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Sarcopenia in juvenile localized scleroderma: new insights on deep involvement.

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Title: Sarcopenia in juvenile localized scleroderma: new insights on deep involvement.
Authors: Flores Quispe, Silvia Karem Janet1 (AUTHOR), Cavaliere, Annachiara1 (AUTHOR), Weber, Michael2 (AUTHOR), Stramare, Roberto1 (AUTHOR), Zuliani, Monica1 (AUTHOR), Quaia, Emilio1 (AUTHOR), Zulian, Francesco3 (AUTHOR), Giraudo, Chiara1 (AUTHOR) chiara.giraudo@unipd.it
Source: European Radiology. Jul2020, Vol. 30 Issue 7, p4091-4097. 7p. 4 Color Photographs, 2 Charts.
Subjects: Scleroderma (Disease), Sarcopenia, Intraclass correlation, Magnetic resonance imaging, Bone marrow, Research evaluation, Retrospective studies, Leg
Abstract: Objectives: Juvenile localized scleroderma (JLS) is a rare chronic autoimmune disease which can also affect bones and muscles. Nevertheless, muscle loss was not previously investigated in patients with JLS. Thus, the aim of this study was to retrospectively evaluate deep involvement and assess and quantify sarcopenia in JLS patients using magnetic resonance imaging (MRI).Methods: Fourteen children with JLS (nine females, mean age ± SD, 7.1 ± 3.6 years) referring to our tertiary center from January 2012 to January 2018 who underwent at least one MRI examination including axial T1-weighted and short tau inversion recovery images were included. Two readers assessed in consensus superficial and deep involvement. Muscle edema, muscle fatty infiltration, and sarcopenia were independently scored (absent, moderate, or severe) and the Cohen's kappa coefficient computed. Skin perimeter, subcutaneous area, muscle area, and muscle volume were independently measured using the contralateral unaffected extremity as reference (paired Student's t test, p < 0.05). The intraclass correlation coefficient (ICC) was used to investigate the reliability of the measurements.Results: All patients showed superficial involvement with subcutaneous fat atrophy being the most common finding (13 patients). Bone marrow edema occurred in five patients. Muscle edema affected ten children (moderate in seven, severe in three; k = 0.89), muscle fatty replacement occurred in one case (severe; k = 1.00), and sarcopenia was detected in eight patients (severe in two; k = 0.78). All quantitative parameters were lower on the affected side than on the unaffected contralateral limb (p < 0.05, each) and all measurements showed a high reliability (ICC > 0.750, each).Conclusion: Patients with JLS can be affected by sarcopenia and quantitative analyses allow a robust characterization of such finding.Key Points: • Deep involvement in juvenile localized scleroderma is frequently characterized by sarcopenia. • In juvenile localized scleroderma, muscle edema and sarcopenia are mostly moderate while fatty infiltration, even if rare, can be severe. • Sarcopenia can be reliably quantified in children with juvenile localized scleroderma using MRI. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Sarcopenia in juvenile localized scleroderma: new insights on deep involvement.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Flores+Quispe%2C+Silvia+Karem+Janet%22&quot;&gt;Flores Quispe, Silvia Karem Janet&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cavaliere%2C+Annachiara%22&quot;&gt;Cavaliere, Annachiara&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Weber%2C+Michael%22&quot;&gt;Weber, Michael&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stramare%2C+Roberto%22&quot;&gt;Stramare, Roberto&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zuliani%2C+Monica%22&quot;&gt;Zuliani, Monica&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Quaia%2C+Emilio%22&quot;&gt;Quaia, Emilio&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zulian%2C+Francesco%22&quot;&gt;Zulian, Francesco&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Giraudo%2C+Chiara%22&quot;&gt;Giraudo, Chiara&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; chiara.giraudo@unipd.it&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Jul2020, Vol. 30 Issue 7, p4091-4097. 7p. 4 Color Photographs, 2 Charts.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Scleroderma+%28Disease%29%22&quot;&gt;Scleroderma (Disease)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sarcopenia%22&quot;&gt;Sarcopenia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Intraclass+correlation%22&quot;&gt;Intraclass correlation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetic+resonance+imaging%22&quot;&gt;Magnetic resonance imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bone+marrow%22&quot;&gt;Bone marrow&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Research+evaluation%22&quot;&gt;Research evaluation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Retrospective+studies%22&quot;&gt;Retrospective studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Leg%22&quot;&gt;Leg&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: &lt;bold&gt;Objectives: &lt;/bold&gt;Juvenile localized scleroderma (JLS) is a rare chronic autoimmune disease which can also affect bones and muscles. Nevertheless, muscle loss was not previously investigated in patients with JLS. Thus, the aim of this study was to retrospectively evaluate deep involvement and assess and quantify sarcopenia in JLS patients using magnetic resonance imaging (MRI).&lt;bold&gt;Methods: &lt;/bold&gt;Fourteen children with JLS (nine females, mean age &#177; SD, 7.1 &#177; 3.6&#160;years) referring to our tertiary center from January 2012 to January 2018 who underwent at least one MRI examination including axial T1-weighted and short tau inversion recovery images were included. Two readers assessed in consensus superficial and deep involvement. Muscle edema, muscle fatty infiltration, and sarcopenia were independently scored (absent, moderate, or severe) and the Cohen&#39;s kappa coefficient computed. Skin perimeter, subcutaneous area, muscle area, and muscle volume were independently measured using the contralateral unaffected extremity as reference (paired Student&#39;s t test, p &lt; 0.05). The intraclass correlation coefficient (ICC) was used to investigate the reliability of the measurements.&lt;bold&gt;Results: &lt;/bold&gt;All patients showed superficial involvement with subcutaneous fat atrophy being the most common finding (13 patients). Bone marrow edema occurred in five patients. Muscle edema affected ten children (moderate in seven, severe in three; k = 0.89), muscle fatty replacement occurred in one case (severe; k = 1.00), and sarcopenia was detected in eight patients (severe in two; k = 0.78). All quantitative parameters were lower on the affected side than on the unaffected contralateral limb (p &lt; 0.05, each) and all measurements showed a high reliability (ICC &gt; 0.750, each).&lt;bold&gt;Conclusion: &lt;/bold&gt;Patients with JLS can be affected by sarcopenia and quantitative analyses allow a robust characterization of such finding.&lt;bold&gt;Key Points: &lt;/bold&gt;• Deep involvement in juvenile localized scleroderma is frequently characterized by sarcopenia. • In juvenile localized scleroderma, muscle edema and sarcopenia are mostly moderate while fatty infiltration, even if rare, can be severe. • Sarcopenia can be reliably quantified in children with juvenile localized scleroderma using MRI. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-020-06764-2
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      – SubjectFull: Scleroderma (Disease)
        Type: general
      – SubjectFull: Sarcopenia
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      – SubjectFull: Intraclass correlation
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      – SubjectFull: Leg
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              Text: Jul2020
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