View in EDS

Quantification of bis(2-ethylhexyl) phthalate released by medical devices during respiratory assistance and estimation of patient exposure.

Saved in:
Bibliographic Details
Title: Quantification of bis(2-ethylhexyl) phthalate released by medical devices during respiratory assistance and estimation of patient exposure.
Authors: Bouattour, Yassine1 (AUTHOR) ybouattour@chu-clermontferrand.fr, Wasiak, Mathieu2 (AUTHOR), Bernard, Lise1 (AUTHOR), Pinguet, Jérémy3 (AUTHOR), Richard, Damien3 (AUTHOR), Le Rouzo-Grèves, Mégane1 (AUTHOR), Dhifallah, Imen1 (AUTHOR), Lambert, Céline4 (AUTHOR), Pereira, Bruno4 (AUTHOR), Chennell, Philip1 (AUTHOR), Sautou, Valérie1 (AUTHOR)
Source: Chemosphere. Sep2020, Vol. 255, pN.PAG-N.PAG. 1p.
Subjects: Medical equipment, Phthalate esters, Plasticizers, Polyvinyl chloride, Noninvasive ventilation, Catheters
Abstract: Bis(2-ethylhexyl) phthalate (DEHP) migration from polyvinyl chloride (PVC) has been studied with infusion, transfusion and extracorporeal oxygenation devices, but no study has been conducted to estimate its migration via respiratory medical devices (MDs). This work aims to develop an ex vivo model to quantify DEHP released doses by these MDs, which will then be used to estimate newborns DEHP exposure from respiratory assistance MDs. We followed the Frensh National Research and Safety Institute (INRS) recommendations for the validation of a collecting and analysing method of DEHP in air, which will be used to quantify DEHP in air passing through PVC respiratory assistance MDs. The developed method met all the validation criteria for DEHP determination in air. DEHP in air passing through MDs on the sixth day reached a cumulative quantity of 122.86 μg when using a flow rate of 4 L min-1 of non-humidified air while it was of 49.22 μg; 58.12 μg and 29.61 μg with flow rates of 2 L min-1 of humidified air, 2 L min-1 of dry air and 4 L min-1 of humidified air, respectively. Model application to two patients undergoing two different respiratory procedure demonstrated that noninvasive ventilation patient received higher dose of inhaled DEHP, confirmed by DEHP metabolites quantification in urine. Although the protective effect of air humidifiers on DEHP exposure was demonstrated, the effect of flow rate is difficult to be established. This developed method should be tested to verify its capacity to collect and quantify other plasticizers used in PVC MDs. Image 1 • The method allows the determination of DEHP in air passing through an oxygen cannula • The use of an air humidifier could protect patients from DEHP respiratory exposure • The model could be used to estimate DEHP exposure via PVC respiratory devices [ABSTRACT FROM AUTHOR]
Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 143557727
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Quantification of bis(2-ethylhexyl) phthalate released by medical devices during respiratory assistance and estimation of patient exposure.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bouattour%2C+Yassine%22">Bouattour, Yassine</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ybouattour@chu-clermontferrand.fr</i><br /><searchLink fieldCode="AR" term="%22Wasiak%2C+Mathieu%22">Wasiak, Mathieu</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bernard%2C+Lise%22">Bernard, Lise</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pinguet%2C+Jérémy%22">Pinguet, Jérémy</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Richard%2C+Damien%22">Richard, Damien</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Le+Rouzo-Grèves%2C+Mégane%22">Le Rouzo-Grèves, Mégane</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dhifallah%2C+Imen%22">Dhifallah, Imen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lambert%2C+Céline%22">Lambert, Céline</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pereira%2C+Bruno%22">Pereira, Bruno</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chennell%2C+Philip%22">Chennell, Philip</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sautou%2C+Valérie%22">Sautou, Valérie</searchLink><relatesTo>1</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Chemosphere%22">Chemosphere</searchLink>. Sep2020, Vol. 255, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Medical+equipment%22">Medical equipment</searchLink><br /><searchLink fieldCode="DE" term="%22Phthalate+esters%22">Phthalate esters</searchLink><br /><searchLink fieldCode="DE" term="%22Plasticizers%22">Plasticizers</searchLink><br /><searchLink fieldCode="DE" term="%22Polyvinyl+chloride%22">Polyvinyl chloride</searchLink><br /><searchLink fieldCode="DE" term="%22Noninvasive+ventilation%22">Noninvasive ventilation</searchLink><br /><searchLink fieldCode="DE" term="%22Catheters%22">Catheters</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Bis(2-ethylhexyl) phthalate (DEHP) migration from polyvinyl chloride (PVC) has been studied with infusion, transfusion and extracorporeal oxygenation devices, but no study has been conducted to estimate its migration via respiratory medical devices (MDs). This work aims to develop an ex vivo model to quantify DEHP released doses by these MDs, which will then be used to estimate newborns DEHP exposure from respiratory assistance MDs. We followed the Frensh National Research and Safety Institute (INRS) recommendations for the validation of a collecting and analysing method of DEHP in air, which will be used to quantify DEHP in air passing through PVC respiratory assistance MDs. The developed method met all the validation criteria for DEHP determination in air. DEHP in air passing through MDs on the sixth day reached a cumulative quantity of 122.86 μg when using a flow rate of 4 L min-1 of non-humidified air while it was of 49.22 μg; 58.12 μg and 29.61 μg with flow rates of 2 L min-1 of humidified air, 2 L min-1 of dry air and 4 L min-1 of humidified air, respectively. Model application to two patients undergoing two different respiratory procedure demonstrated that noninvasive ventilation patient received higher dose of inhaled DEHP, confirmed by DEHP metabolites quantification in urine. Although the protective effect of air humidifiers on DEHP exposure was demonstrated, the effect of flow rate is difficult to be established. This developed method should be tested to verify its capacity to collect and quantify other plasticizers used in PVC MDs. Image 1 • The method allows the determination of DEHP in air passing through an oxygen cannula • The use of an air humidifier could protect patients from DEHP respiratory exposure • The model could be used to estimate DEHP exposure via PVC respiratory devices [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=143557727
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.chemosphere.2020.126978
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Medical equipment
        Type: general
      – SubjectFull: Phthalate esters
        Type: general
      – SubjectFull: Plasticizers
        Type: general
      – SubjectFull: Polyvinyl chloride
        Type: general
      – SubjectFull: Noninvasive ventilation
        Type: general
      – SubjectFull: Catheters
        Type: general
    Titles:
      – TitleFull: Quantification of bis(2-ethylhexyl) phthalate released by medical devices during respiratory assistance and estimation of patient exposure.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bouattour, Yassine
      – PersonEntity:
          Name:
            NameFull: Wasiak, Mathieu
      – PersonEntity:
          Name:
            NameFull: Bernard, Lise
      – PersonEntity:
          Name:
            NameFull: Pinguet, Jérémy
      – PersonEntity:
          Name:
            NameFull: Richard, Damien
      – PersonEntity:
          Name:
            NameFull: Le Rouzo-Grèves, Mégane
      – PersonEntity:
          Name:
            NameFull: Dhifallah, Imen
      – PersonEntity:
          Name:
            NameFull: Lambert, Céline
      – PersonEntity:
          Name:
            NameFull: Pereira, Bruno
      – PersonEntity:
          Name:
            NameFull: Chennell, Philip
      – PersonEntity:
          Name:
            NameFull: Sautou, Valérie
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 09
              Text: Sep2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 00456535
          Numbering:
            – Type: volume
              Value: 255
          Titles:
            – TitleFull: Chemosphere
              Type: main
ResultId 1