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Acidic porous carbons involved in the green and selective synthesis of benzodiazepines.

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Title: Acidic porous carbons involved in the green and selective synthesis of benzodiazepines.
Authors: Godino-Ojer, M.1 (AUTHOR), Matos, I.1,2 (AUTHOR) ines.matos@fct.unl.pt, Bernardo, M.2 (AUTHOR), Carvalho, R.3 (AUTHOR), G.P. Soares, Olívia Salomé4 (AUTHOR), Durán-Valle, C.3 (AUTHOR), Fonseca, I.M.2 (AUTHOR), Mayoral, E. Pérez1 (AUTHOR) eperez@ccia.uned.es
Source: Catalysis Today. Nov2020, Vol. 357, p64-73. 10p.
Subjects: Benzodiazepines, Catalysts, Carbon, Catalyst synthesis, Microporosity, Activated carbon
Abstract: • Acidic porous carbon efficiently catalyzes the synthesis of benzodiazepine 1. • Acid strength and porosity are key factors controlling the catalytic performance. • Total selectivity is observed by combining −SO 3 H functions and microporosity in sulfonated carbon catalyst. Eco-sustainable and recyclable porous carbons are reported as metal-free catalysts for the synthesis of benzodiazepines for the first time. The porous carbons were able to efficiently catalyse the synthesis of benzodiazepine 1 from o -phenylendiamine 2 and acetone 3 under mild conditions. Both acidic functions and the porosity of the catalysts were determinant features. High conversion values were obtained when using HNO 3 oxidized carbons. The highest selectivity to benzodiazepine 1 was obtained in the presence of the most microporous catalyst N-N, which is indicative of the great influence of porous properties. Stronger acid sites and high microporosity of the carbon treated with H 2 SO 4 yield benzodiazepine 1 with total selectivity. [ABSTRACT FROM AUTHOR]
Copyright of Catalysis Today is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: Acidic porous carbons involved in the green and selective synthesis of benzodiazepines.
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  Data: <searchLink fieldCode="JN" term="%22Catalysis+Today%22">Catalysis Today</searchLink>. Nov2020, Vol. 357, p64-73. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Benzodiazepines%22">Benzodiazepines</searchLink><br /><searchLink fieldCode="DE" term="%22Catalysts%22">Catalysts</searchLink><br /><searchLink fieldCode="DE" term="%22Carbon%22">Carbon</searchLink><br /><searchLink fieldCode="DE" term="%22Catalyst+synthesis%22">Catalyst synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Microporosity%22">Microporosity</searchLink><br /><searchLink fieldCode="DE" term="%22Activated+carbon%22">Activated carbon</searchLink>
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  Data: • Acidic porous carbon efficiently catalyzes the synthesis of benzodiazepine 1. • Acid strength and porosity are key factors controlling the catalytic performance. • Total selectivity is observed by combining −SO 3 H functions and microporosity in sulfonated carbon catalyst. Eco-sustainable and recyclable porous carbons are reported as metal-free catalysts for the synthesis of benzodiazepines for the first time. The porous carbons were able to efficiently catalyse the synthesis of benzodiazepine 1 from o -phenylendiamine 2 and acetone 3 under mild conditions. Both acidic functions and the porosity of the catalysts were determinant features. High conversion values were obtained when using HNO 3 oxidized carbons. The highest selectivity to benzodiazepine 1 was obtained in the presence of the most microporous catalyst N-N, which is indicative of the great influence of porous properties. Stronger acid sites and high microporosity of the carbon treated with H 2 SO 4 yield benzodiazepine 1 with total selectivity. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Catalysis Today is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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      – SubjectFull: Catalysts
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      – SubjectFull: Carbon
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      – SubjectFull: Catalyst synthesis
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      – SubjectFull: Microporosity
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              Text: Nov2020
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