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Evaluation of fluorine‐19 magnetic resonance imaging of the lungs using octafluorocyclobutane in a rat model.

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Title: Evaluation of fluorine‐19 magnetic resonance imaging of the lungs using octafluorocyclobutane in a rat model.
Authors: Shepelytskyi, Yurii1,2 (AUTHOR), Li, Tao3 (AUTHOR), Grynko, Vira1,2 (AUTHOR), Newman, Camryn4 (AUTHOR), Hane, Francis T.2,3 (AUTHOR), Albert, Mitchell S.2,3,5 (AUTHOR) malbert1@lakeheadu.ca
Source: Magnetic Resonance in Medicine. Feb2021, Vol. 85 Issue 2, p987-994. 8p.
Subjects: Lungs, Spectral imaging, Signal-to-noise ratio, Statistical significance
Geographic Terms: Andover (Mass.)
Abstract: Purpose: To test octafluorocyclobutane (OFCB) as an inhalation contrast agent for fluorine‐19 MRI of the lung, and to compare the image quality of OFCB scans with perfluoropropane (PFP) scans Theory and Methods: After normalizing for the number of signal averages, a theoretical comparison between the OFCB signal‐to‐noise ratio (SNR) and PFP SNR predicted the average SNR advantage of 90% using OFCB during gradient echo imaging. The OFCB relaxometry was conducted using single‐voxel spectroscopy and spin‐echo imaging. A comparison of OFCB and PFP SNRs was performed in vitro and in vivo. Five healthy Sprague‐Dawley rats were imaged during single breath‐hold and continuous breathing using a Philips Achieva 3.0T MRI scanner (Philips, Andover, MA). The scan time was constant for both gases. Statistical comparison between PFP and OFCB scans was conducted using a paired t test and by calculating the Bayes factor. Results: Spin‐lattice (T1) and effective spin‐spin (T2∗) relaxation time constants of the pure OFCB gas were determined as 28.5 ± 1.2 ms and 10.5 ± 1.8 ms, respectively. Mixing with 21% of oxygen decreased T1 by 30% and T2∗ by 20%. The OFCB in vivo images showed 73% higher normalized SNR on average compared with images acquired using PFP. The statistical significance was shown by both paired t test and calculated Bayes factors. The experimental results agree with theoretical calculations within the error of the relaxation parameter measurements. Conclusion: The quality of the lung images acquired using OFCB was significantly better compared with PFP scans. The OFCB images had higher a SNR and were artifact‐free. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Evaluation of fluorine‐19 magnetic resonance imaging of the lungs using octafluorocyclobutane in a rat model.
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  Data: <searchLink fieldCode="AR" term="%22Shepelytskyi%2C+Yurii%22">Shepelytskyi, Yurii</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Tao%22">Li, Tao</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grynko%2C+Vira%22">Grynko, Vira</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Newman%2C+Camryn%22">Newman, Camryn</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hane%2C+Francis+T%2E%22">Hane, Francis T.</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Albert%2C+Mitchell+S%2E%22">Albert, Mitchell S.</searchLink><relatesTo>2,3,5</relatesTo> (AUTHOR)<i> malbert1@lakeheadu.ca</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Feb2021, Vol. 85 Issue 2, p987-994. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Lungs%22">Lungs</searchLink><br /><searchLink fieldCode="DE" term="%22Spectral+imaging%22">Spectral imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Signal-to-noise+ratio%22">Signal-to-noise ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+significance%22">Statistical significance</searchLink>
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  Label: Abstract
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  Data: Purpose: To test octafluorocyclobutane (OFCB) as an inhalation contrast agent for fluorine‐19 MRI of the lung, and to compare the image quality of OFCB scans with perfluoropropane (PFP) scans Theory and Methods: After normalizing for the number of signal averages, a theoretical comparison between the OFCB signal‐to‐noise ratio (SNR) and PFP SNR predicted the average SNR advantage of 90% using OFCB during gradient echo imaging. The OFCB relaxometry was conducted using single‐voxel spectroscopy and spin‐echo imaging. A comparison of OFCB and PFP SNRs was performed in vitro and in vivo. Five healthy Sprague‐Dawley rats were imaged during single breath‐hold and continuous breathing using a Philips Achieva 3.0T MRI scanner (Philips, Andover, MA). The scan time was constant for both gases. Statistical comparison between PFP and OFCB scans was conducted using a paired t test and by calculating the Bayes factor. Results: Spin‐lattice (T1) and effective spin‐spin (T2∗) relaxation time constants of the pure OFCB gas were determined as 28.5 ± 1.2 ms and 10.5 ± 1.8 ms, respectively. Mixing with 21% of oxygen decreased T1 by 30% and T2∗ by 20%. The OFCB in vivo images showed 73% higher normalized SNR on average compared with images acquired using PFP. The statistical significance was shown by both paired t test and calculated Bayes factors. The experimental results agree with theoretical calculations within the error of the relaxation parameter measurements. Conclusion: The quality of the lung images acquired using OFCB was significantly better compared with PFP scans. The OFCB images had higher a SNR and were artifact‐free. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Signal-to-noise ratio
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      – SubjectFull: Statistical significance
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      – SubjectFull: Andover (Mass.)
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      – TitleFull: Evaluation of fluorine‐19 magnetic resonance imaging of the lungs using octafluorocyclobutane in a rat model.
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            NameFull: Shepelytskyi, Yurii
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              Text: Feb2021
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