Combination of biocompatible hydrogel precursors to apatitic calcium phosphate cements (CPCs): Influence of the in situ hydrogel reticulation on the CPC properties.
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| Title: | Combination of biocompatible hydrogel precursors to apatitic calcium phosphate cements (CPCs): Influence of the in situ hydrogel reticulation on the CPC properties. |
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| Authors: | Ramirez Caballero, Silvia Stella1 (AUTHOR), Ferri‐Angulo, Daniel2 (AUTHOR), Debret, Romain3 (AUTHOR), Granier, Fabien4 (AUTHOR), Marie, Sébastien4 (AUTHOR), Lefèvre, François‐Xavier5 (AUTHOR), Bouler, Jean‐Michel5 (AUTHOR), Despas, Christelle6 (AUTHOR), Sohier, Jérôme2 (AUTHOR), Bujoli, Bruno5 (AUTHOR) bruno.bujoli@univ-nantes.fr |
| Source: | Journal of Biomedical Materials Research, Part B: Applied Biomaterials. Jan2021, Vol. 109 Issue 1, p102-116. 15p. |
| Subjects: | Calcium phosphate, Cement, Bones, Regenerative medicine, Hyaluronic acid |
| Abstract: | In the field of bone regenerative medicine, injectable calcium phosphate cements (CPCs) are used for decades in clinics, as bone void fillers. Most often preformed polymers (e.g., hyaluronic acid, collagen, chitosan, cellulose ethers...) are introduced in the CPC formulation to make it injectable and improve its cohesion. Once the cement has hardened, the polymer is simply trapped in the CPC structure and no organic subnetwork is present. By contrast, in this work a CPC was combined with organic monomers that reticulated in situ so that a continuous biocompatible 3D polymeric subnetwork was formed in the CPC microstructure, resulting in a higher permeability of the CPC, which might allow to accelerate its in vivo degradation. Two options were investigated depending on whether the polymer was formed before the apatitic inorganic network or concomitantly. In the former case, conditions were found to reach a suitable rheology for easy injection of the composite. In addition, the in situ formed polymer was shown to strongly affect the size, density, and arrangement of the apatite crystals formed during the setting reaction, thereby offering an original route to modulate the microstructure and porosity of apatitic cements. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Biomedical Materials Research, Part B: Applied Biomaterials is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 147105918 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Combination of biocompatible hydrogel precursors to apatitic calcium phosphate cements (CPCs): Influence of the in situ hydrogel reticulation on the CPC properties. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ramirez+Caballero%2C+Silvia+Stella%22">Ramirez Caballero, Silvia Stella</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferri‐Angulo%2C+Daniel%22">Ferri‐Angulo, Daniel</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Debret%2C+Romain%22">Debret, Romain</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Granier%2C+Fabien%22">Granier, Fabien</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marie%2C+Sébastien%22">Marie, Sébastien</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lefèvre%2C+François‐Xavier%22">Lefèvre, François‐Xavier</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bouler%2C+Jean‐Michel%22">Bouler, Jean‐Michel</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Despas%2C+Christelle%22">Despas, Christelle</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sohier%2C+Jérôme%22">Sohier, Jérôme</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bujoli%2C+Bruno%22">Bujoli, Bruno</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> bruno.bujoli@univ-nantes.fr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials%22">Journal of Biomedical Materials Research, Part B: Applied Biomaterials</searchLink>. Jan2021, Vol. 109 Issue 1, p102-116. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Calcium+phosphate%22">Calcium phosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Cement%22">Cement</searchLink><br /><searchLink fieldCode="DE" term="%22Bones%22">Bones</searchLink><br /><searchLink fieldCode="DE" term="%22Regenerative+medicine%22">Regenerative medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Hyaluronic+acid%22">Hyaluronic acid</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In the field of bone regenerative medicine, injectable calcium phosphate cements (CPCs) are used for decades in clinics, as bone void fillers. Most often preformed polymers (e.g., hyaluronic acid, collagen, chitosan, cellulose ethers...) are introduced in the CPC formulation to make it injectable and improve its cohesion. Once the cement has hardened, the polymer is simply trapped in the CPC structure and no organic subnetwork is present. By contrast, in this work a CPC was combined with organic monomers that reticulated in situ so that a continuous biocompatible 3D polymeric subnetwork was formed in the CPC microstructure, resulting in a higher permeability of the CPC, which might allow to accelerate its in vivo degradation. Two options were investigated depending on whether the polymer was formed before the apatitic inorganic network or concomitantly. In the former case, conditions were found to reach a suitable rheology for easy injection of the composite. In addition, the in situ formed polymer was shown to strongly affect the size, density, and arrangement of the apatite crystals formed during the setting reaction, thereby offering an original route to modulate the microstructure and porosity of apatitic cements. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Biomedical Materials Research, Part B: Applied Biomaterials is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/jbm.b.34685 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 102 Subjects: – SubjectFull: Calcium phosphate Type: general – SubjectFull: Cement Type: general – SubjectFull: Bones Type: general – SubjectFull: Regenerative medicine Type: general – SubjectFull: Hyaluronic acid Type: general Titles: – TitleFull: Combination of biocompatible hydrogel precursors to apatitic calcium phosphate cements (CPCs): Influence of the in situ hydrogel reticulation on the CPC properties. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ramirez Caballero, Silvia Stella – PersonEntity: Name: NameFull: Ferri‐Angulo, Daniel – PersonEntity: Name: NameFull: Debret, Romain – PersonEntity: Name: NameFull: Granier, Fabien – PersonEntity: Name: NameFull: Marie, Sébastien – PersonEntity: Name: NameFull: Lefèvre, François‐Xavier – PersonEntity: Name: NameFull: Bouler, Jean‐Michel – PersonEntity: Name: NameFull: Despas, Christelle – PersonEntity: Name: NameFull: Sohier, Jérôme – PersonEntity: Name: NameFull: Bujoli, Bruno IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 15524973 Numbering: – Type: volume Value: 109 – Type: issue Value: 1 Titles: – TitleFull: Journal of Biomedical Materials Research, Part B: Applied Biomaterials Type: main |
| ResultId | 1 |
