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Multi-institutional dosimetric delivery assessment of intracranial stereotactic radiosurgery on different treatment platforms.

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Title: Multi-institutional dosimetric delivery assessment of intracranial stereotactic radiosurgery on different treatment platforms.
Authors: Dimitriadis, Alexis1,2,3 (AUTHOR) alex@physicsconsulting.co.uk, Tsang, Yatman4 (AUTHOR), Thomas, Russell A.S.2 (AUTHOR), Palmer, Antony L.1,5 (AUTHOR), Eaton, David4 (AUTHOR), Lee, Jonathan4 (AUTHOR), Patel, Rushil4 (AUTHOR), Silvestre Patallo, Ileana2 (AUTHOR), Gouldstone, Clare2 (AUTHOR), Snaith, Julia A.D.2 (AUTHOR), Kirkby, Karen J.6,7 (AUTHOR), Nisbet, Andrew2,8 (AUTHOR), Clark, Catharine H.1,2,3,4 (AUTHOR)
Source: Radiotherapy & Oncology. Jun2020, Vol. 147, p153-161. 9p.
Subjects: Stereotactic radiosurgery, Alanine, Linear accelerators, Brain stem
Abstract: • A multi-institutional end-to-end assessment of radiosurgery dosimetric delivery was performed for 33 plans in 30 participating centres using a variety of treatment platforms. • The comparison has highlighted the dosimetric consistency achievable with different delivery platforms. • The need for standardisation in intracranial stereotactic radiosurgery is highlighted. Assessment of dosimetric accuracy of radiosurgery on different treatment platforms. Thirty-three single fraction treatment plans were assessed at thirty centres using an anthropomorphic head phantom with target and brainstem structures. The target being a single irregular shaped target, ~8 cc, 10 mm from the brainstem. The phantom was "immobilised", scanned, planned and treated following the local protocols. EBT-XD films and alanine pellets were used to measure absolute dose, inside both the target and the brainstem, and compared with TPS predicted dose distributions. PTV alanine measurements from gantry-based linacs showed a median percentage difference to the TPS of 0.65%. Cyberknife (CK) had the highest median difference of 2.3% in comparison to the other platforms. GammaKnife (GK) showed the smallest median of 0.3%. Similar trends were observed in the OAR with alanine measurements showing median percentage differences of1.1%, 2.0% and 0.4%, for gantry-based linacs, CK and GK respectively. All platforms showed comparable gamma passing rates between axial and sagittal films. This comparison has highlighted the dosimetric variation between measured and TPS calculated dose for each delivery platform. The results suggest that clinically acceptable agreement with the predicted dose distributions is achievable by all treatment delivery systems. [ABSTRACT FROM AUTHOR]
Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 143860039
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PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Multi-institutional dosimetric delivery assessment of intracranial stereotactic radiosurgery on different treatment platforms.
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  Data: <searchLink fieldCode="AR" term="%22Dimitriadis%2C+Alexis%22">Dimitriadis, Alexis</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> alex@physicsconsulting.co.uk</i><br /><searchLink fieldCode="AR" term="%22Tsang%2C+Yatman%22">Tsang, Yatman</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomas%2C+Russell+A%2ES%2E%22">Thomas, Russell A.S.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Palmer%2C+Antony+L%2E%22">Palmer, Antony L.</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eaton%2C+David%22">Eaton, David</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jonathan%22">Lee, Jonathan</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patel%2C+Rushil%22">Patel, Rushil</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silvestre+Patallo%2C+Ileana%22">Silvestre Patallo, Ileana</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gouldstone%2C+Clare%22">Gouldstone, Clare</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Snaith%2C+Julia+A%2ED%2E%22">Snaith, Julia A.D.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kirkby%2C+Karen+J%2E%22">Kirkby, Karen J.</searchLink><relatesTo>6,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nisbet%2C+Andrew%22">Nisbet, Andrew</searchLink><relatesTo>2,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Clark%2C+Catharine+H%2E%22">Clark, Catharine H.</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Radiotherapy+%26+Oncology%22">Radiotherapy & Oncology</searchLink>. Jun2020, Vol. 147, p153-161. 9p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Stereotactic+radiosurgery%22">Stereotactic radiosurgery</searchLink><br /><searchLink fieldCode="DE" term="%22Alanine%22">Alanine</searchLink><br /><searchLink fieldCode="DE" term="%22Linear+accelerators%22">Linear accelerators</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+stem%22">Brain stem</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: • A multi-institutional end-to-end assessment of radiosurgery dosimetric delivery was performed for 33 plans in 30 participating centres using a variety of treatment platforms. • The comparison has highlighted the dosimetric consistency achievable with different delivery platforms. • The need for standardisation in intracranial stereotactic radiosurgery is highlighted. Assessment of dosimetric accuracy of radiosurgery on different treatment platforms. Thirty-three single fraction treatment plans were assessed at thirty centres using an anthropomorphic head phantom with target and brainstem structures. The target being a single irregular shaped target, ~8 cc, 10 mm from the brainstem. The phantom was "immobilised", scanned, planned and treated following the local protocols. EBT-XD films and alanine pellets were used to measure absolute dose, inside both the target and the brainstem, and compared with TPS predicted dose distributions. PTV alanine measurements from gantry-based linacs showed a median percentage difference to the TPS of 0.65%. Cyberknife (CK) had the highest median difference of 2.3% in comparison to the other platforms. GammaKnife (GK) showed the smallest median of 0.3%. Similar trends were observed in the OAR with alanine measurements showing median percentage differences of1.1%, 2.0% and 0.4%, for gantry-based linacs, CK and GK respectively. All platforms showed comparable gamma passing rates between axial and sagittal films. This comparison has highlighted the dosimetric variation between measured and TPS calculated dose for each delivery platform. The results suggest that clinically acceptable agreement with the predicted dose distributions is achievable by all treatment delivery systems. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.radonc.2020.05.024
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 153
    Subjects:
      – SubjectFull: Stereotactic radiosurgery
        Type: general
      – SubjectFull: Alanine
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      – SubjectFull: Linear accelerators
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      – SubjectFull: Brain stem
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              Text: Jun2020
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              Y: 2020
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