A mechanical model of posterior vitreous detachment and generation of vitreoretinal tractions.
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| Title: | A mechanical model of posterior vitreous detachment and generation of vitreoretinal tractions. |
|---|---|
| Authors: | Di Michele, Federica1 (AUTHOR), Tatone, Amabile2 (AUTHOR), Romano, Mario R.3 (AUTHOR), Repetto, Rodolfo4 (AUTHOR) rodolfo.repetto@unige.it |
| Source: | Biomechanics & Modeling in Mechanobiology. Dec2020, Vol. 19 Issue 6, p2627-2641. 15p. |
| Subjects: | Mechanical models, Vitreous body, Vitreous humor, Focal adhesions, Retinal detachment, Retina |
| Abstract: | We propose a mechanical model of generation of vitreoretinal tractions in the presence of posterior vitreous detachment (PVD). PVD is a common occurrence with aging, and it consists in the separation of the vitreous body from the retina at the back pole of the eye, due to progressive shrinking of the vitreous gel. During this separation process, vitreoretinal tractions are generated at regions of high adhesion between the vitreous and the retina. Such tractions are mainly responsible for the creation of retinal tears, which can lead to retinal detachment. We describe the PVD evolution developing a continuum model of a shrinking soft body, representing the vitreous humor gel phase. In the model, the vitreous is surrounded by a membrane, stiffer than the bulk, the vitreous cortex, and it is contained within a rigid spherical domain, the vitreous chamber. The membrane is attached to the spherical wall and the adhesion strength is spatially non-uniform, increasing from the back to the front of the chamber, according to clinical observations. During the shrinking process, the vitreous undergoes elastic distortions, owing to the spatially variable adhesion on the wall, and this produces boundary tractions. We also consider the clinically relevant case of anomalous PVD, in which regions of focal adhesion between the vitreous and the retina exist, leading to the generation of strong, localized tractions. The model reproduces a PVD evolution in good qualitative agreement with clinical observations and makes it possible to correlate the shape of the detached vitreous with the intensity of vitreoretinal tractions. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 146754166 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A mechanical model of posterior vitreous detachment and generation of vitreoretinal tractions. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Di+Michele%2C+Federica%22">Di Michele, Federica</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tatone%2C+Amabile%22">Tatone, Amabile</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Romano%2C+Mario+R%2E%22">Romano, Mario R.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Repetto%2C+Rodolfo%22">Repetto, Rodolfo</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> rodolfo.repetto@unige.it</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Dec2020, Vol. 19 Issue 6, p2627-2641. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mechanical+models%22">Mechanical models</searchLink><br /><searchLink fieldCode="DE" term="%22Vitreous+body%22">Vitreous body</searchLink><br /><searchLink fieldCode="DE" term="%22Vitreous+humor%22">Vitreous humor</searchLink><br /><searchLink fieldCode="DE" term="%22Focal+adhesions%22">Focal adhesions</searchLink><br /><searchLink fieldCode="DE" term="%22Retinal+detachment%22">Retinal detachment</searchLink><br /><searchLink fieldCode="DE" term="%22Retina%22">Retina</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: We propose a mechanical model of generation of vitreoretinal tractions in the presence of posterior vitreous detachment (PVD). PVD is a common occurrence with aging, and it consists in the separation of the vitreous body from the retina at the back pole of the eye, due to progressive shrinking of the vitreous gel. During this separation process, vitreoretinal tractions are generated at regions of high adhesion between the vitreous and the retina. Such tractions are mainly responsible for the creation of retinal tears, which can lead to retinal detachment. We describe the PVD evolution developing a continuum model of a shrinking soft body, representing the vitreous humor gel phase. In the model, the vitreous is surrounded by a membrane, stiffer than the bulk, the vitreous cortex, and it is contained within a rigid spherical domain, the vitreous chamber. The membrane is attached to the spherical wall and the adhesion strength is spatially non-uniform, increasing from the back to the front of the chamber, according to clinical observations. During the shrinking process, the vitreous undergoes elastic distortions, owing to the spatially variable adhesion on the wall, and this produces boundary tractions. We also consider the clinically relevant case of anomalous PVD, in which regions of focal adhesion between the vitreous and the retina exist, leading to the generation of strong, localized tractions. The model reproduces a PVD evolution in good qualitative agreement with clinical observations and makes it possible to correlate the shape of the detached vitreous with the intensity of vitreoretinal tractions. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10237-020-01360-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 2627 Subjects: – SubjectFull: Mechanical models Type: general – SubjectFull: Vitreous body Type: general – SubjectFull: Vitreous humor Type: general – SubjectFull: Focal adhesions Type: general – SubjectFull: Retinal detachment Type: general – SubjectFull: Retina Type: general Titles: – TitleFull: A mechanical model of posterior vitreous detachment and generation of vitreoretinal tractions. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Di Michele, Federica – PersonEntity: Name: NameFull: Tatone, Amabile – PersonEntity: Name: NameFull: Romano, Mario R. – PersonEntity: Name: NameFull: Repetto, Rodolfo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 16177959 Numbering: – Type: volume Value: 19 – Type: issue Value: 6 Titles: – TitleFull: Biomechanics & Modeling in Mechanobiology Type: main |
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