Monascus purpureus-fermented common buckwheat protects against dyslipidemia and non-alcoholic fatty liver disease through the regulation of liver metabolome and intestinal microbiome.
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| Title: | Monascus purpureus-fermented common buckwheat protects against dyslipidemia and non-alcoholic fatty liver disease through the regulation of liver metabolome and intestinal microbiome. |
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| Authors: | Huang, Zi-Rui1 (AUTHOR), Chen, Min1 (AUTHOR), Guo, Wei-Ling1,2,3 (AUTHOR), Li, Tian-Tian1 (AUTHOR), Liu, Bin1,3 (AUTHOR) liubin618@hotmail.com, Bai, Wei-Dong4 (AUTHOR), Ai, Lian-Zhong5 (AUTHOR), Rao, Ping-Fan2 (AUTHOR), Ni, Li2 (AUTHOR), Lv, Xu-Cong1,2,3 (AUTHOR) xucong1154@163.com |
| Source: | Food Research International. Oct2020, Vol. 136, pN.PAG-N.PAG. 1p. |
| Subjects: | Fatty liver, Microbial metabolites, Buckwheat, Lipid metabolism, White adipose tissue, Monascus, Blood circulation, High cholesterol diet |
| Geographic Terms: | China |
| Abstract: | • M. purpureus- fermented common buckwheat has the potential to prevent NAFLD and dyslipidemia. • M. purpureus- fermented common buckwheat consumption significantly changed the hepatic metabolic profiles. • M. purpureus- fermented common buckwheat consumption modulated the intestinal microbial populations. • Hepatic mRNAs involved in lipid metabolism were regulated by M. purpureus- fermented common buckwheat. Monascus -fermented rice has been used to treat digestive disorder and promote blood circulation in China and other Asian countries for centuries. However, the effects and mechanisms of Monascus purpureus -fermented common buckwheat (HQ) on non-alcoholic fatty liver disease (NAFLD) and dyslipidemia are unclear. Here, oral supplementation of HQ significantly inhibited the abnormal growth of body weight and epididymal white adipose tissue (eWAT), prevented the hypertrophy of epididymal adipocytes, ameliorated some biochemical parameters of serum and liver related to lipid metabolism in mice fed a high-fat and high-cholesterol diet (HFD). Histological analysis also showed that the excessive accumulation of lipid droplets in the livers induced by HFD-feeding was greatly alleviated by HQ supplementation. Metagenomic analysis revealed that HQ supplementation made significant structural changes in the intestinal microflora of mice fed with HFD. The Spearman's correlation analysis revealed that physiological index, serum and liver lipid profiles were positively correlated with Bacteroidales S24-7, Streptococcus , Allobaculum , and Clostridiales XIII, but negatively associated with Lactobacillus , Ruminococcaceae_ NK4A214 group, Ruminiclostridium , and Alistipes. UPLC-QTOF/MS-based liver metabolomics demonstrated that HQ intervention had significant regulatory effects on the metabolic pathways of primary bile acid biosynthesis, pyrimidine metabolism, ether lipid metabolism, glutathione metabolism, glycine, serine and threonine metabolism, and amino sugar and nucleotide sugar metabolism, etc. Additionally, HQ intervention regulated the mRNA levels of hepatic genes involved in hepatic lipid metabolism and bile acid homeostasis. Collectively, these findings present new evidence supporting that HQ has the potential to ameliorate dyslipidemia and NAFLD via modulating the intestinal microbial populations and hepatic metabolite profile in hyperlipidemic mice induced by HFD. [ABSTRACT FROM AUTHOR] |
| Copyright of Food Research International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 145208937 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Monascus purpureus-fermented common buckwheat protects against dyslipidemia and non-alcoholic fatty liver disease through the regulation of liver metabolome and intestinal microbiome. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Huang%2C+Zi-Rui%22">Huang, Zi-Rui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Min%22">Chen, Min</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Wei-Ling%22">Guo, Wei-Ling</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Tian-Tian%22">Li, Tian-Tian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Bin%22">Liu, Bin</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> liubin618@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Bai%2C+Wei-Dong%22">Bai, Wei-Dong</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ai%2C+Lian-Zhong%22">Ai, Lian-Zhong</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rao%2C+Ping-Fan%22">Rao, Ping-Fan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ni%2C+Li%22">Ni, Li</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lv%2C+Xu-Cong%22">Lv, Xu-Cong</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> xucong1154@163.