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Sensitivity to myelin using model‐free analysis of the water resonance line‐shape in postmortem mouse brain.

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Title: Sensitivity to myelin using model‐free analysis of the water resonance line‐shape in postmortem mouse brain.
Authors: Foxley, Sean1 (AUTHOR) foxley@uchicago.edu, Wildenberg, Gregg2 (AUTHOR), Sampathkumar, Vandana2 (AUTHOR), Karczmar, Gregory S1 (AUTHOR), Brugarolas, Pedro3,4 (AUTHOR), Kasthuri, Narayanan2 (AUTHOR)
Source: Magnetic Resonance in Medicine. Feb2021, Vol. 85 Issue 2, p667-677. 11p.
Subjects: White matter (Nerve tissue), Water analysis, Echo-planar imaging, Resonance, Spectroscopic imaging
Abstract: Purpose: Dysmyelinating diseases are characterized by abnormal myelin formation and function. Such microstructural abnormalities in myelin have been demonstrated to produce measurable effects on the MR signal. This work examines these effects on measurements of voxel‐wise, high‐resolution water spectra acquired using a 3D echo‐planar spectroscopic imaging (EPSI) pulse sequence from both postmortem fixed control mouse brains and a dysmyelination mouse brain model. Methods: Perfusion fixed, resected control (n = 5) and shiverer (n = 4) mouse brains were imaged using 3D‐EPSI with 100 µm isotropic resolution. The free induction decay (FID) was sampled every 2.74 ms over 192 echoes, for a total sampling duration of 526.08 ms. Voxel‐wise FIDs were Fourier transformed to produce water spectra with 1.9 Hz resolution. Spectral asymmetry was computed and compared between the two tissue types. Results: The water resonance is more asymmetrically broadened in the white matter of control mouse brain compared with dysmyelinated white matter. In control brain, this is modulated by and consistent with previously reported orientationally dependent effects of white matter relative to B0. Similar sensitivity to orientation is observed in dysmyelinated white matter as well; however, the magnitude of the resonance asymmetry is much lower across all directions. Conclusion: Results demonstrate that components of the spectra are specifically differentially affected by myelin concentration. This suggests that water proton spectra may be sensitive to the presence of myelin, and as such, could serve as a MRI‐based biomarker of dysmyelinating disease, free of mathematical models. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Sensitivity to myelin using model‐free analysis of the water resonance line‐shape in postmortem mouse brain.
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  Data: <searchLink fieldCode="AR" term="%22Foxley%2C+Sean%22">Foxley, Sean</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> foxley@uchicago.edu</i><br /><searchLink fieldCode="AR" term="%22Wildenberg%2C+Gregg%22">Wildenberg, Gregg</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sampathkumar%2C+Vandana%22">Sampathkumar, Vandana</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Karczmar%2C+Gregory+S%22">Karczmar, Gregory S</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brugarolas%2C+Pedro%22">Brugarolas, Pedro</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kasthuri%2C+Narayanan%22">Kasthuri, Narayanan</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Feb2021, Vol. 85 Issue 2, p667-677. 11p.
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  Data: <searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Water+analysis%22">Water analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Echo-planar+imaging%22">Echo-planar imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Resonance%22">Resonance</searchLink><br /><searchLink fieldCode="DE" term="%22Spectroscopic+imaging%22">Spectroscopic imaging</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Dysmyelinating diseases are characterized by abnormal myelin formation and function. Such microstructural abnormalities in myelin have been demonstrated to produce measurable effects on the MR signal. This work examines these effects on measurements of voxel‐wise, high‐resolution water spectra acquired using a 3D echo‐planar spectroscopic imaging (EPSI) pulse sequence from both postmortem fixed control mouse brains and a dysmyelination mouse brain model. Methods: Perfusion fixed, resected control (n = 5) and shiverer (n = 4) mouse brains were imaged using 3D‐EPSI with 100 µm isotropic resolution. The free induction decay (FID) was sampled every 2.74 ms over 192 echoes, for a total sampling duration of 526.08 ms. Voxel‐wise FIDs were Fourier transformed to produce water spectra with 1.9 Hz resolution. Spectral asymmetry was computed and compared between the two tissue types. Results: The water resonance is more asymmetrically broadened in the white matter of control mouse brain compared with dysmyelinated white matter. In control brain, this is modulated by and consistent with previously reported orientationally dependent effects of white matter relative to B0. Similar sensitivity to orientation is observed in dysmyelinated white matter as well; however, the magnitude of the resonance asymmetry is much lower across all directions. Conclusion: Results demonstrate that components of the spectra are specifically differentially affected by myelin concentration. This suggests that water proton spectra may be sensitive to the presence of myelin, and as such, could serve as a MRI‐based biomarker of dysmyelinating disease, free of mathematical models. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.28440
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        Text: English
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        Type: general
      – SubjectFull: Water analysis
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      – SubjectFull: Echo-planar imaging
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      – SubjectFull: Resonance
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      – SubjectFull: Spectroscopic imaging
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    Titles:
      – TitleFull: Sensitivity to myelin using model‐free analysis of the water resonance line‐shape in postmortem mouse brain.
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            NameFull: Foxley, Sean
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              Text: Feb2021
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              Y: 2021
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