Solution combustion synthesis (SCS) of theranostic ions doped biphasic calcium phosphates; kinetic of ions release in simulated body fluid (SBF) and reactive oxygen species (ROS) generation.
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| Title: | Solution combustion synthesis (SCS) of theranostic ions doped biphasic calcium phosphates; kinetic of ions release in simulated body fluid (SBF) and reactive oxygen species (ROS) generation. |
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| Authors: | Kermani, F.1 (AUTHOR), Mollazadeh, S.1 (AUTHOR) Mollazadeh.b@um.ac.ir, Kargozar, S.1,2 (AUTHOR) Kargozarsaeid@gmail.com, Vahdati Khakhi, J.1 (AUTHOR) |
| Source: | Materials Science & Engineering: C. Jan2021, Vol. 118, pN.PAG-N.PAG. 1p. |
| Subjects: | Reactive oxygen species, Self-propagating high-temperature synthesis, Calcium phosphate, Body fluids, Ions, Surface charges |
| Abstract: | Theranostic ions offer suitable platforms for cancer theranostics; here, the effect of doping various amounts of theranostic ions (i.e., Sr2+, Fe2+, and Ti4+ ions) on the physicochemical properties and biological activities of calcium phosphates (CaPs) were investigated. The solution combustion synthesis (SCS) was conducted at different amounts of ions (i.e., = 0.1, 0.25, 0.5 mol). Desirable physicochemical properties were obtained in doped samples with 0.1 mol of ions. The particle size of the Sr, Fe, and Ti-doped samples was decreased from 68 to 39, 24, and 29 nm, respectively. The surface charge of the mentioned samples was changed from −20 to −24, −28, and −25 mV, respectively. Besides, the specific surface area of the mentioned samples was significantly increased from 38 to 79, 65, and 106 m2/g, respectively. It was found that bioactivity of doped CaPs improved ~95%, which relied on the high adsorption and desorption rate of Ca2+ ions in the simulated body fluid (SBF). The in vitro cell-based results demonstrate the potent effect of CaPs and theranostic ions doped CaPs on the reactive oxygen species (ROS) generation. In the presence of CaPs, the intracellular ROS generation is increased by about 60%. Besides, the intracellular ROS generation is improved in Sr2+, Fe2+, and Ti4+ ions doped CaPs by about 66, 64, and 68%. As a result of the high generation of ROS, the bone nodule formation of cell treated CaPs and theranostic ions doped CaPs is improved 25%–37%. Finally, it can be concluded that the use of the SCS approaches for doping of theranostic ions causes well-physicochemical properties and high biological activities. Unlabelled Image • The theranostic ions doping in CaPs leads to the well-physicochemical properties. • The release kinetic of ions in the simulated body fluid was explored. • The effect of CaPs and theranostic ions doped CaPs on the ROS generation were investigated. • The theranostic ions doping improved the bioactivity and in vitro biological properties of CaPs. [ABSTRACT FROM AUTHOR] |
| Copyright of Materials Science & Engineering: C is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 147182605 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Solution combustion synthesis (SCS) of theranostic ions doped biphasic calcium phosphates; kinetic of ions release in simulated body fluid (SBF) and reactive oxygen species (ROS) generation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kermani%2C+F%2E%22">Kermani, F.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mollazadeh%2C+S%2E%22">Mollazadeh, S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> Mollazadeh.b@um.ac.ir</i><br /><searchLink fieldCode="AR" term="%22Kargozar%2C+S%2E%22">Kargozar, S.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> Kargozarsaeid@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Vahdati+Khakhi%2C+J%2E%22">Vahdati Khakhi, J.</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Materials+Science+%26+Engineering%3A+C%22">Materials Science & Engineering: C</searchLink>. Jan2021, Vol. 118, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22Self-propagating+high-temperature+synthesis%22">Self-propagating high-temperature synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+phosphate%22">Calcium phosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Body+fluids%22">Body fluids</searchLink><br /><searchLink fieldCode="DE" term="%22Ions%22">Ions</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+charges%22">Surface charges</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Theranostic ions offer suitable platforms for cancer theranostics; here, the effect of doping various amounts of theranostic ions (i.e., Sr2+, Fe2+, and Ti4+ ions) on the physicochemical properties and biological activities of calcium phosphates (CaPs) were investigated. The solution combustion synthesis (SCS) was conducted at different amounts of ions (i.e., = 0.1, 0.25, 0.5 mol). Desirable physicochemical properties were obtained in doped samples with 0.1 mol of ions. The particle size of the Sr, Fe, and Ti-doped samples was decreased from 68 to 39, 24, and 29 nm, respectively. The surface charge of the mentioned samples was changed from −20 to −24, −28, and −25 mV, respectively. Besides, the specific surface area of the mentioned samples was significantly increased from 38 to 79, 65, and 106 m2/g, respectively. It was found that bioactivity of doped CaPs improved ~95%, which relied on the high adsorption and desorption rate of Ca2+ ions in the simulated body fluid (SBF). The in vitro cell-based results demonstrate the potent effect of CaPs and theranostic ions doped CaPs on the reactive oxygen species (ROS) generation. In the presence of CaPs, the intracellular ROS generation is increased by about 60%. Besides, the intracellular ROS generation is improved in Sr2+, Fe2+, and Ti4+ ions doped CaPs by about 66, 64, and 68%. As a result of the high generation of ROS, the bone nodule formation of cell treated CaPs and theranostic ions doped CaPs is improved 25%–37%. Finally, it can be concluded that the use of the SCS approaches for doping of theranostic ions causes well-physicochemical properties and high biological activities. Unlabelled Image • The theranostic ions doping in CaPs leads to the well-physicochemical properties. • The release kinetic of ions in the simulated body fluid was explored. • The effect of CaPs and theranostic ions doped CaPs on the ROS generation were investigated. • The theranostic ions doping improved the bioactivity and in vitro biological properties of CaPs. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Materials Science & Engineering: C is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.msec.2020.111533 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Reactive oxygen species Type: general – SubjectFull: Self-propagating high-temperature synthesis Type: general – SubjectFull: Calcium phosphate Type: general – SubjectFull: Body fluids Type: general – SubjectFull: Ions Type: general – SubjectFull: Surface charges Type: general Titles: – TitleFull: Solution combustion synthesis (SCS) of theranostic ions doped biphasic calcium phosphates; kinetic of ions release in simulated body fluid (SBF) and reactive oxygen species (ROS) generation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kermani, F. – PersonEntity: Name: NameFull: Mollazadeh, S. – PersonEntity: Name: NameFull: Kargozar, S. – PersonEntity: Name: NameFull: Vahdati Khakhi, J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 09284931 Numbering: – Type: volume Value: 118 Titles: – TitleFull: Materials Science & Engineering: C Type: main |
| ResultId | 1 |
