Non-Newtonian Effects on Patient-Specific Modeling of Fontan Hemodynamics.
Saved in:
| Title: | Non-Newtonian Effects on Patient-Specific Modeling of Fontan Hemodynamics. |
|---|---|
| Authors: | Wei, Zhenglun1 (AUTHOR), Singh-Gryzbon, Shelly1 (AUTHOR), Trusty, Phillip M.1 (AUTHOR), Huddleston, Connor2 (AUTHOR), Zhang, Yingnan1 (AUTHOR), Fogel, Mark A.3 (AUTHOR), Veneziani, Alessandro4 (AUTHOR), Yoganathan, Ajit P.1 (AUTHOR) ajit.yoganathan@bme.gatech.edu |
| Source: | Annals of Biomedical Engineering. Aug2020, Vol. 48 Issue 8, p2204-2217. 14p. 3 Diagrams, 4 Charts, 4 Graphs. |
| Subjects: | Non-Newtonian flow (Fluid dynamics), Shearing force, Rheology, Hemodynamics, Shear walls, Congenital heart disease |
| Abstract: | The Fontan procedure is a common palliative surgery for congenital single ventricle patients. In silico and in vitro patient-specific modeling approaches are widely utilized to investigate potential improvements of Fontan hemodynamics that are related to long-term complications. However, there is a lack of consensus regarding the use of non-Newtonian rheology, warranting a systematic investigation. This study conducted in silico patient-specific modeling for twelve Fontan patients, using a Newtonian and a non-Newtonian model for each patient. Differences were quantified by examining clinically relevant metrics: indexed power loss (iPL), indexed viscous dissipation rate (iVDR), hepatic flow distribution (HFD), and regions of low wall shear stress (AWSS). Four sets of "non-Newtonian importance factors" were calculated to explore their effectiveness in identifying the non-Newtonian effect. No statistical differences were observed in iPL, iVDR, and HFD between the two models at the population-level, but large inter-patient variations exist. Significant differences were detected regarding AWSS, and its correlations with non-Newtonian importance factors were discussed. Additionally, simulations using the non-Newtonian model were computationally faster than those using the Newtonian model. These findings distinguish good importance factors for identifying non-Newtonian rheology and encourage the use of a non-Newtonian model to assess Fontan hemodynamics. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
|
Full text is not displayed to guests.
Login for full access.
|
|
Be the first to leave a comment!
