+laser and collagen+laser. We conclude that newly formed bone in the graft area was higher in the groups that received the biomaterials and laser. The collagen and elastin matrices showed biocompatibility. [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Effects of the combination of low-level laser therapy and anionic polymer membranes on bone repair.
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  Data: <searchLink fieldCode="AR" term="%22dos+Santos%2C+Daniel+Alves%22">dos Santos, Daniel Alves</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22de+Guzzi+Plepis%2C+Ana+Maria%22">de Guzzi Plepis, Ana Maria</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22da+Conceição+Amaro+Martins%2C+Virginia%22">da Conceição Amaro Martins, Virginia</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cardoso%2C+Guinea+Brasil+Camargo%22">Cardoso, Guinea Brasil Camargo</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Santos%2C+Arnaldo+Rodrigues%22">Santos, Arnaldo Rodrigues</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Iatecola%2C+Amilton%22">Iatecola, Amilton</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Andrade%2C+Tiago+Neves%22">Andrade, Tiago Neves</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Monteiro%2C+Fabrício+Moreira%22">Monteiro, Fabrício Moreira</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Calegari%2C+Amanda+Regina+Alves%22">Calegari, Amanda Regina Alves</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chacon%2C+Erivelto+Luis%22">Chacon, Erivelto Luis</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cunha%2C+Marcelo+Rodrigues%22">Cunha, Marcelo Rodrigues</searchLink><relatesTo>1,2</relatesTo><i> cunhamr@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Santos%2C+Arnaldo+Rodrigues+Jr%22">Santos, Arnaldo Rodrigues Jr</searchLink><relatesTo>5</relatesTo>
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  Data: In view of the limitations of bone reconstruction surgeries using autologous grafts as a gold standard, tissue engineering is emerging as an alternative, which permits the fabrication and improvement of scaffolds to stimulate osteogenesis and angiogenesis, processes that are essential for bone repair. Polymers are used to mimic the extracellular bone matrix and support cell growth. In addition, bone neoformation can be induced by external factors such as laser irradiation, which stimulates bone metabolism. The objective of this study was to evaluate the regeneration of bone defects using collagen and elastin membranes derived from intestinal serosa and bovine auricular cartilage combined with low-level laser application. Thirty-six Wistar rats were operated to create a 3-mm defect in the distal metaphysis of the left femur and divided into six groups: G1 (control, no treatment); G2 (laser); G3 (elastin graft), G4 (elastin+laser); G5 (collagen graft); G6 (collagen+laser). The animals were sacrificed 6 weeks after surgery and the femurs were removed for analysis of bone repair. Macroscopic and radiological results showed the absence of an infectious process in the surgical area. This was confirmed by histological analysis, which revealed no inflammatory infiltrate. Histomorphometry showed that the formation of new bone started from the margins of the bone defect and its volume was greater in elastin+laser and collagen+laser. We conclude that newly formed bone in the graft area was higher in the groups that received the biomaterials and laser. The collagen and elastin matrices showed biocompatibility. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10103-019-02864-8
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        Type: general
      – SubjectFull: Tissue scaffolds
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      – SubjectFull: Bone growth
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      – SubjectFull: Osteoarthritis
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      – SubjectFull: Artificial membranes
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              Text: Jun2020
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