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Lipidic Cubic-Phase Nanoparticles (Cubosomes) Loaded with Doxorubicin and Labeled with 177 Lu as a Potential Tool for Combined Chemo and Internal Radiotherapy for Cancers.

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Title: Lipidic Cubic-Phase Nanoparticles (Cubosomes) Loaded with Doxorubicin and Labeled with 177 Lu as a Potential Tool for Combined Chemo and Internal Radiotherapy for Cancers.
Authors: Cytryniak, Adrianna1 (AUTHOR) acytryniak@chem.uw.edu.pl, Nazaruk, Ewa1 (AUTHOR) enaz@chem.uw.edu.pl, Bilewicz, Renata1 (AUTHOR) bilewicz@chem.uw.edu.pl, Górzyńska, Emilia2 (AUTHOR) e.gorzynska@student.uw.edu.pl, Żelechowska-Matysiak, Kinga2 (AUTHOR) k.zelechowska@ichtj.waw.pl, Walczak, Rafał2 (AUTHOR) r.walczak@ichtj.waw.pl, Mames, Adam3 (AUTHOR) amames@ichf.edu.pl, Bilewicz, Aleksander2 (AUTHOR) a.bilewicz@ichtj.waw.pl, Majkowska-Pilip, Agnieszka2 (AUTHOR) a.majkowska@ichtj.waw.pl
Source: Nanomaterials (2079-4991). Nov2020, Vol. 10 Issue 11, p2272-2272. 1p.
Subjects: Doxorubicin, Cancer radiotherapy, Drug delivery systems, Antineoplastic agents, HeLa cells, Nanoparticles
Abstract: Lipid liquid-crystalline nanoparticles (cubosomes) were used for the first time as a dual-modality drug delivery system for internal radiotherapy combined with chemotherapy. Monoolein (GMO)-based cubosomes were prepared by loading the anticancer drug, doxorubicin and a commonly used radionuclide, low-energy beta (β−)-emitter, 177Lu. The radionuclide was complexed with a long chain derivative of DOTAGA (DOTAGA-OA). The DOTAGA headgroup of the chelator was exposed to the aqueous channels of the cubosomes, while, concerning OA, the hydrophobic tail was embedded in the nonpolar region of the lipid bilayer matrix, placing the radioactive dopant in a stable manner inside the cubosome. The cubosomes containing doxorubicin and the radionuclide complex increased the cytotoxicity measured by the viability of the treated HeLa cells compared with the effect of single-drug cubosomes containing either the DOX DOTAGA-OA or DOTAGA-OA-177Lu complex. Multifunctional lipidic nanoparticles encapsulating the chemotherapeutic agent together with appropriately complexed (β−) radionuclide are proposed as a potential strategy for effective local therapy of various cancers. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Lipidic Cubic-Phase Nanoparticles (Cubosomes) Loaded with Doxorubicin and Labeled with 177 Lu as a Potential Tool for Combined Chemo and Internal Radiotherapy for Cancers.
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  Data: <searchLink fieldCode="AR" term="%22Cytryniak%2C+Adrianna%22">Cytryniak, Adrianna</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> acytryniak@chem.uw.edu.pl</i><br /><searchLink fieldCode="AR" term="%22Nazaruk%2C+Ewa%22">Nazaruk, Ewa</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> enaz@chem.uw.edu.pl</i><br /><searchLink fieldCode="AR" term="%22Bilewicz%2C+Renata%22">Bilewicz, Renata</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> bilewicz@chem.uw.edu.pl</i><br /><searchLink fieldCode="AR" term="%22Górzyńska%2C+Emilia%22">Górzyńska, Emilia</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> e.gorzynska@student.uw.edu.pl</i><br /><searchLink fieldCode="AR" term="%22Żelechowska-Matysiak%2C+Kinga%22">Żelechowska-Matysiak, Kinga</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> k.zelechowska@ichtj.waw.pl</i><br /><searchLink fieldCode="AR" term="%22Walczak%2C+Rafał%22">Walczak, Rafał</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> r.walczak@ichtj.waw.pl</i><br /><searchLink fieldCode="AR" term="%22Mames%2C+Adam%22">Mames, Adam</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> amames@ichf.edu.pl</i><br /><searchLink fieldCode="AR" term="%22Bilewicz%2C+Aleksander%22">Bilewicz, Aleksander</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> a.bilewicz@ichtj.waw.pl</i><br /><searchLink fieldCode="AR" term="%22Majkowska-Pilip%2C+Agnieszka%22">Majkowska-Pilip, Agnieszka</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> a.majkowska@ichtj.waw.pl</i>
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Nov2020, Vol. 10 Issue 11, p2272-2272. 1p.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Doxorubicin%22">Doxorubicin</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+radiotherapy%22">Cancer radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22HeLa+cells%22">HeLa cells</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Lipid liquid-crystalline nanoparticles (cubosomes) were used for the first time as a dual-modality drug delivery system for internal radiotherapy combined with chemotherapy. Monoolein (GMO)-based cubosomes were prepared by loading the anticancer drug, doxorubicin and a commonly used radionuclide, low-energy beta (β−)-emitter, 177Lu. The radionuclide was complexed with a long chain derivative of DOTAGA (DOTAGA-OA). The DOTAGA headgroup of the chelator was exposed to the aqueous channels of the cubosomes, while, concerning OA, the hydrophobic tail was embedded in the nonpolar region of the lipid bilayer matrix, placing the radioactive dopant in a stable manner inside the cubosome. The cubosomes containing doxorubicin and the radionuclide complex increased the cytotoxicity measured by the viability of the treated HeLa cells compared with the effect of single-drug cubosomes containing either the DOX DOTAGA-OA or DOTAGA-OA-177Lu complex. Multifunctional lipidic nanoparticles encapsulating the chemotherapeutic agent together with appropriately complexed (β−) radionuclide are proposed as a potential strategy for effective local therapy of various cancers. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano10112272
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: 2272
    Subjects:
      – SubjectFull: Doxorubicin
        Type: general
      – SubjectFull: Cancer radiotherapy
        Type: general
      – SubjectFull: Drug delivery systems
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      – SubjectFull: Antineoplastic agents
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      – SubjectFull: HeLa cells
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      – SubjectFull: Nanoparticles
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    Titles:
      – TitleFull: Lipidic Cubic-Phase Nanoparticles (Cubosomes) Loaded with Doxorubicin and Labeled with 177 Lu as a Potential Tool for Combined Chemo and Internal Radiotherapy for Cancers.
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              Text: Nov2020
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