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Pathologic Hepatic Contrast-Enhanced Ultrasound Pattern in Patients Undergoing Allogeneic Stem Cell Transplantation.

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Title: Pathologic Hepatic Contrast-Enhanced Ultrasound Pattern in Patients Undergoing Allogeneic Stem Cell Transplantation.
Authors: Trenker, Corinna1 (AUTHOR) Trenker@med.uni-marburg.de, Burchert, Andreas1 (AUTHOR), Schumacher, Caren2 (AUTHOR), Schäfer, Jonas A.1 (AUTHOR), Dohse, Marius1 (AUTHOR), Timmesfeld, Nina3 (AUTHOR), Neubauer, Andreas1 (AUTHOR), Sohlbach, Kristina1 (AUTHOR), Michel, Christian1 (AUTHOR), Görg, Christian2 (AUTHOR)
Source: Ultrasound in Medicine & Biology. Aug2020, Vol. 46 Issue 8, p1865-1871. 7p.
Subjects: Stem cell transplantation, Contrast-enhanced ultrasound, Opacity (Optics), Hepatic veno-occlusive disease
Abstract: Veno-occlusive disease (VOD) is a severe complication of allogeneic stem cell transplantation (allo-SCT). Its diagnosis is difficult, and ultrasound (US) has not been proven to be of additional diagnostic value. In the work described here, we prospectively analyzed the hepatic contrast-enhanced ultrasound (CEUS) pattern before and after allo-SCT and correlated these results with the pre-allo-SCT VOD risk factors, clinical VOD findings and conventional US findings. Thirty consecutive patients who underwent allo-SCT and had at least one VOD risk factor were studied. B-Mode US and CEUS were longitudinally performed at defined time points before and after allo-SCT. The 1-min hepatic enhancement (OMHE) in CEUS was standardized to splenic enhancement and quantified using optical density (OD) measurement software. A hypo-OMHE was arbitrarily defined as pathologic (pOMHE) if the OD of the liver was less than 90% compared with the mean splenic OD. Twenty-one patients (70%) had a pOMHE, the occurrence of which peaked at day 10 after allo-SCT. The number of pre-treatment VOD risk factors significantly differed between the pathologic and non-pathologic OD groups. Together, patients undergoing allo-SCT frequently exhibit a pathologic hepatic CEUS pattern, which can be quantified by OD measurement and is suggestive of pre-clinical VOD or other hepatic pathologies. [ABSTRACT FROM AUTHOR]
Copyright of Ultrasound in Medicine & Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Pathologic Hepatic Contrast-Enhanced Ultrasound Pattern in Patients Undergoing Allogeneic Stem Cell Transplantation.
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  Data: <searchLink fieldCode="AR" term="%22Trenker%2C+Corinna%22">Trenker, Corinna</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> Trenker@med.uni-marburg.de</i><br /><searchLink fieldCode="AR" term="%22Burchert%2C+Andreas%22">Burchert, Andreas</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schumacher%2C+Caren%22">Schumacher, Caren</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schäfer%2C+Jonas+A%2E%22">Schäfer, Jonas A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dohse%2C+Marius%22">Dohse, Marius</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Timmesfeld%2C+Nina%22">Timmesfeld, Nina</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Neubauer%2C+Andreas%22">Neubauer, Andreas</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sohlbach%2C+Kristina%22">Sohlbach, Kristina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Michel%2C+Christian%22">Michel, Christian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Görg%2C+Christian%22">Görg, Christian</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Ultrasound+in+Medicine+%26+Biology%22">Ultrasound in Medicine & Biology</searchLink>. Aug2020, Vol. 46 Issue 8, p1865-1871. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Stem+cell+transplantation%22">Stem cell transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Contrast-enhanced+ultrasound%22">Contrast-enhanced ultrasound</searchLink><br /><searchLink fieldCode="DE" term="%22Opacity+%28Optics%29%22">Opacity (Optics)</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatic+veno-occlusive+disease%22">Hepatic veno-occlusive disease</searchLink>
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  Label: Abstract
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  Data: Veno-occlusive disease (VOD) is a severe complication of allogeneic stem cell transplantation (allo-SCT). Its diagnosis is difficult, and ultrasound (US) has not been proven to be of additional diagnostic value. In the work described here, we prospectively analyzed the hepatic contrast-enhanced ultrasound (CEUS) pattern before and after allo-SCT and correlated these results with the pre-allo-SCT VOD risk factors, clinical VOD findings and conventional US findings. Thirty consecutive patients who underwent allo-SCT and had at least one VOD risk factor were studied. B-Mode US and CEUS were longitudinally performed at defined time points before and after allo-SCT. The 1-min hepatic enhancement (OMHE) in CEUS was standardized to splenic enhancement and quantified using optical density (OD) measurement software. A hypo-OMHE was arbitrarily defined as pathologic (pOMHE) if the OD of the liver was less than 90% compared with the mean splenic OD. Twenty-one patients (70%) had a pOMHE, the occurrence of which peaked at day 10 after allo-SCT. The number of pre-treatment VOD risk factors significantly differed between the pathologic and non-pathologic OD groups. Together, patients undergoing allo-SCT frequently exhibit a pathologic hepatic CEUS pattern, which can be quantified by OD measurement and is suggestive of pre-clinical VOD or other hepatic pathologies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Ultrasound in Medicine & Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Contrast-enhanced ultrasound
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      – SubjectFull: Opacity (Optics)
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              Text: Aug2020
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