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A Precise Nanostructure of Folate-Overhung Mitoxantrone DNA Tetrahedron for Targeted Capture Leukemia.

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Title: A Precise Nanostructure of Folate-Overhung Mitoxantrone DNA Tetrahedron for Targeted Capture Leukemia.
Authors: Bu, Ying-Zi1 (AUTHOR) eiko@pku.edu.cn, Xu, Jia-Rui1 (AUTHOR), Luo, Qian1 (AUTHOR), Chen, Ming1 (AUTHOR), Mu, Li-Min1 (AUTHOR), Lu, Wan-Liang1 (AUTHOR) luwl@bjmu.edu.cn
Source: Nanomaterials (2079-4991). May2020, Vol. 10 Issue 5, p951. 1p.
Subjects: DNA, Mitoxantrone, Leukemia, Cancer cells, Apoptosis, Tetrahedra, Homocysteine
Abstract: Regular chemotherapy cannot eliminate leukemic cells, due to the sparse distribution of cancer cells in leukemia patients. Here, we report a precise nanostructure of folate-overhung mitoxantrone DNA tetrahedron that enables the treatment of leukemic cells by targeted action. Folate is used as a targeting molecule and synthesized with DNA strand in forming the folate-overhang DNA complement, and the complement is then separately base-paired onto six sides of the fabricated DNA tetrahedron. Mitoxantrone is used as an anticancer agent and intercalated into the double strands of the folate-overhung DNA tetrahedron for drug loading. The evaluation studies are performed on leukemia BALL-1 and K562 cells. The results demonstrate that the folate-overhung mitoxantrone DNA tetrahedra (approximately 25nm) are able to target leukemic cells, transport across the nuclei membrane, induce the apoptosis, and enhance the overall efficacy of treating leukemic cells in vitro and in leukemia-bearing mice. This study provides a potential drug-containing DNA nanostructure, to clean the sparsely distributed leukemic cells in patients. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: A Precise Nanostructure of Folate-Overhung Mitoxantrone DNA Tetrahedron for Targeted Capture Leukemia.
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  Data: <searchLink fieldCode="AR" term="%22Bu%2C+Ying-Zi%22">Bu, Ying-Zi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> eiko@pku.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Xu%2C+Jia-Rui%22">Xu, Jia-Rui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luo%2C+Qian%22">Luo, Qian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Ming%22">Chen, Ming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mu%2C+Li-Min%22">Mu, Li-Min</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Wan-Liang%22">Lu, Wan-Liang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> luwl@bjmu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. May2020, Vol. 10 Issue 5, p951. 1p.
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  Data: <searchLink fieldCode="DE" term="%22DNA%22">DNA</searchLink><br /><searchLink fieldCode="DE" term="%22Mitoxantrone%22">Mitoxantrone</searchLink><br /><searchLink fieldCode="DE" term="%22Leukemia%22">Leukemia</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Tetrahedra%22">Tetrahedra</searchLink><br /><searchLink fieldCode="DE" term="%22Homocysteine%22">Homocysteine</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Regular chemotherapy cannot eliminate leukemic cells, due to the sparse distribution of cancer cells in leukemia patients. Here, we report a precise nanostructure of folate-overhung mitoxantrone DNA tetrahedron that enables the treatment of leukemic cells by targeted action. Folate is used as a targeting molecule and synthesized with DNA strand in forming the folate-overhang DNA complement, and the complement is then separately base-paired onto six sides of the fabricated DNA tetrahedron. Mitoxantrone is used as an anticancer agent and intercalated into the double strands of the folate-overhung DNA tetrahedron for drug loading. The evaluation studies are performed on leukemia BALL-1 and K562 cells. The results demonstrate that the folate-overhung mitoxantrone DNA tetrahedra (approximately 25nm) are able to target leukemic cells, transport across the nuclei membrane, induce the apoptosis, and enhance the overall efficacy of treating leukemic cells in vitro and in leukemia-bearing mice. This study provides a potential drug-containing DNA nanostructure, to clean the sparsely distributed leukemic cells in patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.3390/nano10050951
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: 951
    Subjects:
      – SubjectFull: DNA
        Type: general
      – SubjectFull: Mitoxantrone
        Type: general
      – SubjectFull: Leukemia
        Type: general
      – SubjectFull: Cancer cells
        Type: general
      – SubjectFull: Apoptosis
        Type: general
      – SubjectFull: Tetrahedra
        Type: general
      – SubjectFull: Homocysteine
        Type: general
    Titles:
      – TitleFull: A Precise Nanostructure of Folate-Overhung Mitoxantrone DNA Tetrahedron for Targeted Capture Leukemia.
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          Name:
            NameFull: Bu, Ying-Zi
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            NameFull: Xu, Jia-Rui
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            NameFull: Luo, Qian
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            NameFull: Chen, Ming
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            NameFull: Mu, Li-Min
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            NameFull: Lu, Wan-Liang
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              M: 05
              Text: May2020
              Type: published
              Y: 2020
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              Value: 10
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