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Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior.

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Title: Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior.
Authors: Cramer, Madeline C.1,2 (AUTHOR), Badylak, Stephen F.1,2,3 (AUTHOR) badylaks@upmc.edu
Source: Annals of Biomedical Engineering. Jul2020, Vol. 48 Issue 7, p2132-2153. 22p. 1 Diagram, 1 Chart.
Subjects: Biomaterials, Tissue remodeling, Extracellular matrix, Immunoregulation, Stem cells, Progenitor cells, Tissue scaffolds
Abstract: Biologic scaffold materials composed of allogeneic or xenogeneic extracellular matrix (ECM) are commonly used for the repair and remodeling of injured tissue. The clinical outcomes associated with implantation of ECM-based materials range from unacceptable to excellent. The variable clinical results are largely due to differences in the preparation of the material, including characteristics of the source tissue, the method and efficacy of decellularization, and post-decellularization processing steps. The mechanisms by which ECM scaffolds promote constructive tissue remodeling include mechanical support, degradation and release of bioactive molecules, recruitment and differentiation of endogenous stem/progenitor cells, and modulation of the immune response toward an anti-inflammatory phenotype. The methods of ECM preparation and the impact of these methods on the quality of the final product are described herein. Examples of favorable cellular responses of immune and stem cells associated with constructive tissue remodeling of ECM bioscaffolds are described. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior.
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Jul2020, Vol. 48 Issue 7, p2132-2153. 22p. 1 Diagram, 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Biomaterials%22">Biomaterials</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+remodeling%22">Tissue remodeling</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+matrix%22">Extracellular matrix</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoregulation%22">Immunoregulation</searchLink><br /><searchLink fieldCode="DE" term="%22Stem+cells%22">Stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Progenitor+cells%22">Progenitor cells</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+scaffolds%22">Tissue scaffolds</searchLink>
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  Data: Biologic scaffold materials composed of allogeneic or xenogeneic extracellular matrix (ECM) are commonly used for the repair and remodeling of injured tissue. The clinical outcomes associated with implantation of ECM-based materials range from unacceptable to excellent. The variable clinical results are largely due to differences in the preparation of the material, including characteristics of the source tissue, the method and efficacy of decellularization, and post-decellularization processing steps. The mechanisms by which ECM scaffolds promote constructive tissue remodeling include mechanical support, degradation and release of bioactive molecules, recruitment and differentiation of endogenous stem/progenitor cells, and modulation of the immune response toward an anti-inflammatory phenotype. The methods of ECM preparation and the impact of these methods on the quality of the final product are described herein. Examples of favorable cellular responses of immune and stem cells associated with constructive tissue remodeling of ECM bioscaffolds are described. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10439-019-02408-9
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        Text: English
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        Type: general
      – SubjectFull: Tissue remodeling
        Type: general
      – SubjectFull: Extracellular matrix
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      – SubjectFull: Immunoregulation
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              Text: Jul2020
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