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Effect of a new herbal composition comprised of red clover and hop extract on human endothelial cell damage and vasorelaxant activity.

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Title: Effect of a new herbal composition comprised of red clover and hop extract on human endothelial cell damage and vasorelaxant activity.
Authors: Jeon, Se Yeong1 (AUTHOR), Kim, Mi Ran1 (AUTHOR), Lee, Eun Ok2 (AUTHOR), Jeon, Byeong Hwa2 (AUTHOR), Lee, Jeong Jun1 (AUTHOR), Lee, Young Chul1 (AUTHOR) yclee@naturetech.co.kr
Source: Journal of Food Biochemistry. Aug2020, Vol. 44 Issue 8, p1-11. 11p.
Subjects: Red clover, Reactive oxygen species, Endothelial cells, Hops, Edible plants, Climacteric
Abstract: Hormone replacement therapy may cause various side effects, including enhancing the risk of cardiovascular disease (CVD) in postmenopausal women. Here, we investigated the effect of red clover and hop extract combination (RHEC) on estrogen receptor (ER) binding and endothelial function of human umbilical vein endothelial cells (HUVECs) to develop an herbal agent for reducing the risk of CVDs. In ER competitor assay, RHEC showed binding affinity toward ERα and ERβ with IC50 values of 5.92 µg/ml and 1.66 µg/ml, respectively. In HUVECs, RHEC significantly increased the cell viability and reduced the reactive oxygen species production against oxidative stress‐induced damage. We also showed that RHEC increased the NO production through upregulating the endothelial nitric oxide synthase expression via ER activation in estrogen depleted condition. In particular, RHEC showed greater efficacy with increase in NO and decrease in endothelin‐1 than red clover or hop treatment alone. Additionally, 0.3–0.5 mg/ml of RHEC‐induced vasorelaxation of rat aortic rings precontracted by phenylephrine. Practical applications: Recently, a large interest has grown in the synergistic effects of phytochemicals for better therapies to treat various diseases. Red clover and hop are well‐known edible plants which are widely used to help relieve postmenopausal symptoms including CVD. However, their combination has not been studied so far. For the first time, we demonstrated that RHEC, a new herbal combination comprising the extracts from red clover and hop, appeared to be effective in protection of endothelial function against oxidative stress and estrogen depletion. Therefore, RHEC could be a potent herbal agent for reducing the risk of endothelial damage. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Effect of a new herbal composition comprised of red clover and hop extract on human endothelial cell damage and vasorelaxant activity.
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  Data: <searchLink fieldCode="AR" term="%22Jeon%2C+Se+Yeong%22">Jeon, Se Yeong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Mi+Ran%22">Kim, Mi Ran</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Eun+Ok%22">Lee, Eun Ok</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jeon%2C+Byeong+Hwa%22">Jeon, Byeong Hwa</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jeong+Jun%22">Lee, Jeong Jun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Young+Chul%22">Lee, Young Chul</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yclee@naturetech.co.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. Aug2020, Vol. 44 Issue 8, p1-11. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Red+clover%22">Red clover</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelial+cells%22">Endothelial cells</searchLink><br /><searchLink fieldCode="DE" term="%22Hops%22">Hops</searchLink><br /><searchLink fieldCode="DE" term="%22Edible+plants%22">Edible plants</searchLink><br /><searchLink fieldCode="DE" term="%22Climacteric%22">Climacteric</searchLink>
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  Data: Hormone replacement therapy may cause various side effects, including enhancing the risk of cardiovascular disease (CVD) in postmenopausal women. Here, we investigated the effect of red clover and hop extract combination (RHEC) on estrogen receptor (ER) binding and endothelial function of human umbilical vein endothelial cells (HUVECs) to develop an herbal agent for reducing the risk of CVDs. In ER competitor assay, RHEC showed binding affinity toward ERα and ERβ with IC50 values of 5.92 µg/ml and 1.66 µg/ml, respectively. In HUVECs, RHEC significantly increased the cell viability and reduced the reactive oxygen species production against oxidative stress‐induced damage. We also showed that RHEC increased the NO production through upregulating the endothelial nitric oxide synthase expression via ER activation in estrogen depleted condition. In particular, RHEC showed greater efficacy with increase in NO and decrease in endothelin‐1 than red clover or hop treatment alone. Additionally, 0.3–0.5 mg/ml of RHEC‐induced vasorelaxation of rat aortic rings precontracted by phenylephrine. Practical applications: Recently, a large interest has grown in the synergistic effects of phytochemicals for better therapies to treat various diseases. Red clover and hop are well‐known edible plants which are widely used to help relieve postmenopausal symptoms including CVD. However, their combination has not been studied so far. For the first time, we demonstrated that RHEC, a new herbal combination comprising the extracts from red clover and hop, appeared to be effective in protection of endothelial function against oxidative stress and estrogen depletion. Therefore, RHEC could be a potent herbal agent for reducing the risk of endothelial damage. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/jfbc.13314
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        Text: English
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        PageCount: 11
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      – SubjectFull: Red clover
        Type: general
      – SubjectFull: Reactive oxygen species
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      – SubjectFull: Endothelial cells
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      – SubjectFull: Hops
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      – SubjectFull: Climacteric
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      – TitleFull: Effect of a new herbal composition comprised of red clover and hop extract on human endothelial cell damage and vasorelaxant activity.
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            NameFull: Jeon, Se Yeong
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              Text: Aug2020
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