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Recent advances in the role of sphingosine 1‐phosphate in cancer.

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Title: Recent advances in the role of sphingosine 1‐phosphate in cancer.
Authors: Pyne, Nigel J.1 (AUTHOR), Pyne, Susan1 (AUTHOR) susan.pyne@strath.ac.uk
Source: FEBS Letters. Nov2020, Vol. 594 Issue 22, p3583-3601. 19p.
Subjects: Sphingosine kinase, G protein coupled receptors, Sphingosine
Abstract: Sphingosine 1‐phosphate (S1P) is a bioactive lipid that binds to a family of G protein‐coupled receptors (S1P1–5) and intracellular targets, such as HDAC1/2, that are functional in normal and pathophysiologic cell biology. There is a significant role for sphingosine 1‐phosphate in cancer underpinning the so‐called hallmarks, such as transformation and replicative immortality. In this review, we survey the most recent developments concerning the role of sphingosine 1‐phosphate receptors, sphingosine kinase and S1P lyase in cancer and the prognostic indications of these receptors and enzymes in terms of disease‐specific survival and recurrence. We also provide evidence for identification of new therapeutic approaches targeting sphingosine 1‐phosphate to prevent neovascularisation, to revert aggressive and drug‐resistant cancers to more amenable forms sensitive to chemotherapy, and to induce cytotoxicity in cancer cells. Finally, we briefly describe current advances in the development of isoform‐specific inhibitors of sphingosine kinases for potential use in the treatment of various cancers, where these enzymes have a predominant role. This review will therefore highlight sphingosine 1‐phosphate signalling as a promising translational target for precision medicine in stratified cancer patients. [ABSTRACT FROM AUTHOR]
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: Recent advances in the role of sphingosine 1‐phosphate in cancer.
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  Data: <searchLink fieldCode="AR" term="%22Pyne%2C+Nigel+J%2E%22">Pyne, Nigel J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pyne%2C+Susan%22">Pyne, Susan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> susan.pyne@strath.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22FEBS+Letters%22">FEBS Letters</searchLink>. Nov2020, Vol. 594 Issue 22, p3583-3601. 19p.
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  Data: <searchLink fieldCode="DE" term="%22Sphingosine+kinase%22">Sphingosine kinase</searchLink><br /><searchLink fieldCode="DE" term="%22G+protein+coupled+receptors%22">G protein coupled receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Sphingosine%22">Sphingosine</searchLink>
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  Label: Abstract
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  Data: Sphingosine 1‐phosphate (S1P) is a bioactive lipid that binds to a family of G protein‐coupled receptors (S1P1–5) and intracellular targets, such as HDAC1/2, that are functional in normal and pathophysiologic cell biology. There is a significant role for sphingosine 1‐phosphate in cancer underpinning the so‐called hallmarks, such as transformation and replicative immortality. In this review, we survey the most recent developments concerning the role of sphingosine 1‐phosphate receptors, sphingosine kinase and S1P lyase in cancer and the prognostic indications of these receptors and enzymes in terms of disease‐specific survival and recurrence. We also provide evidence for identification of new therapeutic approaches targeting sphingosine 1‐phosphate to prevent neovascularisation, to revert aggressive and drug‐resistant cancers to more amenable forms sensitive to chemotherapy, and to induce cytotoxicity in cancer cells. Finally, we briefly describe current advances in the development of isoform‐specific inhibitors of sphingosine kinases for potential use in the treatment of various cancers, where these enzymes have a predominant role. This review will therefore highlight sphingosine 1‐phosphate signalling as a promising translational target for precision medicine in stratified cancer patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/1873-3468.13933
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        Text: English
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      – SubjectFull: Sphingosine kinase
        Type: general
      – SubjectFull: G protein coupled receptors
        Type: general
      – SubjectFull: Sphingosine
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      – TitleFull: Recent advances in the role of sphingosine 1‐phosphate in cancer.
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              Text: Nov2020
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              Y: 2020
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              Value: 594
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