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Nipah virus dynamics in bats and implications for spillover to humans.

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Title: Nipah virus dynamics in bats and implications for spillover to humans.
Authors: Epstein, Jonathan H.1 epstein@ecohealthalliance.org, Anthony, Simon J.2,3, Islam, Ariful1, Kilpatrick, A. Marm4, Khan, Shahneaz Ali1,5, Balkey, Maria D.2,6, Ross, Noam1, Smith, Ina7, Zambrana-Torrelio, Carlos1, Yun Tao1, Islam, Ausraful8, Phenix Lan Quan2, Olival, Kevin J.1, Khan, M. Salah Uddin8, Gurley, Emily S.8,9, Hossein, M. Jahangir10, Field, Hume E.1, Fielder, Mark D.11, Briese, Thomas2, Rahman, Mahmudur12
Source: Proceedings of the National Academy of Sciences of the United States of America. 11/17/2020, Vol. 117 Issue 46, p29190-29201. 12p.
Subjects: Nipah virus, Bats, Viral genetics, Molecular epidemiology, Humoral immunity
Geographic Terms: Bangladesh, South Asia
Abstract: Nipah virus (NiV) is an emerging bat-borne zoonotic virus that causes near-annual outbreaks of fatal encephalitis in South Asia-- one of the most populous regions on Earth. In Bangladesh, infection occurs when people drink date-palm sap contaminated with bat excreta. Outbreaks are sporadic, and the influence of viral dynamics in bats on their temporal and spatial distribution is poorly understood. We analyzed data on host ecology, molecular epidemiology, serological dynamics, and viral genetics to characterize spatiotemporal patterns of NiV dynamics in its wildlife reservoir, Pteropus medius bats, in Bangladesh. We found that NiV transmission occurred throughout the country and throughout the year. Model results indicated that local transmission dynamics were modulated by density-dependent transmission, acquired immunity that is lost over time, and recrudescence. Increased transmission followed multiyear periods of declining seroprevalence due to batpopulation turnover and individual loss of humoral immunity. Individual bats had smaller host ranges than other Pteropus species (spp.), although movement data and the discovery of a Malaysiaclade NiV strain in eastern Bangladesh suggest connectivity with bats east of Bangladesh. These data suggest that discrete multiannual local epizootics in bat populations contribute to the sporadic nature of NiV outbreaks in South Asia. At the same time, the broad spatial and temporal extent of NiV transmission, including the recent outbreak in Kerala, India, highlights the continued risk of spillover to humans wherever they may interact with pteropid bats and the importance of limiting opportunities for spillover throughout Pteropus's range. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: Nipah virus dynamics in bats and implications for spillover to humans.
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  Data: <searchLink fieldCode="AR" term="%22Epstein%2C+Jonathan+H%2E%22">Epstein, Jonathan H.</searchLink><relatesTo>1</relatesTo><i> epstein@ecohealthalliance.org</i><br /><searchLink fieldCode="AR" term="%22Anthony%2C+Simon+J%2E%22">Anthony, Simon J.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Islam%2C+Ariful%22">Islam, Ariful</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kilpatrick%2C+A%2E+Marm%22">Kilpatrick, A. Marm</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Khan%2C+Shahneaz+Ali%22">Khan, Shahneaz Ali</searchLink><relatesTo>1,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Balkey%2C+Maria+D%2E%22">Balkey, Maria D.</searchLink><relatesTo>2,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Ross%2C+Noam%22">Ross, Noam</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Smith%2C+Ina%22">Smith, Ina</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Zambrana-Torrelio%2C+Carlos%22">Zambrana-Torrelio, Carlos</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yun+Tao%22">Yun Tao</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Islam%2C+Ausraful%22">Islam, Ausraful</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Phenix+Lan+Quan%22">Phenix Lan Quan</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Olival%2C+Kevin+J%2E%22">Olival, Kevin J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Khan%2C+M%2E+Salah+Uddin%22">Khan, M. Salah Uddin</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Gurley%2C+Emily+S%2E%22">Gurley, Emily S.</searchLink><relatesTo>8,9</relatesTo><br /><searchLink fieldCode="AR" term="%22Hossein%2C+M%2E+Jahangir%22">Hossein, M. Jahangir</searchLink><relatesTo>10</relatesTo><br /><searchLink fieldCode="AR" term="%22Field%2C+Hume+E%2E%22">Field, Hume E.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Fielder%2C+Mark+D%2E%22">Fielder, Mark D.</searchLink><relatesTo>11</relatesTo><br /><searchLink fieldCode="AR" term="%22Briese%2C+Thomas%22">Briese, Thomas</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Rahman%2C+Mahmudur%22">Rahman, Mahmudur</searchLink><relatesTo>12</relatesTo>
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  Data: <searchLink fieldCode="DE" term="%22Nipah+virus%22">Nipah virus</searchLink><br /><searchLink fieldCode="DE" term="%22Bats%22">Bats</searchLink><br /><searchLink fieldCode="DE" term="%22Viral+genetics%22">Viral genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+epidemiology%22">Molecular epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Humoral+immunity%22">Humoral immunity</searchLink>
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  Data: Nipah virus (NiV) is an emerging bat-borne zoonotic virus that causes near-annual outbreaks of fatal encephalitis in South Asia-- one of the most populous regions on Earth. In Bangladesh, infection occurs when people drink date-palm sap contaminated with bat excreta. Outbreaks are sporadic, and the influence of viral dynamics in bats on their temporal and spatial distribution is poorly understood. We analyzed data on host ecology, molecular epidemiology, serological dynamics, and viral genetics to characterize spatiotemporal patterns of NiV dynamics in its wildlife reservoir, Pteropus medius bats, in Bangladesh. We found that NiV transmission occurred throughout the country and throughout the year. Model results indicated that local transmission dynamics were modulated by density-dependent transmission, acquired immunity that is lost over time, and recrudescence. Increased transmission followed multiyear periods of declining seroprevalence due to batpopulation turnover and individual loss of humoral immunity. Individual bats had smaller host ranges than other Pteropus species (spp.), although movement data and the discovery of a Malaysiaclade NiV strain in eastern Bangladesh suggest connectivity with bats east of Bangladesh. These data suggest that discrete multiannual local epizootics in bat populations contribute to the sporadic nature of NiV outbreaks in South Asia. At the same time, the broad spatial and temporal extent of NiV transmission, including the recent outbreak in Kerala, India, highlights the continued risk of spillover to humans wherever they may interact with pteropid bats and the importance of limiting opportunities for spillover throughout Pteropus's range. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1073/pnas.2000429117
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        Text: English
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      – SubjectFull: Nipah virus
        Type: general
      – SubjectFull: Bats
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      – SubjectFull: Viral genetics
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      – SubjectFull: Molecular epidemiology
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      – SubjectFull: Humoral immunity
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      – SubjectFull: Bangladesh
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      – SubjectFull: South Asia
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