Improving Plasmonic Photothermal Therapy of Lung Cancer Cells with Anti-EGFR Targeted Gold Nanorods.
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| Title: | Improving Plasmonic Photothermal Therapy of Lung Cancer Cells with Anti-EGFR Targeted Gold Nanorods. |
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| Authors: | Knights, Oscar1 (AUTHOR) O.B.Knights@leeds.ac.uk, Freear, Steven1 (AUTHOR) s.freear@leeds.ac.uk, McLaughlan, James R.1,2 (AUTHOR) j.r.mclaughlan@leeds.ac.uk |
| Source: | Nanomaterials (2079-4991). Jul2020, Vol. 10 Issue 7, p1307. 1p. |
| Subjects: | Lung cancer, Continuous wave lasers, Cancer cells, Nanorods, Gold nanoparticles, Nanomedicine, Plasmons (Physics), Surface plasmon resonance |
| Abstract: | Lung cancer is a particularly difficult form of cancer to diagnose and treat, due largely to the inaccessibility of tumours and the limited available treatment options. The development of plasmonic gold nanoparticles has led to their potential use in a large range of disciplines, and they have shown promise for applications in this area. The ability to functionalise these nanoparticles to target to specific cancer types, when combined with minimally invasive therapies such as photothermal therapy, could improve long-term outcomes for lung cancer patients. Conventionally, continuous wave lasers are used to generate bulk heating enhanced by gold nanorods that have accumulated in the target region. However, there are potential negative side-effects of heat-induced cell death, such as the risk of damage to healthy tissue due to heat conducting to the surrounding environment, and the development of heat and drug resistance. In this study, the use of pulsed lasers for photothermal therapy was investigated and compared with continuous wave lasers for gold nanorods with a surface plasmon resonance at 850 nm, which were functionalised with anti-EGFR antibodies. Photothermal therapy was performed with both laser systems, on lung cancer cells (A549) in vitro populations incubated with untargeted and targeted nanorods. It was shown that the combination of pulse wave laser illumination of targeted nanoparticles produced a reduction of 93 % ± 13 % in the cell viability compared with control exposures, which demonstrates a possible application for minimally invasive therapies for lung cancer. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 144874579 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Improving Plasmonic Photothermal Therapy of Lung Cancer Cells with Anti-EGFR Targeted Gold Nanorods. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Knights%2C+Oscar%22">Knights, Oscar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> O.B.Knights@leeds.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Freear%2C+Steven%22">Freear, Steven</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> s.freear@leeds.ac.uk</i><br /><searchLink fieldCode="AR" term="%22McLaughlan%2C+James+R%2E%22">McLaughlan, James R.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> j.r.mclaughlan@leeds.ac.uk</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Jul2020, Vol. 10 Issue 7, p1307. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Lung+cancer%22">Lung cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Continuous+wave+lasers%22">Continuous wave lasers</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Nanorods%22">Nanorods</searchLink><br /><searchLink fieldCode="DE" term="%22Gold+nanoparticles%22">Gold nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Nanomedicine%22">Nanomedicine</searchLink><br /><searchLink fieldCode="DE" term="%22Plasmons+%28Physics%29%22">Plasmons (Physics)</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+plasmon+resonance%22">Surface plasmon resonance</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Lung cancer is a particularly difficult form of cancer to diagnose and treat, due largely to the inaccessibility of tumours and the limited available treatment options. The development of plasmonic gold nanoparticles has led to their potential use in a large range of disciplines, and they have shown promise for applications in this area. The ability to functionalise these nanoparticles to target to specific cancer types, when combined with minimally invasive therapies such as photothermal therapy, could improve long-term outcomes for lung cancer patients. Conventionally, continuous wave lasers are used to generate bulk heating enhanced by gold nanorods that have accumulated in the target region. However, there are potential negative side-effects of heat-induced cell death, such as the risk of damage to healthy tissue due to heat conducting to the surrounding environment, and the development of heat and drug resistance. In this study, the use of pulsed lasers for photothermal therapy was investigated and compared with continuous wave lasers for gold nanorods with a surface plasmon resonance at 850 nm, which were functionalised with anti-EGFR antibodies. Photothermal therapy was performed with both laser systems, on lung cancer cells (A549) in vitro populations incubated with untargeted and targeted nanorods. It was shown that the combination of pulse wave laser illumination of targeted nanoparticles produced a reduction of 93 % ± 13 % in the cell viability compared with control exposures, which demonstrates a possible application for minimally invasive therapies for lung cancer. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano10071307 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: 1307 Subjects: – SubjectFull: Lung cancer Type: general – SubjectFull: Continuous wave lasers Type: general – SubjectFull: Cancer cells Type: general – SubjectFull: Nanorods Type: general – SubjectFull: Gold nanoparticles Type: general – SubjectFull: Nanomedicine Type: general – SubjectFull: Plasmons (Physics) Type: general – SubjectFull: Surface plasmon resonance Type: general Titles: – TitleFull: Improving Plasmonic Photothermal Therapy of Lung Cancer Cells with Anti-EGFR Targeted Gold Nanorods. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Knights, Oscar – PersonEntity: Name: NameFull: Freear, Steven – PersonEntity: Name: NameFull: McLaughlan, James R. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 10 – Type: issue Value: 7 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
| ResultId | 1 |
