Evaluation of fluorine‐19 magnetic resonance imaging of the lungs using octafluorocyclobutane in a rat model.
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| Title: | Evaluation of fluorine‐19 magnetic resonance imaging of the lungs using octafluorocyclobutane in a rat model. |
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| Authors: | Shepelytskyi, Yurii1,2 (AUTHOR), Li, Tao3 (AUTHOR), Grynko, Vira1,2 (AUTHOR), Newman, Camryn4 (AUTHOR), Hane, Francis T.2,3 (AUTHOR), Albert, Mitchell S.2,3,5 (AUTHOR) malbert1@lakeheadu.ca |
| Source: | Magnetic Resonance in Medicine. Feb2021, Vol. 85 Issue 2, p987-994. 8p. |
| Subjects: | Lungs, Spectral imaging, Signal-to-noise ratio, Statistical significance |
| Geographic Terms: | Andover (Mass.) |
| Abstract: | Purpose: To test octafluorocyclobutane (OFCB) as an inhalation contrast agent for fluorine‐19 MRI of the lung, and to compare the image quality of OFCB scans with perfluoropropane (PFP) scans Theory and Methods: After normalizing for the number of signal averages, a theoretical comparison between the OFCB signal‐to‐noise ratio (SNR) and PFP SNR predicted the average SNR advantage of 90% using OFCB during gradient echo imaging. The OFCB relaxometry was conducted using single‐voxel spectroscopy and spin‐echo imaging. A comparison of OFCB and PFP SNRs was performed in vitro and in vivo. Five healthy Sprague‐Dawley rats were imaged during single breath‐hold and continuous breathing using a Philips Achieva 3.0T MRI scanner (Philips, Andover, MA). The scan time was constant for both gases. Statistical comparison between PFP and OFCB scans was conducted using a paired t test and by calculating the Bayes factor. Results: Spin‐lattice (T1) and effective spin‐spin (T2∗) relaxation time constants of the pure OFCB gas were determined as 28.5 ± 1.2 ms and 10.5 ± 1.8 ms, respectively. Mixing with 21% of oxygen decreased T1 by 30% and T2∗ by 20%. The OFCB in vivo images showed 73% higher normalized SNR on average compared with images acquired using PFP. The statistical significance was shown by both paired t test and calculated Bayes factors. The experimental results agree with theoretical calculations within the error of the relaxation parameter measurements. Conclusion: The quality of the lung images acquired using OFCB was significantly better compared with PFP scans. The OFCB images had higher a SNR and were artifact‐free. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Purpose: To test octafluorocyclobutane (OFCB) as an inhalation contrast agent for fluorine‐19 MRI of the lung, and to compare the image quality of OFCB scans with perfluoropropane (PFP) scans Theory and Methods: After normalizing for the number of signal averages, a theoretical comparison between the OFCB signal‐to‐noise ratio (SNR) and PFP SNR predicted the average SNR advantage of 90% using OFCB during gradient echo imaging. The OFCB relaxometry was conducted using single‐voxel spectroscopy and spin‐echo imaging. A comparison of OFCB and PFP SNRs was performed in vitro and in vivo. Five healthy Sprague‐Dawley rats were imaged during single breath‐hold and continuous breathing using a Philips Achieva 3.0T MRI scanner (Philips, Andover, MA). The scan time was constant for both gases. Statistical comparison between PFP and OFCB scans was conducted using a paired t test and by calculating the Bayes factor. Results: Spin‐lattice (T1) and effective spin‐spin (T2∗) relaxation time constants of the pure OFCB gas were determined as 28.5 ± 1.2 ms and 10.5 ± 1.8 ms, respectively. Mixing with 21% of oxygen decreased T1 by 30% and T2∗ by 20%. The OFCB in vivo images showed 73% higher normalized SNR on average compared with images acquired using PFP. The statistical significance was shown by both paired t test and calculated Bayes factors. The experimental results agree with theoretical calculations within the error of the relaxation parameter measurements. Conclusion: The quality of the lung images acquired using OFCB was significantly better compared with PFP scans. The OFCB images had higher a SNR and were artifact‐free. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 07403194 |
| DOI: | 10.1002/mrm.28473 |