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Food+Research+International%22">Food Research International</searchLink>. Oct2020, Vol. 136, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Fatty+liver%22">Fatty liver</searchLink><br /><searchLink fieldCode="DE" term="%22Microbial+metabolites%22">Microbial metabolites</searchLink><br /><searchLink fieldCode="DE" term="%22Buckwheat%22">Buckwheat</searchLink><br /><searchLink fieldCode="DE" term="%22Lipid+metabolism%22">Lipid metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22White+adipose+tissue%22">White adipose tissue</searchLink><br /><searchLink fieldCode="DE" term="%22Monascus%22">Monascus</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+circulation%22">Blood circulation</searchLink><br /><searchLink fieldCode="DE" term="%22High+cholesterol+diet%22">High cholesterol diet</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22China%22">China</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: • M. purpureus- fermented common buckwheat has the potential to prevent NAFLD and dyslipidemia. • M. purpureus- fermented common buckwheat consumption significantly changed the hepatic metabolic profiles. • M. purpureus- fermented common buckwheat consumption modulated the intestinal microbial populations. • Hepatic mRNAs involved in lipid metabolism were regulated by M. purpureus- fermented common buckwheat. Monascus -fermented rice has been used to treat digestive disorder and promote blood circulation in China and other Asian countries for centuries. However, the effects and mechanisms of Monascus purpureus -fermented common buckwheat (HQ) on non-alcoholic fatty liver disease (NAFLD) and dyslipidemia are unclear. Here, oral supplementation of HQ significantly inhibited the abnormal growth of body weight and epididymal white adipose tissue (eWAT), prevented the hypertrophy of epididymal adipocytes, ameliorated some biochemical parameters of serum and liver related to lipid metabolism in mice fed a high-fat and high-cholesterol diet (HFD). Histological analysis also showed that the excessive accumulation of lipid droplets in the livers induced by HFD-feeding was greatly alleviated by HQ supplementation. Metagenomic analysis revealed that HQ supplementation made significant structural changes in the intestinal microflora of mice fed with HFD. The Spearman's correlation analysis revealed that physiological index, serum and liver lipid profiles were positively correlated with Bacteroidales S24-7, Streptococcus , Allobaculum , and Clostridiales XIII, but negatively associated with Lactobacillus , Ruminococcaceae_ NK4A214 group, Ruminiclostridium , and Alistipes. UPLC-QTOF/MS-based liver metabolomics demonstrated that HQ intervention had significant regulatory effects on the metabolic pathways of primary bile acid biosynthesis, pyrimidine metabolism, ether lipid metabolism, glutathione metabolism, glycine, serine and threonine metabolism, and amino sugar and nucleotide sugar metabolism, etc. Additionally, HQ intervention regulated the mRNA levels of hepatic genes involved in hepatic lipid metabolism and bile acid homeostasis. Collectively, these findings present new evidence supporting that HQ has the potential to ameliorate dyslipidemia and NAFLD via modulating the intestinal microbial populations and hepatic metabolite profile in hyperlipidemic mice induced by HFD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Food Research International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.foodres.2020.109511 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Fatty liver Type: general – SubjectFull: Microbial metabolites Type: general – SubjectFull: Buckwheat Type: general – SubjectFull: Lipid metabolism Type: general – SubjectFull: White adipose tissue Type: general – SubjectFull: Monascus Type: general – SubjectFull: Blood circulation Type: general – SubjectFull: High cholesterol diet Type: general – SubjectFull: China Type: general Titles: – TitleFull: Monascus purpureus-fermented common buckwheat protects against dyslipidemia and non-alcoholic fatty liver disease through the regulation of liver metabolome and intestinal microbiome. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Huang, Zi-Rui – PersonEntity: Name: NameFull: Chen, Min – PersonEntity: Name: NameFull: Guo, Wei-Ling – PersonEntity: Name: NameFull: Li, Tian-Tian – PersonEntity: Name: NameFull: Liu, Bin – PersonEntity: Name: NameFull: Bai, Wei-Dong – PersonEntity: Name: NameFull: Ai, Lian-Zhong – PersonEntity: Name: NameFull: Rao, Ping-Fan – PersonEntity: Name: NameFull: Ni, Li – PersonEntity: Name: NameFull: Lv, Xu-Cong IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 09639969 Numbering: – Type: volume Value: 136 Titles: – TitleFull: Food Research International Type: main |
| ResultId | 1 |
