Elastic Modulus of Woven Bone: Correlation with Evolution of Porosity and X-ray Greyscale.
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| Title: | Elastic Modulus of Woven Bone: Correlation with Evolution of Porosity and X-ray Greyscale. |
|---|---|
| Authors: | Mora-Macías, J.1 (AUTHOR) juan.mora@dimme.uhu.es, García-Florencio, P.2 (AUTHOR), Pajares, A.3 (AUTHOR), Miranda, P.3 (AUTHOR), Domínguez, J.2 (AUTHOR), Reina-Romo, E.2 (AUTHOR) |
| Source: | Annals of Biomedical Engineering. 2021, Vol. 49 Issue 1, p180-190. 11p. |
| Subjects: | Bone mechanics, Porosity, Compact bone, Young's modulus, Elastic modulus, Bones, X-rays, Stiffness (Mechanics) |
| Abstract: | The woven bone created during the healing of bone regeneration processes is characterized as being extremely inhomogeneous and having a variable stiffness that increases with time. Therefore, it is important to study how the mechanical properties of woven bone are dependent on its microarchitecture and especially on its porosity and mineral content. The porosity and the x-ray greyscale of specimens taken from bone transport studies in sheep were assessed by means of ex vivo imaging. Our study demonstrates that the porosity of the woven bone in the distraction area diminishes during the healing process from 73.3% 35 days after surgery to 31.9% 525 days after surgery. In addition, the woven bone's porosity is negatively correlated with its Young's modulus. The x-ray greyscale, was measured as an indicator of the level of mineralization of the woven bone. Greyscale index has been demonstrated to be inversely proportional to porosity and to increase to up to 60–80% of the level in cortical bone. The results of this study may contribute to the development of micromechanical models of woven bone and improvements in in silico modelling. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 147838475 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Elastic Modulus of Woven Bone: Correlation with Evolution of Porosity and X-ray Greyscale. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mora-Macías%2C+J%2E%22">Mora-Macías, J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> juan.mora@dimme.uhu.es</i><br /><searchLink fieldCode="AR" term="%22García-Florencio%2C+P%2E%22">García-Florencio, P.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pajares%2C+A%2E%22">Pajares, A.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miranda%2C+P%2E%22">Miranda, P.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Domínguez%2C+J%2E%22">Domínguez, J.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reina-Romo%2C+E%2E%22">Reina-Romo, E.</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. 2021, Vol. 49 Issue 1, p180-190. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Bone+mechanics%22">Bone mechanics</searchLink><br /><searchLink fieldCode="DE" term="%22Porosity%22">Porosity</searchLink><br /><searchLink fieldCode="DE" term="%22Compact+bone%22">Compact bone</searchLink><br /><searchLink fieldCode="DE" term="%22Young's+modulus%22">Young's modulus</searchLink><br /><searchLink fieldCode="DE" term="%22Elastic+modulus%22">Elastic modulus</searchLink><br /><searchLink fieldCode="DE" term="%22Bones%22">Bones</searchLink><br /><searchLink fieldCode="DE" term="%22X-rays%22">X-rays</searchLink><br /><searchLink fieldCode="DE" term="%22Stiffness+%28Mechanics%29%22">Stiffness (Mechanics)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The woven bone created during the healing of bone regeneration processes is characterized as being extremely inhomogeneous and having a variable stiffness that increases with time. Therefore, it is important to study how the mechanical properties of woven bone are dependent on its microarchitecture and especially on its porosity and mineral content. The porosity and the x-ray greyscale of specimens taken from bone transport studies in sheep were assessed by means of ex vivo imaging. Our study demonstrates that the porosity of the woven bone in the distraction area diminishes during the healing process from 73.3% 35 days after surgery to 31.9% 525 days after surgery. In addition, the woven bone's porosity is negatively correlated with its Young's modulus. The x-ray greyscale, was measured as an indicator of the level of mineralization of the woven bone. Greyscale index has been demonstrated to be inversely proportional to porosity and to increase to up to 60–80% of the level in cortical bone. The results of this study may contribute to the development of micromechanical models of woven bone and improvements in in silico modelling. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-020-02529-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 180 Subjects: – SubjectFull: Bone mechanics Type: general – SubjectFull: Porosity Type: general – SubjectFull: Compact bone Type: general – SubjectFull: Young's modulus Type: general – SubjectFull: Elastic modulus Type: general – SubjectFull: Bones Type: general – SubjectFull: X-rays Type: general – SubjectFull: Stiffness (Mechanics) Type: general Titles: – TitleFull: Elastic Modulus of Woven Bone: Correlation with Evolution of Porosity and X-ray Greyscale. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mora-Macías, J. – PersonEntity: Name: NameFull: García-Florencio, P. – PersonEntity: Name: NameFull: Pajares, A. – PersonEntity: Name: NameFull: Miranda, P. – PersonEntity: Name: NameFull: Domínguez, J. – PersonEntity: Name: NameFull: Reina-Romo, E. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 49 – Type: issue Value: 1 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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