A mechanobiological model to study upstream cell migration guided by tensotaxis.
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| Title: | A mechanobiological model to study upstream cell migration guided by tensotaxis. |
|---|---|
| Authors: | Rosalem, Gabriel Santos1 (AUTHOR), Las Casas, Estevam Barbosa2 (AUTHOR), Lima, Thiago Parente3 (AUTHOR), González-Torres, Libardo Andrés3 (AUTHOR) l.gonzales@ict.ufvjm.edu.br |
| Source: | Biomechanics & Modeling in Mechanobiology. Oct2020, Vol. 19 Issue 5, p1537-1549. 13p. |
| Subjects: | Cell migration, Nonlinear differential equations, Finite element method, Extracellular matrix, Human body |
| Abstract: | Cell migration is a process of crucial importance for the human body. It is responsible for important processes such as wound healing and tumor metastasis. Migration may occur in response to stimuli of chemical, physical and mechanical nature occurring in the cellular microenvironment. The interstitial flow (IF) can generate mechanical stimuli in cells that influence the cell behavior and interactions of the cells with the extracellular matrix (ECM). One of the phenomena is upstream migration, which is observed in some tumors. In this work, we present a new approach to study the adherent cell migration in a porous medium using a mechanobiological model, attempting to understand if upstream migration can be generated exclusively by mechanical factors. The influence of IF on the behavior of cells and the extracellular matrix was considered. The model is based on a system of coupled nonlinear differential equations solved by the finite element method. Several simulations were performed to study the upstream cell migration and evaluate the effects of pressure, permeability, ECM stiffness and cellular concentration variations on the cell velocity. The results indicated that upstream migration can occur in the presence of mechanical stimuli generated by IF and that the tested parameters have a direct influence on the cellular velocity, especially the pressure and the permeability. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 145976635 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A mechanobiological model to study upstream cell migration guided by tensotaxis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rosalem%2C+Gabriel+Santos%22">Rosalem, Gabriel Santos</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Las+Casas%2C+Estevam+Barbosa%22">Las Casas, Estevam Barbosa</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lima%2C+Thiago+Parente%22">Lima, Thiago Parente</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22González-Torres%2C+Libardo+Andrés%22">González-Torres, Libardo Andrés</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> l.gonzales@ict.ufvjm.edu.br</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Oct2020, Vol. 19 Issue 5, p1537-1549. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cell+migration%22">Cell migration</searchLink><br /><searchLink fieldCode="DE" term="%22Nonlinear+differential+equations%22">Nonlinear differential equations</searchLink><br /><searchLink fieldCode="DE" term="%22Finite+element+method%22">Finite element method</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+matrix%22">Extracellular matrix</searchLink><br /><searchLink fieldCode="DE" term="%22Human+body%22">Human body</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Cell migration is a process of crucial importance for the human body. It is responsible for important processes such as wound healing and tumor metastasis. Migration may occur in response to stimuli of chemical, physical and mechanical nature occurring in the cellular microenvironment. The interstitial flow (IF) can generate mechanical stimuli in cells that influence the cell behavior and interactions of the cells with the extracellular matrix (ECM). One of the phenomena is upstream migration, which is observed in some tumors. In this work, we present a new approach to study the adherent cell migration in a porous medium using a mechanobiological model, attempting to understand if upstream migration can be generated exclusively by mechanical factors. The influence of IF on the behavior of cells and the extracellular matrix was considered. The model is based on a system of coupled nonlinear differential equations solved by the finite element method. Several simulations were performed to study the upstream cell migration and evaluate the effects of pressure, permeability, ECM stiffness and cellular concentration variations on the cell velocity. The results indicated that upstream migration can occur in the presence of mechanical stimuli generated by IF and that the tested parameters have a direct influence on the cellular velocity, especially the pressure and the permeability. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10237-020-01289-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1537 Subjects: – SubjectFull: Cell migration Type: general – SubjectFull: Nonlinear differential equations Type: general – SubjectFull: Finite element method Type: general – SubjectFull: Extracellular matrix Type: general – SubjectFull: Human body Type: general Titles: – TitleFull: A mechanobiological model to study upstream cell migration guided by tensotaxis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rosalem, Gabriel Santos – PersonEntity: Name: NameFull: Las Casas, Estevam Barbosa – PersonEntity: Name: NameFull: Lima, Thiago Parente – PersonEntity: Name: NameFull: González-Torres, Libardo Andrés IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 16177959 Numbering: – Type: volume Value: 19 – Type: issue Value: 5 Titles: – TitleFull: Biomechanics & Modeling in Mechanobiology Type: main |
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