Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model.
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| Title: | Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model. |
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| Authors: | Novy, Zbynek1 (AUTHOR) zbynek.novy@upol.cz, Lobaz, Volodymyr2 (AUTHOR) lobaz@imc.cas.cz, Vlk, Martin3 (AUTHOR) martin.vlk@fjfi.cvut.cz, Kozempel, Jan3 (AUTHOR) jan.kozempel@fjfi.cvut.cz, Stepanek, Petr2 (AUTHOR) stepan@imc.cas.cz, Popper, Miroslav1 (AUTHOR) miroslav.popper@upol.cz, Vrbkova, Jana1 (AUTHOR) jana.vrbkova@upol.cz, Hajduch, Marian1 (AUTHOR) marian.hajduch@upol.cz, Hruby, Martin2 (AUTHOR) mhruby@centrum.cz, Petrik, Milos1 (AUTHOR) mhruby@centrum.cz |
| Source: | Nanomaterials (2079-4991). Sep2020, Vol. 10 Issue 9, p1690. 1p. |
| Subjects: | Hydroxyapatite coating, Polymers, Reticulo-endothelial system, Molecular weights, Blood circulation, Hydroxyapatite, Calcium phosphate |
| Abstract: | Nanoparticles (NPs) represent an emerging platform for diagnosis and treatment of various diseases such as cancer, where they can take advantage of enhanced permeability and retention (EPR) effect for solid tumor accumulation. To improve their colloidal stability, prolong their blood circulation time and avoid premature entrapment into reticuloendothelial system, coating with hydrophilic biocompatible polymers is often essential. Most studies, however, employ just one type of coating polymer. The main purpose of this study is to head-to-head compare biological behavior of three leading polymers commonly used as "stealth" coating materials for biocompatibilization of NPs poly(ethylene oxide), poly(2-ethyl-2-oxazoline) and poly[N-(2-hydroxypropyl)methacrylamide] in an in vivo animal solid tumor model. We used radiolabeled biodegradable hydroxyapatite NPs as a model nanoparticle core within this study and we anchored the polymers to the NPs core by hydroxybisphosphonate end groups. The general suitability of polymers for coating of NPs intended for solid tumor accumulation is that poly(2-ethyl-2-oxazoline) and poly(ethylene oxide) gave comparably similar very good results, while poly[N-(2-hydroxypropyl)methacrylamide] was significantly worse. We did not observe a strong effect of molecular weight of the coating polymers on tumor and organ accumulation, blood circulation time, biodistribution and biodegradation of the NPs. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 146143149 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Novy%2C+Zbynek%22">Novy, Zbynek</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> zbynek.novy@upol.cz</i><br /><searchLink fieldCode="AR" term="%22Lobaz%2C+Volodymyr%22">Lobaz, Volodymyr</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> lobaz@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Vlk%2C+Martin%22">Vlk, Martin</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> martin.vlk@fjfi.cvut.cz</i><br /><searchLink fieldCode="AR" term="%22Kozempel%2C+Jan%22">Kozempel, Jan</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> jan.kozempel@fjfi.cvut.cz</i><br /><searchLink fieldCode="AR" term="%22Stepanek%2C+Petr%22">Stepanek, Petr</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> stepan@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Popper%2C+Miroslav%22">Popper, Miroslav</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> miroslav.popper@upol.cz</i><br /><searchLink fieldCode="AR" term="%22Vrbkova%2C+Jana%22">Vrbkova, Jana</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> jana.vrbkova@upol.cz</i><br /><searchLink fieldCode="AR" term="%22Hajduch%2C+Marian%22">Hajduch, Marian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> marian.hajduch@upol.cz</i><br /><searchLink fieldCode="AR" term="%22Hruby%2C+Martin%22">Hruby, Martin</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> mhruby@centrum.cz</i><br /><searchLink fieldCode="AR" term="%22Petrik%2C+Milos%22">Petrik, Milos</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> mhruby@centrum.cz</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Sep2020, Vol. 10 Issue 9, p1690. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hydroxyapatite+coating%22">Hydroxyapatite coating</searchLink><br /><searchLink fieldCode="DE" term="%22Polymers%22">Polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Reticulo-endothelial+system%22">Reticulo-endothelial system</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+weights%22">Molecular weights</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+circulation%22">Blood circulation</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxyapatite%22">Hydroxyapatite</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+phosphate%22">Calcium phosphate</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Nanoparticles (NPs) represent an emerging platform for diagnosis and treatment of various diseases such as cancer, where they can take advantage of enhanced permeability and retention (EPR) effect for solid tumor accumulation. To improve their colloidal stability, prolong their blood circulation time and avoid premature entrapment into reticuloendothelial system, coating with hydrophilic biocompatible polymers is often essential. Most studies, however, employ just one type of coating polymer. The main purpose of this study is to head-to-head compare biological behavior of three leading polymers commonly used as "stealth" coating materials for biocompatibilization of NPs poly(ethylene oxide), poly(2-ethyl-2-oxazoline) and poly[N-(2-hydroxypropyl)methacrylamide] in an in vivo animal solid tumor model. We used radiolabeled biodegradable hydroxyapatite NPs as a model nanoparticle core within this study and we anchored the polymers to the NPs core by hydroxybisphosphonate end groups. The general suitability of polymers for coating of NPs intended for solid tumor accumulation is that poly(2-ethyl-2-oxazoline) and poly(ethylene oxide) gave comparably similar very good results, while poly[N-(2-hydroxypropyl)methacrylamide] was significantly worse. We did not observe a strong effect of molecular weight of the coating polymers on tumor and organ accumulation, blood circulation time, biodistribution and biodegradation of the NPs. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=146143149 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano10091690 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: 1690 Subjects: – SubjectFull: Hydroxyapatite coating Type: general – SubjectFull: Polymers Type: general – SubjectFull: Reticulo-endothelial system Type: general – SubjectFull: Molecular weights Type: general – SubjectFull: Blood circulation Type: general – SubjectFull: Hydroxyapatite Type: general – SubjectFull: Calcium phosphate Type: general Titles: – TitleFull: Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Novy, Zbynek – PersonEntity: Name: NameFull: Lobaz, Volodymyr – PersonEntity: Name: NameFull: Vlk, Martin – PersonEntity: Name: NameFull: Kozempel, Jan – PersonEntity: Name: NameFull: Stepanek, Petr – PersonEntity: Name: NameFull: Popper, Miroslav – PersonEntity: Name: NameFull: Vrbkova, Jana – PersonEntity: Name: NameFull: Hajduch, Marian – PersonEntity: Name: NameFull: Hruby, Martin – PersonEntity: Name: NameFull: Petrik, Milos IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 10 – Type: issue Value: 9 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
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